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www.uspreventiveservicestaskforce.org/uspstf/recommendation/diabetes-mellitus-type-2-in-adults-screening-2008
June 15, 2008 - USPSTF reviewed the evidence on early treatment of type 2 diabetes mellitus in preventing long-term adverse … Potential Harms of Screening and Treatment: Observational studies report no serious long-term adverse … No studies reported adverse effects of receiving a diagnosis of IFG or IGT, and no studies examined the … agents. 15 Angiotensin-converting enzyme inhibitors and statins have reasonably low levels of serious adverse … The relationship between glucose and incident cardiovascular events.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-and-nicotine-use-prevention-in-children-and-adolescents-primary-care-interventions
April 28, 2020 - however, most quit attempts fail, and about 80% will go on to smoke into adulthood. 36 Immediate adverse … of NRT found a greater number of headaches, cough, abnormal dreams, muscle pain, and patch-related adverse … events with NRT. 38 Bupropion carries a boxed warning for increased risk of suicidality in children … events, including suicidality, seizures, interaction with alcohol, cardiovascular events, sleepwalking … withdrew because of adverse events with bupropion. 14 Some studies reported more headaches, cough,
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/2DGd8AvVMTJwP3ttrPcnLL
February 25, 2020 - NRT found a greater num-
ber of headaches, cough, abnormal dreams, muscle pain, and patch-
related adverse … events with NRT.38 Bupropion carries a boxed warn-
ing for increased risk of suicidality in children … events, including suicidality, seizures, inter-
action with alcohol, cardiovascular events, sleepwalking … on benefits be-
cause its follow-up was less than 6 months.50 No difference in se-
rious or severe adverse … withdrew because of adverse events with bupropion.14 Some stud-
ies reported more headaches, cough,
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/SaASReVeD_fpHZQbeBZD5s
October 01, 2016 - Although statins in
middle-aged and older adults appear to be relatively
safe and short-term adverse … events generally resolve
with discontinuation of therapy, long-term adverse ef-
fects of statins started … Long-term in-
traindividual cholesterol variability: natural course and adverse im-
pact on morbidity … psychosocial consequences such as anxiety, overdiagnosis,
and others as identified in the literature)
KQ 2: Adverse … function tests or creatine
phosphokinase levels, and others as identified in the literature)
KQ 6: Other adverse
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication-november-2016
November 13, 2016 - used low and moderate doses; under these conditions, statin use was not associated with serious adverse … Myalgia is a commonly reported adverse effect of statins, but placebo-controlled trial data do not support … prevention of CVD, statin therapy was not associated with an increased risk of withdrawal because of adverse … experiencing any serious adverse event. … elevated aminotransferase levels with statin use. 6
Evidence on the association between statin use and adverse
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/vitamin-supplementation-to-prevent-cancer-and-cvd-counseling-and-preventive-medication
June 15, 2003 - vitamin E supplementation for secondary prevention demonstrated a significant reduction in cardiac events … heavy smokers, in 2 RCTs. 14 , 25 Results from 4 RCTs demonstrate no reduced risk for cardiovascular events … Among cohort studies, 1 good-quality study reported a significant reduction in coronary events, 36 2 … The adverse effects of vitamin supplementation were not reported in most studies reviewed by the USPSTF … Vitamin E supplementation and cardiovascular events in high-risk patients.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/vitamin-supplementation-to-prevent-cancer-and-cvd-counseling-and-preventive-medication-2003
June 15, 2003 - vitamin E supplementation for secondary prevention demonstrated a significant reduction in cardiac events … heavy smokers, in 2 RCTs. 14 , 25 Results from 4 RCTs demonstrate no reduced risk for cardiovascular events … Among cohort studies, 1 good-quality study reported a significant reduction in coronary events, 36 2 … The adverse effects of vitamin supplementation were not reported in most studies reviewed by the USPSTF … Vitamin E supplementation and cardiovascular events in high-risk patients.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/cognitive-impairment-in-older-adults-screening
October 19, 2017 - due to labeling (psychological harms, insurance status, loss of driving privileges)
KQ 5: Serious adverse … events (e.g., death, serious adverse drug reactions), adverse reactions from medications, unexpected
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/impaired-visual-acuity-in-older-adults-screening-2016
March 01, 2016 - antioxidant vitamins and mineral supplements is not associated with increased risk of most serious adverse … events. … with greater likelihood of withdrawal vs sham therapy; there were no differences in serious or other adverse … events, but estimates were imprecise. 1 , 4 , 6 , 7
Current Practice
About half of US adults … event, serious adverse events, serious ocular events, or withdrawal due to adverse events. 1
Treatment
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/CW23r2jqogvTG2_-kBjRxH
January 01, 2007 - in children/adolescents effective in
delaying the onset and reducing the incidence of CHD-related events … of screening for dyslipidemia in identifying
