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www.uspreventiveservicestaskforce.org/uspstf/recommendation/obesity-in-children-and-adolescents-screening-2010
January 15, 2010 - Adverse effects included elevated heart rate, elevated blood pressure, and adverse gastrointestinal effects … An examination of the literature on the harms of weight-management programs found no evidence of adverse … Serious adverse events were reported for 2.7% of the patients who were taking sibutramine and <1% of … Adverse events occurred in 3% of the patients who received orlistat compared with 2% of the patients … Incidence and risk factors for perioperative adverse respiratory events in children who are obese.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/BwAo_shwmJLSRguyWxaXpP
July 01, 2007 - Adverse effects from
lipid-lowering medications and low-fat diets, including potential long-term harms … abnormal lipid levels have been strongly associated with the risk
of coronary heart disease (CHD) events … reduction in 4 studies). 2
Harms of Screening and Treatment
There is poor-quality evidence on the adverse … treatment is based on 81 controlled and
non-controlled studies of treatment that reported a variety of adverse … The adverse effects of
long-term use of lipid-lowering agents (eg, >20 years) have not been studied.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/RPB3rmcS9CK_eXPdzXSxZg
July 01, 2010 - Bisphosphonates are not con
sistently associated with serious adverse events; raloxifene and es
trogen … increase thromboembolic events; and estrogen causes addi
tional adverse events. … no differences
with placebo in rates of serious gastrointestinal adverse events
(107, 108) or withdrawals … Upper gastrointestinal adverse events
and cyclical etidronate. Am J Med. 1997;103:462-7. … Adverse Health Outcomes from Studies, by Medication
Adverse Outcome Evidence
Bisphosphonates
Withdrawals
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary4/colorectal-cancer-screening-2008
October 15, 2008 - Duration of follow-up and methods for determining adverse events varied. … No significant statistical heterogeneity in pooling estimates of serious adverse events. … Duration of follow-up and methods for determining adverse events varied. … No significant statistical heterogeneity in pooling estimates of serious adverse events. … findings considered separate from serious adverse events
CCT = controlled clinical trial; CRC
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adults-preventive-medication-november-2016
November 13, 2016 - used low and moderate doses; under these conditions, statin use was not associated with serious adverse … Myalgia is a commonly reported adverse effect of statins, but placebo-controlled trial data do not support … prevention of CVD, statin therapy was not associated with an increased risk of withdrawal because of adverse … experiencing any serious adverse event. … elevated aminotransferase levels with statin use. 6
Evidence on the association between statin use and adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary52/vitamin-d-and-calcium-to-prevent-fractures-preventive-medication-2013
December 10, 2011 - Adverse Events Associated With Vitamin D With or Without Calcium
The Women's Health Initiative trial … events and were not adequately powered to detect adverse events. … However, these adverse events may or may not be associated with the vitamin D or calcium supplements. … Vitamin D with or without calcium supplementation vs. placebo
Adverse events
All 63 RCTs included … events and were not adequately powered to detect adverse events.
1 RCT in postmenopausal women
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZR66ep5ABbQCUQy7KTDETn
July 01, 2014 - However, trials
found no difference in the risk for serious adverse events or
the number of participants … In
addition, most antiviral adverse events were self-limited
with discontinuation of therapy. … events (12 trials; RR, 0.8
[CI, 0.6 to 1.1]; I2 � 0%) or any adverse event (7 trials;
RR, 0.96 [CI, … Studies did show
an increased risk for withdrawal due to adverse events (9
trials; RR, 4.0 [CI, 1.4 to … events (RR, 2.1 [CI, 1.0 to 4.5]; I2 � 0%), with-
drawals due to adverse events (RR, 7.6 [CI, 1.1 to
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary17/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
December 15, 2013 - Women using tamoxifen and raloxifene had more thromboembolic events than women using placebo (tamoxifen … Coronary heart disease events and stroke were not increased in placebo-controlled trials, although women … Few studies described adverse effects. … In trials, tamoxifen and raloxifene increased thromboembolic events and tamoxifen increased endometrial … Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/chronic-obstructive-pulmonary-disease-screening
May 10, 2022 - events. … None of the included treatment trials that reported adverse effects found significant harms. … events. … None of the included trials that reported adverse effects found significant harms. … 242,588)
Initiation of a LAMA or LABA is associated with an increase in risk of serious cardiovascular events
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/UCajZVxQEKLCgs59HV7ddE
November 01, 2008 - Total serious adverse events
required hospital admission (for example, perforation, ma-
jor bleeding, … Duration of follow-up and methods for determining
adverse events varied. … No significant statistical
heterogeneity in pooling estimates
of serious adverse events. … Duration of follow-up and methods for determining
adverse events varied. … No significant statistical
heterogeneity in pooling estimates
