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www.uspreventiveservicestaskforce.org/home/getfilebytoken/rQBBkz9CrHh4vp7ZnEkF-t
July 18, 2023 - FH
Ezetimibe 1 (n = 138)
New: 0
Similar rates of total adverse events in
intervention and control groups … 6-11 y
with FH
PCSK9 inhibitor 1 (n = 158)
New: 1
Similar rates of total adverse events in
intervention … events in
intervention and control groups
Consistency NA, imprecise High total adverse events
in both … Limited longer-term evidence shows few withdraw-
als due to adverse events, slightly higher rates of … events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/falls-prevention-community-dwelling-older-adults-interventions
July 21, 2022 - interventions to prevent falls in unselected or increased-risk community-dwelling older adults result in any adverse … Get Up & Go Test, 6-meter timed walk, Functional Reach Test, and Berg Balance Scale)
KQ 2: Minor adverse … events that are reported using nonvalidated and nongeneralizable measures
Followup
Minimum
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-cancer-medications-for-risk-reduction
September 03, 2019 - Medications to reduce risk of breast cancer are effective for women at increased risk but also cause adverse … However, these medications are also associated with adverse effects, 3 and candidates for risk-reducing … All adverse outcomes at all reported follow-up times were considered in an effort to capture potential … short- and long-term adverse effects. … For outcomes of major adverse events, analyses were stratified by active vs posttreatment periods, although
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/aspirin-use-prevent-cardiovascular-disease-colorectal-cancer-preventive-medication-2002
January 15, 2002 - and its likelihood of causing adverse effects. … participants had definite or suspected vascular disease. 12 , 13
From our search for articles on adverse … Adverse Effects of Aspirin Therapy
Hemorrhagic Stroke
The event rates for hemorrhagic strokes, including … effect of aspirin, a reduction in nonfatal myocardial infarction, cannot be directly equated to an adverse … Adverse effects of low-dose aspirin in a healthy elderly population.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening
June 15, 2016 - For KQ3, all trials and observational studies that reported serious adverse events requiring unexpected … Adverse events of computed tomography colonography: an Italian National Survey. … Adverse events after screening and follow-up colonoscopy. … Adverse events after outpatient colonoscopy in the Medicare population. … No studies reported serious adverse events in persons without CTC.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/colorectal-cancer-screening-june-2016
June 15, 2016 - For KQ3, all trials and observational studies that reported serious adverse events requiring unexpected … Adverse events of computed tomography colonography: an Italian National Survey. … Adverse events after screening and follow-up colonoscopy. … Adverse events after outpatient colonoscopy in the Medicare population. … No studies reported serious adverse events in persons without CTC.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/cardiovascular-disease-enhanced-risk-assessment-non-traditional-risk-factors
April 25, 2024 - the comparative performance and agreement between PREVENT (Predicting Risk of cardiovascular disease EVENTs … addition to other risk factors (KQs 1, 3 only)
KQs 4, 5: Interventions aimed at preventing CVD events … placebo
Models predicting mortality only or heart failure only
Outcomes
KQs 1, 4: CVD events … (e.g., myocardial infarction, stroke) and mortality KQ1a: In trials also reporting CVD events, the … , agreement between observed and predicted risks), and decision curve analysis
KQs 3, 5: Serious adverse
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ocULFVqnfy4STqcU2DuPzU
May 18, 2021 - A register-based study: adverse events in
colonoscopies performed in Sweden 2001-2013. … Patient-reported adverse events after colonoscopy
in Norway. … Adverse events after outpatient colonoscopy in the
Medicare population. … Adverse events
after screening and follow-up colonoscopy. … Adverse
events of computed tomography colonography: an
Italian National Survey.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/6jFgJYJSbMc48mj2uKsAhB
October 01, 2014 - None of the dietary intervention studies explicitly reported
adverse events. … Studies of physical activity interventions
reported mostly minor adverse events, and intense physical … events during the trial and 6 spe-
cifically reported no adverse events (6). … Few trials reported
details about the adverse events, but most were minor,
including musculoskeletal … Serious adverse events were
rare.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/oral-health-children-adolescents-screening-preventive-interventions