children/adolescents at increased risk of CHD-related events … incidence of adult dyslipidemia,
and delaying the onset and reducing the incidence of CHD-related events … Drug treatment
Information about adverse events was reported in 15 studies of statins,18, 19, 165, … There are no trials with long-term follow-up for adult
23
lipid outcomes or CHD-related events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/8VDGX2azX2-s7FfxDeKMPN
June 01, 2003 - • The adverse effects of beta-carotene on smokers
have been observed primarily in those taking
large … vitamin E
supplementation for secondary prevention
demonstrated a significant reduction in cardiac
events … Among cohort studies,
1 good-quality study reported a significant reduction
in coronary events,36 2 good-quality … Potential Harms of Vitamin
Supplementation
There are several known adverse effects caused by
excessive … Vitamin E supplementation and cardiovascular events
in high-risk patients.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/menopausal-hormone-therapy-preventive-medication-december-2017
December 12, 2017 - individual characteristics that affect the likelihood of experiencing a specific therapy-associated adverse … to women at increased risk of breast cancer who do not have contraindications and are at low risk of adverse … findings from the Women’s Health Initiative (WHI) that hormone therapy use was associated with serious adverse … individual characteristics that affect the likelihood of experiencing a specific therapy-associated adverse … in women at increased risk of breast cancer who do not have contraindications and are at low risk of adverse
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/high-cholesterol-other-lipid-abnormalities-screening-1996
January 01, 1996 - due to effects of estrogen, 5 but women account for 49% of all CHD deaths in the U.S. 2 Clinical events … 3%. 20 High cholesterol (≥240 mg/dL) is also a risk factor in middle-aged women, but most coronary events … nonlipid risk factors, persons with cholesterol below 240 mg/dL account for the majority of all CHD events … New insights into prevention of plaque disruption and clinical events in coronary disease. … Review of dietary intervention studies: effect on coronary events and on total mortality.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/depression-in-adults-screening-2009
December 15, 2009 - Also, information on the possible adverse effects and harms of depression care management programs is … events from antidepressant treatment in all adults. … effects of treatment of patients who are incorrectly identified as being depressed, and potential adverse … Harms of treatment include serious adverse effects of antidepressants, such as suicide-related events … For older adults, harms of treatment also include serious medical events, such as UGI bleeding.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/KdQef_VDT2kmHDX4ddNWmR
August 01, 2022 - isoniazid (RR, 1.50 [95% CI, 1.18-1.89])
and a greater risk of gastrointestinal adverse events (RR, 1.33 … Recent trials also reported on discontinuation due to adverse
events. … There was a statistically nonsignificant increase in discontinu-
ation due to adverse events in a meta-analysis … this was statistically significant in only 1 trial.9,28 Overall, study re-
ports of gastrointestinal adverse … Adverse
events with 4 months of rifampin therapy or 9
months of isoniazid therapy for latent tuberculosis
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/72-qtLK_m7urbSFT2yQZ2A
June 01, 2023 - previously and using clinical
judgment while considering risk factors, comorbid conditions, and life events … depression, prior episodes of depression or other
mental health conditions, a history of trauma or adverse … life events, or a history of disease or illness
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/3w8Wr9wwAyAqUJWmJo_bL-
February 01, 2014 - Women us-
ing tamoxifen and raloxifene had more thromboembolic
events than women using placebo (tamoxifen … Coronary
heart disease events and stroke were not increased in
placebo-controlled trials, although women … Few studies described adverse effects. … In trials, tamoxifen and raloxifene increased thromboem-
bolic events and tamoxifen increased endometrial … Effects of
raloxifene on cardiovascular events and breast cancer in postmenopausal women.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/skin-cancer-screening-1
January 07, 2021 - beyond 30 days) from screening, biopsy, or excision; including psychosocial harms and procedure-related adverse … events
KQs 1, 2, 4:
Non-skin location
Risk reduction behaviors (e.g., skin self-examination
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/2VxcSta8ko2L_GC97XjZqm
September 01, 2015 - balance of benefits and harms of screening for
iron deficiency anemia in pregnant women to prevent adverse … assess the balance of benefits and harms of routine iron
supplementation for pregnant women to prevent adverse … adverse maternal health and
birth outcomes
Negative events, such as
premature birth, low birth weight
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/falls-prevention-in-older-adults-interventions
April 17, 2018 - Eight studies (n=4107) evaluating exercise interventions reported on harms; in general, adverse events … were minor. 8 , 10 The most common adverse events included pain or bruising related to exercise. … or severe adverse events, although ascertainment of adverse events was unclear. 8 One study on a single … psychological intervention reported no adverse events. 25 The remaining studies did not report on harms … or adverse events.