of serious adverse events.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ZTMgupsEkCUuuPVpeGUm45
September 01, 2013 - However, antiviral therapy is given for a
defined duration, serious adverse events are uncommon,
and … adverse events are self-limited and typically resolve af-
ter treatment is discontinued. … These adverse events are self-limited and typically re-
solve after the discontinuation of treatment … Although treatment-related adverse effects were com-
mon, the few serious adverse events reported in … With
regard to harms, the use of liver biopsy is decreasing and
the few serious adverse events reported
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/SaASReVeD_fpHZQbeBZD5s
October 01, 2016 - Although statins in
middle-aged and older adults appear to be relatively
safe and short-term adverse … events generally resolve
with discontinuation of therapy, long-term adverse ef-
fects of statins started … Long-term in-
traindividual cholesterol variability: natural course and adverse im-
pact on morbidity … psychosocial consequences such as anxiety, overdiagnosis,
and others as identified in the literature)
KQ 2: Adverse … function tests or creatine
phosphokinase levels, and others as identified in the literature)
KQ 6: Other adverse
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/intimate-partner-violence-abuse-older-vulnerable-adults
October 29, 2024 - with the control group. 1 In one study, IPV victimization was lower in the intervention group (7.50 events … per person-year) compared with the control group (9.55 events per person-year) at 3 years, but the difference … was not statistically significant (incident rate ratio of average IPV events per person-year, 0.86 [ … events; however, it was unclear whether events were prespecified or how they were monitored. 1 , 51 … events related to study participation by women. 1 , 49 Other trials also reported no harms associated
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/anxiety-adults-screening
June 20, 2023 - events, even if they have proven benefits. … events. … Evidence demonstrated an increase in nonserious harms (defined as any adverse events and withdrawals … due to adverse events). … Serious adverse events were rare and data were insufficient to determine whether pharmacotherapy increased
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/BhnZRA--TRpXdg9_tYmZ_M
April 05, 2016 - Adverse effects were generally mild (eg, dry mouth and cough). … event or serious adverse events were mixed
but generally showed few differences between treated and … events. … events in both groups; 1 study re-
ported higher rates of any adverse event in the tiotropium group … Possible protection by inhaled
budesonide against ischaemic cardiac events in
mild COPD.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/healthy-diet-and-physical-activity-counseling-for-cvd-prevention-in-adults-2012
December 15, 2010 - Key Question 4: Harms
Adverse effects were rarely noted in physical activity counseling trials. … We found no studies designed to assess the adverse effects of dietary counseling or the adverse effects … None of the healthful diet counseling trials reported specific adverse events.
… However, the absolute risk for serious cardiac events related to physical activity seems very small. … events not reported in trials
Good
Good
No specific examination of adverse effects
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/_nVeFxDCT9L-_cnDf_V3fK
July 17, 2018 - , discrimination, or risk reclassification), and serious
adverse events. … Harms included any serious adverse event requiring
unexpected or unwanted medical attention resulting … evidence on major bleeding from
low-dose aspirin
KQ5: hsCRP-Guided Statin Treatment Harms
Serious adverse … but not in other serious
adverse events
There were 3.0% cases of diabetes in the
rosuvastatin group … Limited follow-up This trial should be interpreted in
the context of the larger body of
evidence on adverse
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/obstructive-sleep-apnea-in-adults-screening-january-2017
January 24, 2017 - In addition to mortality, other adverse health outcomes associated with untreated OSA include cardiovascular … mortality independently, beyond the contributions of age, BMI, and other confounding factors. 1 Other adverse … Overall, 2% to 47% of trial participants reported any adverse effects from treatment with CPAP, including … been found to be associated with an increased risk of all-cause and cardiovascular mortality. 1 Other adverse … performance; and decreased quality of life. 1 However, it is unclear what role OSA plays in causing these adverse
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/DCfAJZvNDzSYu7NqLJX2bv
March 01, 2016 - -
ment use vs placebo in risk of any adverse events (93% vs 89%;
RR, 1.05; 95% CI, 0.97-1.13), serious … adverse events (31% vs 30%;
RR, 1.04; 95% CI, 0.72-1.49), or serious ocular adverse events
(8.2% vs … events, but estimates for those outcomes were imprecise. … events in
participants taking
zinc vs placebo. … No increase
in risk of systemic hypertension or
arterial thromboembolic events.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/_q6ZTL2Yg6f6rLp-Re9whD
June 24, 2025 - were lower in the
intervention group (7.50 events per person-year) compared with
Clinical Review & … the control group (9.55 events per person-year) at 3 years, but
the difference was not statistically … significant (incident rate ratio
of average IP V events per person-year, 0.86 [95% CI,
0.73-1.01]).47 … events; however, it was unclear
whether events were prespecified or how they were monitored.1,35,54 … events
related to study participation by women.1,35,52 Other trials also re-
ported no harms associated