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301. Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/h5Tt4jScmQJeHeztmo93hu
     February 25, 2020 - - vational studies (n = 190 076) reported on the harms of treatment with AChEIs and memantine.16,17 Adverse … Adverse events were significantly higher in patients receiving AChEIs, and more patients receiving AChEIs … Memantine was better tolerated, with no increase in adverse events or withdrawal rates compared with … Overall, there was no increase in serious adverse events in patients taking AChEIs. … However, some individual studies reported increased rates of serious adverse events, such as brady- cardia

302. Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/2GDCmTe7akyrAHsTMbfz72
     May 06, 2022 - prevention clinical land- scape because of their well-established CVD and mortality ben- efits and favorable adverse … Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular … events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE … Adverse effects of low-dose aspirin in a healthy elderly population. … Association of aspirin use for primary prevention with cardiovascular events and bleeding events: a systematic

303. Using Nontraditional Risk Factors in Coronary Heart Disease Risk Assessment: U.S. Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/gXnmnkofo8FxoLnCmXJDjb
     October 01, 2009 - Potential adverse effects of using these risk factors include false-positive test results and labeling … such as coro- nary angiography), and side effects of aggressive risk factor management (such as the adverse … Prediction of coronary events with electron beam computed tomography. … Homocysteine lowering and cardiovascular events after acute myocardial infarction. … Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

304. Aspirin for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: A Decision Analysis for the USPSTF (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
     April 01, 2016 - If adverse bleeding event, discontinue aspirin Screen and treat for hypertension and lipid disorders … If CVD event, initiate secondary CVD prevention, including aspirin, if eligible If adverse bleeding … . �� Defined by the net of benefit and harm events or this equation: (nonfatal CVD events + CVD deaths … Rationale for a trial of low-dose aspirin for the primary prevention of major adverse cardiovascular … events and vascular dementia in the elderly: Aspirin in Reducing Events in the Elderly (ASPREE).

305. Screening for Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/6hyj7-3s6Qxs-brqhxPVxD
     June 06, 2017 - FIT, resulting in more false-positive results, more diagnostic colonoscopies, and more associated adverse … The rate of serious adverse events from colorectal cancer screening increases with age.1 Thus, the … colorectal cancer compared with FIT alone.13 The harms of stool-based testing primarily result from adverse … If sedation is usedduring colonoscopy, cardiopul­ monary adverse events may rarely occur; the precise … appear tobe related topolypectomy, and the risk of experiencing an adverse event increases with age

306. 4Nuuvs6Nmztdbgjbg3Elke (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/4NUuvS6nmzTdBgjBg3ELkE
     January 01, 2020 - We also included observational studies that reported serious harms (that is, adverse events resulting … Adverse effects Trials: 10 Participants: 6381 Fair: sparse reporting of harms Consistent findings … medical attention), except in 1 trial (302 participants) targeting older adults (2 persons with a serious adverse … Recent studies of lifestyle interventions have not found decreased CVD events. … Overall, a limited number of tri- als reported on adverse effects of interventions, and only 1 trial

307. Archived: Final Evidence Summary: Intimate Partner Violence and Abuse of Elderly and Vulnerable Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary32/intimate-partner-violence-and-abuse-of-elderly-and-vulnerable-adults-screening-2013
     May 08, 2012 - To evaluate adverse effects, we included several study designs that reported adverse effects of screening … both groups reported fewer threats of abuse ( P < 0.001), assaults, danger risks for homicide, and events … What are the adverse effects of screening for IPV? … Appendix Figure 1 is an analytic framework for the key questions of this report that depicts the events … The figure also depicts the possibility of harms or adverse events occurring as a result of screening

308. Evidence Summary: Pregnant Women: Human Immunodeficiency Virus (HIV) Infection: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-pregnant-women1/human-immunodeficiency-virus-hiv-infection-screening
     June 11, 2019 - events than zidovudine alone (21% vs 17%, P = 0.008). … events. … Antiretroviral therapy during pregnancy and the risk of an adverse outcome. … b Include adverse maternal and infant outcomes associated with use of antiretroviral therapy. … event vs zidovudine monotherapy, but few women left the study because of adverse events Consistent

309. Archived: Final Research Plan: Drug Use, Illicit: Primary Care Interventions for Children and Adolescents | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan18/drug-use-illicit-primary-care-interventions-for-children-and-adolescents-march-2014
     May 15, 2013 - What are the adverse effects of primary care–relevant behavioral counseling drug use interventions? … biochemical verification) No use Frequency of use Quantity of use KQ 3: (adverse … events) Serious treatment-related harms at any time point after the intervention began (e.g

310. Final Research Plan: Prevention of Acquisition of HIV: Preexposure Prophylaxis | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis
     January 13, 2022 -     *Harms also include renal dysfunction, adverse … with antiretroviral drug-resistant HIV, gastrointestinal harms, headaches, and discontinuation due to adverse

