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361. Recommendation: Hypertension in Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/hypertension-in-adults-screening
     April 27, 2021 - blood pressure monitoring offers the most evidence-based risk information for future cardiovascular events … suggested that screening is not associated with any substantial short-term quality of life changes or adverse … Seven studies (n = 3505) reported minor adverse events such as sleep disturbance, pain/discomfort, bruising … White-coat hypertension and cardiovascular events: a meta-analysis. … Cardiovascular events and mortality in white coat hypertension: a systematic review and meta-analysis

362. Interventions for High Body Mass Index in Children and Adolescents: US Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/kXAtzuxCxKJcHK9Fg63GA3
     April 01, 2023 - None of the trials found an increased risk of any ad- verse event or serious adverse events, including … More than 60% of youth taking liraglutide, semaglu- tide, or orlistat experienced gastrointestinal adverse … For example, in the largest trial of liraglutide, gastro- intestinal adverse effects occurred in 65% … effects).1,10 Serious adverse ef- fects were rare in all of the pharmacotherapy trials. … No evidence was available on adverse effects beyond 1 month after medication dis- continuation or longer

363. Recommendation: Prediabetes and Type 2 Diabetes: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-for-prediabetes-and-type-2-diabetes
     August 24, 2021 - Neither trial found statistically significant differences in cardiovascular events, quality of life, … , 23 Overall, trials found no statistically significant differences in all-cause mortality or CVD events … Three trials found higher rates of gastrointestinal adverse events associated with metformin. … Although not reported in studies, lactic acidosis is a rare but potentially serious adverse effect of … lifestyle interventions, especially among populations at highest risk for progression to diabetes and adverse

364. Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/ph_fauqHQjmrSqPAWKrARA
     September 28, 2021 - MAIN OUTCOMES AND MEASURES Diagnosis of preeclampsia; adverse pregnancy health outcomes and complications … Does effectiveness of aspirin for reducing adverse health outcomes vary by subpopulations defined by … Does aspirin reduce adverse maternal, perinatal, child, or combined health outcomes in pregnant persons … Excluded 3 studies with 0 events in both groups. … Associations between migraine and adverse pregnancy outcomes: systematic review and meta-analysis.

365. Evidence Summary: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
     August 20, 2019 - What are adverse effects of pretest genetic counseling? … What are adverse effects of genetic testing? … What are adverse effects of posttest genetic counseling? … compared with placebo, 150 and numbers of events were higher for tamoxifen than for raloxifene in the … , and all medications cause symptomatic adverse effects.

366. Archived: Final Evidence Summary: Low-Dose Aspirin Use for the Prevention of Morbidity and Mortality From Preeclampsia: Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary51/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication-september-2014
     April 08, 2014 - First, is low-dose aspirin effective for reducing adverse maternal and perinatal health outcomes among … All but 1 trial (44) reported more events in the placebo group. … Seven trials reported adverse events during the trial 40 , 41 , 46 , 47 , 49 , 50 , 53 . … In most cases, single adverse events were concluded to be unrelated to treatment. … general, the figure illustrates how the use of aspirin prophylaxis to prevent preeclampsia and related adverse

367. Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/6cRgd5whkAvSGESSQsrQLR
     January 01, 2020 - Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk … Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk … testing, procedures, and lifelong medication use without proof of benefit but with expense and potential adverse … Psychological harms may result from reclassification into a higher-risk category for CVD events. … Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

368. Draft Recommendation: Syphilis Infection During Pregnancy: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/syphilis-infection-pregnant-persons
     November 19, 2024 - improve health outcomes of pregnant persons. 1 Evidence from previous reviews 25 demonstrates fewer adverse … During the same time, the incidence of adverse pregnancy outcomes decreased from 42.7% to 19.2%, and … https://www.fda.gov/news-events/press-announcements/fda-marketing-authorization-enables-increased-access-first-step-syphilis-diagnosis … Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic … for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse

369. Archived: Evidence Summary: Iron Deficiency Anemia in Pregnant Women: Screening and Supplementation | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary22/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation-september-2015
     March 30, 2015 - routine iron supplementation in pregnant women were sparsely and variably reported, often as ad hoc events … effects, fatigue, or any adverse event. … Reversible GI symptoms associated with iron use 10 RCTs Outcomes reported mostly as ad hoc events … Maternal Adverse Events … Control Gestational Diabetes Pregnancy-Induced Hypertension GI Events Other Barton

370. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/MzHhsgTBL37rRvvJfkfgMZ
     August 20, 2019 - What are adverse effects of pretest genetic counseling? … What are adverse effects of genetic testing? … What are adverse effects of posttest genetic counseling? … compared with placebo (eTable 6 in the Supplement),150 and numbers of events were higher for tamoxifen … , and all medi- cations cause symptomatic adverse effects.

