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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Vc8SLesU493dFQmMKadxGL
December 01, 2003 - Increased BMI is associated
with an increase in adverse health effects. … The adverse effects of
orlistat include fecal urgency, oily spotting, and
flatulence; the adverse effects … There are no data on the long-term (longer
than 2 years) benefits or adverse effects of these
drugs. … Common adverse effects occur more
frequently with sibutramine (especially an increase
in blood pressure … and heart rate), but no serious
adverse events were reported.31 Orlistat causes
gastrointestinal fecal
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/preeclampsia-screening-april-2017
April 25, 2017 - risk include a history of eclampsia or preeclampsia (particularly early-onset preeclampsia), previous adverse … Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth … include a history of eclampsia or preeclampsia (particularly early-onset preeclampsia), a previous adverse … events. … studies of timing of delivery, trial evidence supports delivery of the fetus to reduce the risk of adverse
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4_pXjq7Egjwb_vjZZT-NGB
May 01, 2021 - prevented, yet American Indian/Alaska
Native persons and Black persons experience inequitable rates of adverse … events (includ-
ing missed diagnosis). … infant health outcomes; none were statistically significant
between study groups, but most were rare events … trials underpowered
to detect small differences in
rare, serious outcomes; 1 small
trial had too few events … Racial
disparities in adverse pregnancy outcomes and
psychosocial stress.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/g2bEcQW6ae_NTFZ9KUxT_t
August 24, 2021 - Neither trial
found statistically significant differences in cardiovascular events,
quality of life … in the intervention group receiving insulin who died from hy-
poglycemia, and serious hypoglycemic events … Three trials found
higher rates of gastrointestinal adverse events associated with met-
formin. … Although not reported in studies, lactic acidosis is a rare but
potentially serious adverse effect of … style interventions, especially among populations at highest risk
for progression to diabetes and adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-review48/hepatitis-b-in-pregnant-women-screening-2009
June 15, 2009 - because the benefits of prophylaxis for newborns of HBsAg-positive mothers greatly outweigh the potential adverse … which may lead to psychological harms, increased costs, and inconvenience of subsequent testing, and adverse … We found no new studies that described false-positive screening rates or downstream events associated
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/MjwZ4vRLZDVUSnfMA6SrDo
June 01, 2012 - To evaluate adverse effects, we included
several study designs that reported adverse effects of screen … Adverse effects of
screening were actively monitored. … , both groups reported fewer threats of abuse (P � 0.001),
assaults, danger risks for homicide, and events … of Screening Tool) showed no adverse
effects with screening. … What are the adverse effects of screening for IPV?
4.
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/unhealthy-alcohol-use-adolescents-adults-behavioral-counseling-interventions
August 05, 2025 - Alcohol consumption during pregnancy can result in fetal alcohol spectrum disorders and additional adverse … reviewed epidemiologic evidence on the association between excessive alcohol consumption and a range of adverse … reviewed 7 studies (n= 3991) on the harms of interventions to reduce UAU in adults and none reported any adverse … events in the intervention or control groups. 1
Return to Table of Contents
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary19/high-blood-pressure-in-adults-screening-monitoring-october-2015
December 22, 2014 - For prediction of cardiovascular events, we combined fatal and nonfatal events within outcome categories … Results were inconsistently significant for cardiac events, CHF, and all-cause mortality. … persons had a consistently higher incidence of hypertension at rescreening than white persons.
5 (adverse … Which methods and associated protocols best predict cardiovascular events?
b. … What are the adverse effects of screening for high blood pressure in adults?
