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  1. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/healthy-diet-and-physical-activity-counseling-for-cvd-prevention-in-adults
    December 15, 2010 - Key Question 4: Harms Adverse effects were rarely noted in physical activity counseling trials. … We found no studies designed to assess the adverse effects of dietary counseling or the adverse effects … None of the healthful diet counseling trials reported specific adverse events.   … However, the absolute risk for serious cardiac events related to physical activity seems very small. … events not reported in trials Good Good No specific examination of adverse effects
  2. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary13/healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-behavioral-counseling-2012
    December 07, 2010 - Key Question 4: Harms Adverse effects were rarely noted in physical activity counseling trials. … We found no studies designed to assess the adverse effects of dietary counseling or the adverse effects … None of the healthful diet counseling trials reported specific adverse events. … However, the absolute risk for serious cardiac events related to physical activity seems very small. … events not reported in trials Good Good No specific examination of adverse effects; however, 2
  3. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/healthy-diet-and-physical-activity-counseling-for-cvd-prevention-in-adults-2012
    December 15, 2010 - Key Question 4: Harms Adverse effects were rarely noted in physical activity counseling trials. … We found no studies designed to assess the adverse effects of dietary counseling or the adverse effects … None of the healthful diet counseling trials reported specific adverse events.   … However, the absolute risk for serious cardiac events related to physical activity seems very small. … events not reported in trials Good Good No specific examination of adverse effects
  4. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/impaired-visual-acuity-in-older-adults-screening
    March 01, 2016 - use vs placebo in risk of any adverse events (93% vs 89%; RR, 1.05; 95% CI, 0.97–1.13), serious adverseevents (31% vs 30%; RR, 1.04; 95% CI, 0.72–1.49), or serious ocular adverse events (8.2% vs 7.0%; RR … events, but estimates for those outcomes were imprecise. … events in participants taking zinc vs placebo. … No increase in risk of systemic hypertension or arterial thromboembolic events.
  5. www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/impaired-visual-acuity-in-older-adults-screening-2016
    March 01, 2016 - use vs placebo in risk of any adverse events (93% vs 89%; RR, 1.05; 95% CI, 0.97–1.13), serious adverseevents (31% vs 30%; RR, 1.04; 95% CI, 0.72–1.49), or serious ocular adverse events (8.2% vs 7.0%; RR … events, but estimates for those outcomes were imprecise. … events in participants taking zinc vs placebo. … No increase in risk of systemic hypertension or arterial thromboembolic events.
  6. www.uspreventiveservicestaskforce.org/home/getfilebytoken/RPB3rmcS9CK_eXPdzXSxZg
    July 01, 2010 - Bisphosphonates are not con­ sistently associated with serious adverse events; raloxifene and es­ trogen … increase thromboembolic events; and estrogen causes addi­ tional adverse events. … no differences with placebo in rates of serious gastrointestinal adverse events (107, 108) or withdrawals … Upper gastrointestinal adverse events and cyclical etidronate. Am J Med. 1997;103:462-7. … Adverse Health Outcomes from Studies, by Medication Adverse Outcome Evidence Bisphosphonates Withdrawals
  7. www.uspreventiveservicestaskforce.org/home/getfilebytoken/poDYcagnw7SqKNNbrFt_CV
    June 11, 2019 - Limited data suggest that PrEP use is not associated with significant adverse events in adolescents but … There was no clear difference in risk of kidney adverse events when trials were stratified according … of serious renal events or with- drawals due to renal events.31,32 Six trials41,42,55-58 evaluated whether … renal adverse events while using PrEP were persistent. … The risk of gastrointes- tinal adverse events increased with both tenofovir disoproxil fuma- rate monotherapy
  8. www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-and-nicotine-use-prevention-in-children-and-adolescents-primary-care-interventions
    April 28, 2020 - however, most quit attempts fail, and about 80% will go on to smoke into adulthood. 36 Immediate adverse … of NRT found a greater number of headaches, cough, abnormal dreams, muscle pain, and patch-related adverseevents with NRT. 38 Bupropion carries a boxed warning for increased risk of suicidality in children … events, including suicidality, seizures, interaction with alcohol, cardiovascular events, sleepwalking … withdrew because of adverse events with bupropion. 14 Some studies reported more headaches, cough,
  9. JAMA (pdf file)

    www.uspreventiveservicestaskforce.org/home/getfilebytoken/2DGd8AvVMTJwP3ttrPcnLL
    February 25, 2020 - NRT found a greater num- ber of headaches, cough, abnormal dreams, muscle pain, and patch- related adverseevents with NRT.38 Bupropion carries a boxed warn- ing for increased risk of suicidality in children … events, including suicidality, seizures, inter- action with alcohol, cardiovascular events, sleepwalking … on benefits be- cause its follow-up was less than 6 months.50 No difference in se- rious or severe adverse … withdrew because of adverse events with bupropion.14 Some stud- ies reported more headaches, cough,
  10. www.uspreventiveservicestaskforce.org/home/getfilebytoken/VKGPkVjto7K4yfUHBKEHBA
    January 01, 2025 - of findings from the Women’s Health Initiative that hormone therapy use is associated with serious adverse … findings from the Women’s Health Initiative (WHI) that hormone therapy use was associated with serious adverse … individual char- acteristics that affect the likelihood of experiencing a specific therapy- associated adverse … in women at increased risk of breast cancer who do not have contraindications and are at low risk of adverse … individual characteristics that affect the likelihood of experiencing a specific therapy-associated adverse
  11. www.uspreventiveservicestaskforce.org/uspstf/recommendation/peripheral-arterial-disease-pad-screening
    August 08, 2005 - group; however, the study did not address the impact of interventions on PAD or cardiovascular disease events … intermittent claudication. 14 Potential harms of screening include false-positive results, labeling, and the adverseevents associated with an angiographic workup, including contrast-related events, arterial perforations … , hematomas, thromboses, and distal embolizations; the harms of treatment include the adverse events
  12. www.uspreventiveservicestaskforce.org/uspstf/recommendation/peripheral-arterial-disease-pad-screening-2005
    August 08, 2005 - group; however, the study did not address the impact of interventions on PAD or cardiovascular disease events … intermittent claudication. 14 Potential harms of screening include false-positive results, labeling, and the adverseevents associated with an angiographic workup, including contrast-related events, arterial perforations … , hematomas, thromboses, and distal embolizations; the harms of treatment include the adverse events
  13. www.uspreventiveservicestaskforce.org/home/getfilebytoken/hbSopN6uA9u-4EQuKtRGDP
    October 01, 2011 - events Context Experts recommend that primary care clinicians offer obese adults interventions that … events (Table 2) (22, 83, 102). … No studies re- ported serious adverse effects. … Summary of Medication Harms Adverse Events Trials in Meta-analysis, Additional Trials, n, n Meta-analysis … Meridia (sibutramine): market with- drawal due to risk for serious cardiovascular events.