371. W-9Tarc9Nkw6Pe4Sfddmkz (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/W-9TArc9nkw6Pe4sfddMKZ
     July 01, 2013 - The more immedi- ate risk for adverse outcomes of GDM in the mother and child is less well-established … The number of events for many of the individual outcomes was extremely small, which did not provide adequate … Evidence was insufficient for birth injury due to imprecision (low number of events and participants … This is probably due to the infrequent occurrence of these events and a resulting lack of power across … Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991-2002. [PMID: 18463375] 3.

372. Primary Care Interventions to Prevent Child Maltreatment: Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/XGHwLrLfb_78ymEUwGF6jR
     March 19, 2024 - events included miscarriage/terminations, late mis- carriage, suspected miscarriage/termination, and … event (defined as primar- ily clinical events associated with pregnancy and infancy period) vs usual … care (43% vs 38%; calculated RR, 1.15 [95% CI, 1.03-1.25]).33 However, no adverse events were judged … The numbers of specific adverse events (miscarriages/ terminations, stillbirth/neonatal death/infant … Two studies did not report statistically significant adverse events between study groups.

373. Primary Care–Relevant Interventions to Prevent Falling in Older Adults: A Systematic Evidence Review for the U.S. Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/VpT-c4bnmvHFRPyKgPwb2Z
     December 01, 2010 - Three of these trials reported other adverse effects. … 819 cant abnormal laboratory or other diagnostic testing, hos- pitalization, or life-threatening events … events. … None of these trials reported additional adverse events. … most trials, reports of hypercalcemia and hypercalciuria were not associated with clinically relevant events

374. Evidence Summary: Prevention of Dental Caries in Children Younger Than 5 Years: Screening and Interventions | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/prevention-of-dental-caries-in-children-younger-than-age-5-years-screening-and-interventions1
     December 07, 2021 - evidence on harms associated with topical fluoride indicated no increased risk of fluorosis 48 or adverse … events 44 , 45 vs placebo. … Serious adverse events were not reported, though some children had difficulty tolerating the varnish … events (1 trial); reports of disagreeable odor Consistency cannot be determined (single trials reported … different adverse events), precise Harms not reported or suboptimal reporting in most trials Low-moderate

375. Archived: Evidence Summary: Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors: Behavioral Counseling | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary2/healthy-diet-and-physical-activity-counseling-adults-with-high-risk-of-cvd-august-2014
     August 26, 2014 - We also included observational studies that reported serious harms (that is, adverse events resulting … However, sparse reporting of both CVD events and self-reported measures of depression symptoms or QOL … Recent lifestyle intervention trials have not been shown to decrease CVD events. … Overall, a limited number of trials reported on adverse effects of interventions, and only 1 trial in … older adults found 2 events of serious harms as a result of physical activity [55].

376. Evidence Summary: Cervical Cancer: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/cervical-cancer-screening
     August 21, 2018 - events associated with the screening tests or with diagnostic and treatment procedures resulting from … events associated with screening, diagnostic screening, or treatment of CIN Reasonably consistent … events associated with screening, diagnostic screening, or treatment of CIN Two studies reported … events associated with screening, diagnostic screening, or treatment of CIN by age No trials … events associated with screening, diagnostic screening, or treatment of CIN by age False-negative

377. Archived: Evidence Summary: Suicide Risk in Adolescents, Adults and Older Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary20/suicide-risk-in-adolescents-adults-and-older-adults-screening
     April 15, 2013 - A subset of these trials ( κ = 12) also reported on adverse events or a (statistically nonsignificant … None identified serious adverse effects of screening 29 , 34 , 35 . … Specific adverse effects were not reported. … The trial with the largest increase was small ( n = 31 with follow-up) and had few events but reported … The analytic framework also depicts the possible adverse events occuring after screening or treatment

378. Screening for Prediabetes and Type 2 Diabetes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/h8qcZeQ68AQPS9DemArgXX
     July 13, 2021 - Most trials reporting mortality or CVD events over a follow-up duration of 6 years or less had few events … Categories and definitions used for adverse events were heterogenous across studies, and few trials … (3 trials) reported adverse events beyond 5 years of follow-up.65,66,74 Five trials reported rates … events; types of events re- ported (and definitions) were heterogeneous and most found no difference … Four studies of lifestyle interventions reported on musculoskeletal-related adverse events, 2 found

379. Recommendation: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/cardiovascular-disease-screening-using-nontraditional-risk-assessment
     July 10, 2018 - traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events … Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk … testing, procedures, and lifelong medication use without proof of benefit but with expense and potential adverse … Psychological harms may result from reclassification into a higher-risk category for CVD events. … Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

380. Evidence Summary: Hypertension in Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hypertension-in-adults-screening
     April 27, 2021 - Main Outcomes and Measures: Mortality; cardiovascular events; quality of life; sensitivity, specificity … screening’s effect on absenteeism is mixed. 39 , 73 , 85 ABPM follow-up testing is associated with minor adverse … For white coat hypertension, poor OBPM accuracy could result in unnecessary treatment and exposure to adverse … White-coat hypertension and cardiovascular events: a meta-analysis. … substantial short term QOL changes Scant evidence on absenteeism is mixed ABPM is associated with minor adverse