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www.uspreventiveservicestaskforce.org/uspstf/recommendation/cognitive-impairment-in-older-adults-screening
February 25, 2020 - Adverse events were significantly higher in patients receiving AChEIs, and more patients receiving AChEIs … Memantine was better tolerated, with no increase in adverse events or withdrawal rates compared with … Overall, there was no increase in serious adverse events in patients taking AChEIs. … However, some individual studies reported increased rates of serious adverse events, such as bradycardia … Adequate evidence that AChEIs are associated with adverse effects, which overall are small but occasionally
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-risk-factors-behavioral-counseling-july-2017
July 11, 2017 - There was no evidence of greater incidence of serious adverse events, injuries, or falls in intervention … The data on health outcomes (KQ1) and adverse events (KQ4) did not allow for pooled analyses and so were … What adverse events are associated with primary care behavioral counseling interventions to improve diet … Undetected
Low
KQ4: What adverse events are associated with primary care behavioral counseling … No serious adverse events related to behavioral interventions (8 studies).
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/k_QR3hvh2jVSPPLu6Q6m6r
November 13, 2022 - events. … Statin therapy was not significantly associated with
increased risk of serious adverse events (RR, 0.97 … to 1.26%]) (eFigure 9 in the Supple-
ment), serious adverse events (10 trials, n = 55 419; RR, 0.97 … events, serious adverse events, cancer, or el-
evated liver enzyme levels vs placebo or no statin therapy … Statin safety and associated adverse
events: a scientific statement from the American
Heart Association
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary25/screening-for-abnormal-blood-glucose-and-type-2-diabetes-october-2015
April 13, 2015 - 1.73 [CI, 1.57 to 1.92]), and valsartan was associated with increased risk for hypotension-related adverse … events versus placebo in 1 study, 47 with no clear increased risk for serious adverse events. … trials were not designed or powered to specifically assess the risk for serious but uncommon or rare adverse … No evidence on serious psychological or other adverse effects associated with a new diagnosis of diabetes … CV events: 22.9 vs. 22.0 events/1,000 person-years; HR, 1.04 (95% CI, 0.72 to 1.51)
Fair
Pharmacologic
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/g-b8KbTXYe2vnW2zJKGoPU
April 01, 2015 - events. … adverse
events in toddlers consuming iron-
fortified milk and those consuming
unfortified milk were … events. … events, including
gastrointestinal events. … events, including
gastrointestinal events.36
The potential for long-term benefit of
preventing IDA
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breastfeeding-primary-care-interventions-october-2016
October 25, 2016 - For adverse events, harms that could be related to a breastfeeding intervention (e.g., feeling criticized … The data on health outcomes (KQ1) and adverse events (KQ3) did not allow for pooled analyses and so were … Are there adverse events associated with interventions to promote and support breastfeeding? … Only 2 trials 36 , 43 reported adverse events related to a breastfeeding intervention. … Are there adverse events associated with interventions to promote and support breastfeeding?
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/child-maltreatment-primary-care-interventions
March 19, 2024 - The Centers for Disease Control and Prevention also offers “Adverse Childhood Experiences (ACEs) Prevention … for Action: A Compilation of the Best Available Evidence,” a report on the best evidence to prevent adverse … higher (statistically nonsignificant) mortality rates in the intervention group. 1 , 21 Fortunately, events … related to the intervention in either study. 1 , 21 One trial reported miscarriage or termination events … event (mainly clinical events associated with pregnancy and the infancy period) in the intervention
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/perinatal-depression-interventions-to-prevent
February 23, 2023 - intensive care unit admission
Serious harms reported in trials of treatment benefit
Withdrawals due to adverse … events in trials of treatment benefit
KQ 1: Maternal behavioral outcomes (e.g., increase in physical
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www.uspreventiveservicestaskforce.org/uspstf/document/final-modeling-study/aspirin-to-prevent-cardiovascular-disease-preventive-medication
April 26, 2022 - fatal CVD events resulting from nonfatal CVD events that were prevented prior to stopping aspirin. … observed in the aspirin primary prevention trials, but analyses by others have suggested there is no adverse … Net QALY assessments showed strong adverse influence from small disutilities associated with aspirin … Myocardial infarction and ischemic stroke events are nonfatal. … Net events prevented are defined by the net of benefit and harm events, or (nonfatal CVD events + CVD
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/vTJ_Zj3TAkhx45wWUDtNyt
May 01, 2021 - On
average, men experience CVD events earlier in life compared with
women. … Clinicians should recognize that pre-
dictions of 10-year CVD events using the Pooled Cohort Equations … analyses of
trial data, statin therapy was not associated with increased risk
of study withdrawal due to adverse … events or serious adverse
events.13,31 Although observational studies have reported an asso-
ciation … Rosuvastatin to prevent
vascular events in men and women with elevated
C-reactive protein.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan6/high-blood-pressure-in-adults-screening-monitoring-october-2015
September 15, 2013 - How well do home and ambulatory blood pressure monitoring methods predict cardiovascular events compared … What confirmation protocol characteristics define the best prediction of cardiovascular events? … Which methods and associated protocols best predict cardiovascular events? … What are the adverse effects of screening for high blood pressure in adults? … of means)
KQ 3a: Measures of association of blood pressure and fatal or nonfatal cardiovascular events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Nop5YpEpMybx_oNPKC76-X
July 11, 2017 - Among 14 trials of
behavioral interventions that reported on adverse events, none re-
ported any serious … adverse events. … Behavioral Counseling Interventions
Of the 88 trials reviewed by the USPSTF, 14 specifically reported on
adverse … events.3 No trials reported any serious adverse events re-
lated to the counseling intervention. … car-
diovascular events.