311. Archived: Colorectal Cancer: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/colorectal-cancer-screening-june-2016
     June 15, 2016 - The rate of serious adverse events from colorectal cancer screening increases with age. 1 Thus, the … colorectal cancer compared with FIT alone. 13 The harms of stool-based testing primarily result from adverse … false-positive results and higher likelihood of follow-up colonoscopy and experiencing an associated adverse … appear to be related to polypectomy, and the risk of experiencing an adverse event increases with age … for FIT, resulting in more false-positive results, more diagnostic colonoscopies, and more associated adverse

312. Final Evidence Summary: Cognitive Impairment in Older Adults: Screening | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/cognitive-impairment-in-older-adults-screening
     February 25, 2020 - Studies were required to report total adverse events, withdrawals attributable to adverse events, or … serious adverse events that resulted in unexpected medical care, morbidity, or mortality. … Adverse events were reported in all 48 RCTs 77 , 81 , 83 , 85 , 93 , 96 , 100 , 110 , 116 , 124 , 127 … Total adverse events were also statistically significantly higher for all 3 types of AChEI vs placebo … Overall, there did not appear to be differences in total serious adverse events for these medications

313. Archived: Evidence Summary: Aspirin for the Prevention of Cardiovascular Disease: Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary10/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication-2009
     March 15, 2009 - bleeding events, in both men and women. … Aspirin use increases the risk for serious bleeding events. … The meta-analysis of RCTs discussed for the key question on benefits 8  reported adverse events with … bleeding events, in both men and women. … without an increased risk for major bleeding events.

314. Procedure Manual Section 6. Methods for Arriving at a Recommendation | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-6-methods-arriving-recommendation
     July 06, 2017 - clinically meaningful improvements in health-related quality of life, or avoidance of specific disease events … (e.g., cardiovascular events, cancer incidence and mortality, visual impairment, complications from … Similarly, if overdiagnosis (and therefore overtreatment) is common, and if the treatment has some adverse … Benefits are often quantified in terms of lives extended, quality of life improved, or illness events … the false-positive screening test rate, overdiagnosis, diagnostic tests and their complications, or adverse

315. Individualizing Cancer Screening in Older Adults | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/individualizing-cancer-screening-older-adults
     March 01, 2021 - relevant to older adults include those related to preparing for the test (for example, discomfort or adverse … colon perforation, fatigue from a long testing day), and harms of procedure after-care (for example, adverse … A review of adverse events associated with colonoscopy found that most studies were retrospective reviews … However, many had experienced adverse medication events and could use this experience to understand competing

316. Screening and Interventions for Overweight in Children and Adolescents: Recommendation Statement (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/J-vUTejXWsdp_d86zK4Gth
     July 01, 2005 - for or against routine screening for overweight in children and adolescents as a means to prevent adverse … is associated with a higher prevalence of intermediate metabolic consequences and risk factors for adverse … events.34 No acceptable quality evidence is available for children or adolescents to be able to evaluate … Among 4 recent behavioral intervention trials, 4 adverse effects were reported in 1 trial.33 Among … No other adverse events were reported.34 The direct health costs of childhood overweight can only

317. Archived: Obesity in Children and Adolescents: Screening, July 2005 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/recommendation/obesity-in-children-and-adolescents-screening-2005
     July 11, 2005 - recommend for or against routine screening for overweight in children and adolescents as a means to prevent adverse … is associated with a higher prevalence of intermediate metabolic consequences and risk factors for adverse … events.34 No acceptable quality evidence is available for children or adolescents to be able to evaluate … Among 4 recent behavioral intervention trials, adverse effects were reported in 1 trial. 33 Among those … No other adverse events were reported. 34 The direct health costs of childhood overweight can only

318. Screening for Cognitive Impairment in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
     www.uspreventiveservicestaskforce.org/home/getfilebytoken/njteJ388DLVsY8RLcBTe_A
     February 25, 2020 - Studies were required to report total adverse events, withdrawals attributable to adverse events, or … serious adverse events that re- sulted in unexpected medical care, morbidity, or mortality. … Total adverse events were also statistically significantly higher for all 3 types of AChEI vs placebo … events compared with placebo. … Overall, there did not appear to be differences in total serious adverse events for these medications

319. Archived: Final Research Plan: Healthy Diet: Behavioral Counseling in Primary Care, January 2003 | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan29/diet-behavioral-counseling-primary-care-adults-2003
     February 03, 2014 - What are the adverse effects of primary care–relevant behavioral counseling interventions for healthy … outcomes (physical activity, dietary intake or patterns), self-reported or objectively measured KQ 4: Adverse … requiring medical attention (e.g., nutritional deficiencies, musculoskeletal injuries, cardiovascular events

320. Archived: Final Evidence Summary: Falls Prevention in Older Adults: Counseling and Preventive Medication | United States Preventive Services Taskforce
     www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary24/falls-prevention-in-older-adults-counseling-and-preventive-medication-2012
     December 15, 2010 - Three of these trials reported other adverse effects. … events. … None of these trials reported additional adverse events. … most trials, reports of hypercalcemia and hypercalciuria were not associated with clinically relevant events … Appendix Figure 1 is an analytic framework that depicts the events that older adults experience while