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/n4sdjxShTApRE6UxvyYuzG
November 01, 2008 - Serious
complications—defined as deaths attributable to colonos-
copy or adverse events requiring hospital … Fecal Occult Blood Tests
No current studies adequately address any adverse ef-
fects of high-sensitivity … Serious complications—deaths from colonoscopies in
asymptomatic populations or events requiring hospital … benefit, where the number of colonos-
copies represents a proxy for resource utilization as well as
adverse … events from screening.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/dvDjnZzW9PDxzKBauB4QxA
August 21, 2018 - events
associated with screening, diagnostic
screening, or treatment of CIN
Reasonably consistent … events
associated with screening, diagnostic
screening, or treatment of CIN
Two studies reported that … events associated
with screening, diagnostic screening,
or treatment of CIN by age
No trials with > … events associated
with screening, diagnostic screening,
or treatment of CIN by age
False-negative invasive … reporting on colposcopy and bi-
opsy rates was inconsistent, and none of the trials reported on ad-
verse events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/aSLgQ3VeNEmowQmpvPk_Xe
March 01, 2004 - current treatment regimen is long and
costly and is associated with a high patient dropout
rate due to adverse … Potential harms of
screening and treatment include labeling, adverse
treatment effects, and unnecessary … of patients receiving
interferon-based therapies alone or in conjunction
with ribavirin experience adverse … Patient
withdrawal due to adverse effects from interferon
monotherapy averaged 5%, and patient withdrawal … from combination therapy ranged from 10% to
20%.2 The most common adverse event was flu-like
syndrome
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/iron-deficiency-anemia-in-pregnant-women-screening-and-supplementation
August 20, 2024 - Harms of iron supplementation included transient gastrointestinal adverse effects. … Adverse effects included clinical harms, harms leading to discontinuation, and accidental overdose. … No trial reported any serious adverse events from iron supplementation, and infant harms were not reported … 1.28-1.97]). 32 In contrast, no statistically significant differences in rates of gastrointestinal adverse … consistent
Some imprecision
Some reporting bias detected
Outcomes mostly reported as ad hoc events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/827CwGYMVawpVoVg_syJpF
October 01, 2015 - balance of benefits and harms
of screening for iron deficiency anemia in pregnant women to
prevent adverse … balance of benefits and harms
of screening for iron deficiency anemia in pregnant
women to prevent adverse … Many observational studies have explored the as-
sociation between adverse maternal and infant health … Reported adverse events of iron sup-
plementation or treatment with iron include limited
gastrointestinal … The major concern about iron deficiency anemia in
pregnant women is whether it has adverse effects on
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/hhrqMCEgbsBMJ_Ppbcp4yJ
January 14, 2025 - A pooled analysis of 21 RCTs found no significant differ-
ence in serious adverse events. … One trial reported a statistically sig-
nificant increase in gastrointestinal adverse events in the treatment … events in participants tak-
ing bisphosphonates compared with those taking placebo. … ing from 0.01% to 0.06%.64
For denosumab, pooled analyses found no significant increase
in serious adverse … events (5 RCTs) or upper gastrointestinal tract ad-
verse events (4 trials), although the CIs were wide
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www.uspreventiveservicestaskforce.org/uspstf/document/screening-for-hiv-in-pregnant-women-evidence-summary/human-immunodeficiency-virus-hiv-infection-screening-2013
November 15, 2012 - What are the adverse effects (including false-positive tests and anxiety) of rapid versus standard HIV … pregnancy outcomes; adverse congenital, neurodevelopmental, cardiovascular, metabolic, or hematologic … No study compared psychological or other harms associated with rapid versus standard tests or adverse … USPSTF review included 1 study of 226 U.S. women that found no difference in risk for AIDS-defining events … Antiretroviral therapy during pregnancy is associated with the nonobstetric adverse events typically
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breastfeeding-primary-care-interventions
April 11, 2025 - health outcome (eg, maternal mental health symptoms, infant or child gastrointestinal symptoms), or adverse … Seven of the 90 included trials (n = 1404) commented on the occurrence of adverse events or lack of adverse … events; 41 , 42 , 56 , 75 , 77 , 82 , 94 5 of these studies reported that no adverse events were reported … precise
Unclear applicability, given proportion of trials reporting harms
Six trials reported “no adverse … events” related to the intervention
One trial reported greater feelings of anxiety, decreased confidence
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/6fFns4N2J-t5EGC5BUdRuu
October 23, 2023 - that PrEP is associated with a small magnitude of harms, which include
kidney and gastrointestinal adverse … with patients, patient education, reminder systems for
taking medication, and attention to medication adverse … events (primar-
ily grade 1 or higher creatinine level elevation) (12 trials [n = 18 170];
RR, 1.43 … tenofovir disoproxil fuma-
rate alone was associated with increased risk of gastrointestinal ad-
verse events … events (1% vs 1%) or risk
of fracture (2% vs 2%).38 Two trials (n = 7786) reported no differ-
ences
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/syphilis-infection-in-pregnancy-screening
May 13, 2025 - or improve maternal health outcomes. 1 , 30 Evidence from previous reviews 31 demonstrates fewer adverse … During the same time, the incidence of adverse pregnancy outcomes decreased from 42.7% to 19.2%, and … https://www.fda.gov/news-events/press-announcements/fda-marketing-authorization-enables-increased-access-first-step-syphilis-diagnosis … Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic … for mother-to-child transmission of syphilis and determinants associated with congenital syphilis and adverse
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/perinatal-depression-interventions-to-prevent
April 22, 2025 - history of physical or sexual abuse, having an unplanned or unintended pregnancy, current stressful life events … health–related factors such as elevated anxiety symptoms or a history of significant negative life events … achieved by addressing and managing negative thoughts, beliefs, and attitudes and by increasing positive events … Depression during pregnancy: a risk factor for adverse neonatal outcomes?
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/depression-in-adults-screening
January 26, 2016 - previously and using clinical judgment in consideration of risk factors, comorbid conditions, and life events … an individual may include emotional suffering, reduced quality of personal relationships, possible adverse … and Treatment
General Adult Population and Older Adults
One trial in general adults reported no adverse … events attributable to screening in a subset of participants with newly-identified depression; 24 none … trial, which focused on the effects of screening alone in postpartum women, specifically reported on adverse