-
www.uspreventiveservicestaskforce.org/uspstf/recommendation/obesity-in-adults-interventions
September 18, 2018 - found few events in any group (2 trials [n = 6210]). … Overall, the trials showed no serious harms, and most trials observed no difference in the rate of adverse … events between intervention and control groups. … Serious adverse events were uncommon and similar between groups. 1 Adverse event rates were high in … The higher rate of adverse events in the medication groups resulted in higher dropout rates than in the
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-and-ovarian-cancer-brca-testing-screening-2005
September 15, 2005 - All trials indicated increased risk (2.21 [CI, 1.63 to 2.98]) for thromboembolic events, including pulmonary … Table 6 also describes adverse effects. … Results also show significantly increased risks for thromboembolic events and, for tamoxifen, increased … breast cancer ***
0.38 (0.17-0.54)
0.38 (0.17-0.54)
0.38 (0.17-0.54)
Risk for thromboembolic events … using chemoprevention, n
33 (7.3-59)
412 (92-733)
2,386 (532-4242)
Cases of thrombotic events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/hKRZFsG6c7Kq5ef32cCXa3
February 12, 2019 - It is well established
that perinatal depression can result in adverse short- and long-term effects on … natal depression.23
It is well established that depression during the postpartum
period can lead to adverse … for 1 of
11 adverse effects, with 78% of women taking nortriptyline report-
ing constipation (vs 22% … Depression during pregnancy:
a risk factor for adverse neonatal outcomes? … Antenatal psychosocial risk
factors associated with adverse postpartum family
outcomes.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/2GDCmTe7akyrAHsTMbfz72
May 06, 2022 - prevention clinical land-
scape because of their well-established CVD and mortality ben-
efits and favorable adverse … Feasibility
of conducting a primary prevention trial of
low-dose aspirin for major adverse cardiovascular … events in older people in Australia: results from the
ASPirin in Reducing Events in the Elderly (ASPREE … Adverse effects of
low-dose aspirin in a healthy elderly population. … Association of aspirin
use for primary prevention with cardiovascular
events and bleeding events: a systematic
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/h-w99jVsodSL33kV2h2_qW
April 17, 2018 - Eight studies (n = 4107) evaluat-
ing exercise interventions reported on harms; in general, adverse … events were minor.8,10 The most common adverse events included
pain or bruising related to exercise. … or severe adverse events, although ascertain-
ment of adverse events was unclear.8 One study on a single … psy-
chological intervention reported no adverse events.25 The remain-
ing studies did not report on … harms or adverse events.
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/genital-herpes-serologic-screening
December 02, 2021 - KQ 4: Reduced rates (or frequency) of subclinical HSV-2 viral shedding
KQ 6: Treatment-related adverse … events (e.g., adverse drug reactions related to antiviral medications); psychosocial harms related to
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/h5Tt4jScmQJeHeztmo93hu
February 25, 2020 - -
vational studies (n = 190 076) reported on the harms of treatment
with AChEIs and memantine.16,17 Adverse … Adverse events were significantly higher in patients
receiving AChEIs, and more patients receiving AChEIs … Memantine was better tolerated,
with no increase in adverse events or withdrawal rates compared
with … Overall, there was no increase in serious adverse
events in patients taking AChEIs. … However, some individual studies
reported increased rates of serious adverse events, such as brady-
cardia
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/_SfjkGNHBnLqn8ySe7kAdg
April 01, 2016 - If adverse
bleeding event,
discontinue
aspirin
Screen and treat for
hypertension and
lipid disorders … If CVD event, initiate
secondary CVD
prevention, including
aspirin, if eligible
If adverse
bleeding … .
�� Defined by the net of benefit and harm events or this equation: (nonfatal CVD events + CVD deaths … Rationale for a trial of low-dose aspirin for the primary prevention of
major adverse cardiovascular … events and vascular dementia in the
elderly: Aspirin in Reducing Events in the Elderly (ASPREE).