  14. www.uspreventiveservicestaskforce.org/uspstf/recommendation/diabetes-mellitus-type-2-in-adults-screening
    June 15, 2008 - USPSTF reviewed the evidence on early treatment of type 2 diabetes mellitus in preventing long-term adverse … Potential Harms of Screening and Treatment: Observational studies report no serious long-term adverse … No studies reported adverse effects of receiving a diagnosis of IFG or IGT, and no studies examined the … agents. 15 Angiotensin-converting enzyme inhibitors and statins have reasonably low levels of serious adverse … The relationship between glucose and incident cardiovascular events.
  15. www.uspreventiveservicestaskforce.org/uspstf/recommendation/diabetes-mellitus-type-2-in-adults-screening-2008
    June 15, 2008 - USPSTF reviewed the evidence on early treatment of type 2 diabetes mellitus in preventing long-term adverse … Potential Harms of Screening and Treatment: Observational studies report no serious long-term adverse … No studies reported adverse effects of receiving a diagnosis of IFG or IGT, and no studies examined the … agents. 15 Angiotensin-converting enzyme inhibitors and statins have reasonably low levels of serious adverse … The relationship between glucose and incident cardiovascular events.
  16. www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary39/obesity-in-children-and-adolescents-screening-2010
    January 15, 2010 - , any serious adverse event, or discontinuation caused by adverse events. … In the large 12-month sibutramine trial, serious adverse events were reported by 2.7% of patients in … Weight-management programs for which pre-specified adverse events that resulted in death, hospitalization … No minimum follow-up is required for serious (ie, requiring urgent medical care) adverse events (KQ3) … For trials that were not included for KQ1 or KQ2, outcomes were limited to serious adverse events such
  17. www.uspreventiveservicestaskforce.org/home/getfilebytoken/VwvmgA5bLZZJhK6YSqRonU
    November 01, 2022 - Adverse health outcomes associated with untreated OSA include cardiovascular disease and cerebrovascular … events, type 2 diabetes, cognitive impairment, decreased quality of life, and motor vehicle crashes
  18. www.uspreventiveservicestaskforce.org/uspstf/recommendation/vitamin-d-deficiency-screening
    April 13, 2021 - The goal of screening for vitamin D deficiency would be to identify and treat it before associated adverse … The USPSTF found 36 studies that reported adverse events and harms from treatment with vitamin D (with … The absolute incidence of adverse events varied widely across studies; however, the incidence of total … adverse events, such as gastrointestinal symptoms, fatigue, musculoskeletal symptoms, and headaches, … and serious adverse events was generally similar between treatment and control groups.
  19. www.uspreventiveservicestaskforce.org/home/getfilebytoken/4BpSYQnx9MYzmKJSWQxrbC
    April 13, 2021 - The goal of screening for vitamin D deficiency would be to identify and treat it before associated adverse … The USPSTF found 36 studies that reported adverse events and harms from treatment with vita- min D (with … The absolute incidence of adverse events varied widely across studies; however, the incidence of total … adverse events, such as gastrointestinal symptoms, fatigue, musculoskeletal symptoms, and headaches, … and serious adverse events was generally similar between treatment and control groups.
  20. www.uspreventiveservicestaskforce.org/home/getfilebytoken/KdQef_VDT2kmHDX4ddNWmR
    August 01, 2022 - isoniazid (RR, 1.50 [95% CI, 1.18-1.89]) and a greater risk of gastrointestinal adverse events (RR, 1.33 … Recent trials also reported on discontinuation due to adverse events. … There was a statistically nonsignificant increase in discontinu- ation due to adverse events in a meta-analysis … this was statistically significant in only 1 trial.9,28 Overall, study re- ports of gastrointestinal adverseAdverse events with 4 months of rifampin therapy or 9 months of isoniazid therapy for latent tuberculosis

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