November 07, 2023 - 12 of 1473 children assigned to varnish reported adverse events (the most common adverse event was nausea … All adverse events were described as self-limited, although 4 children were withdrawn due to mild adverse … One subsequent trial of varnish (n = 5397) reported no adverse events. 83
Only 3 54 , 61 , 67 of 16 … All (n = 775) evaluated a resin-based sealant and reported no adverse events. … sealants reported no adverse events
SDF: SDF associated with increased likelihood of inactive caries
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/ANFp6KBU5kTPRMcMNhMpTj
March 01, 2022 - treatments may
https://www.uspreventiveservicestaskforce.org/Page/Name/grade-definitions
may result in adverse … events such as dry mouth, headache, insomnia, nausea, and tremor
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/drug-use-illicit-screening
June 09, 2020 - Few harms or serious adverse events were reported. … and control groups, including the risk of study discontinuation due to adverse events (3 trials; RR, … of naltrexone or the risk of serious adverse events (2 trials; RR, 0.32 [95% CI, 0.09-1.12]) in trials … events of brief psychosocial interventions identified harms or adverse events. … None of the other psychosocial intervention trials reported on harms or adverse events in adults. 38
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/UaT8AVUSVQwSduNs8TA-_e
June 09, 2020 - events
and evidence that buprenorphine is associated with minor adverse effects (such
as constipation … Few harms or serious adverse events were reported. … and control groups, includ-
ing the risk of study discontinuation due to adverse events (3 trials;
RR … events of brief
psychosocial interventions identified harms or adverse events. … None of the other psychosocial intervention trials reported
on harms or adverse events in adults.38
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/R3y9LSud52CGL8mG4wvxoT
June 09, 2020 - events such as death and adverse events
resulting in hospitalizations or study withdrawal reported at … events.125,130,139 Three studies (n = 638) found no differences in
serious adverse events, but the estimate … events: 3 trials; RR, 1.54
(95% CI, 0.35 to 8.31); I2 = 0%
Serious adverse events: 3 trials; RR, 1.24 … events: 2 trials; RR, 0.33 (95% CI,
0.09 to 1.12); I2 = 0%
Withdrawal due to adverse events: 1 trial … events or study withdrawal due to adverse events vs
placebo or pharmacotherapy.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/9AtjNaSwTXonz49w_DEbNz
November 07, 2023 - Four trials46,54,56,58
(n = 1704) reported no adverse events, and 1 trial55 (n = 2967) re-
ported 12 … of 1473 children assigned to varnish reported adverse
events (the most common adverse event was nausea … All adverse events were described as self-limited, al-
though 4 children were withdrawn due to mild adverse … One
subsequent trial of varnish (n = 5397) reported no adverse events.83
Only 354,61,67 of 16 trials … All (n = 775)
evaluated a resin-based sealant and reported no adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/statin-use-in-adults-preventive-medication
August 23, 2022 - Statin therapy was not significantly associated with increased risk of serious adverse events (RR, 0.97 … to 1.26%]) (eFigure 9 in the JAMA Supplement), serious adverse events (10 trials, n = 55,419; RR, … events, serious adverse events, cancer, or elevated liver enzyme levels vs placebo or no statin therapy … events or muscle symptoms, these findings could be due to expectations regarding adverse effects and … Statin safety and associated adverse events: a scientific statement from the American Heart Association
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/perinatal-depression-preventive-interventions
February 12, 2019 - They reported only the number of events for 1 of the 11 adverse effects collected; constipation differed … events (but data were not shown). … No harms were associated with omega-3 fatty acids, although reports of adverse events were collected … events were reported in either treatment group
Consistency NA, imprecise
Low (DHA)
… events such as conversion to mania
Insufficient
Conducted in the United States
Sertraline
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/lipid-disorders-children-adolescents-screening
May 13, 2021 - . † CVD events are defined as myocardial infarction or ischemic stroke. … in children and adolescents delay or reduce the incidence of health outcomes (cardiovascular disease events … * Cardiovascular disease events are defined as myocardial infarction or ischemic stroke. … positives/negatives
KQ 5 (Treatment Harms): All harms from:
Lipid-lowering medications (e.g., adverse … events, long-term safety, overtreatment)
Lifestyle modifications (e.g., nutritional, psychosocial)
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/high-blood-pressure-adults-children-adolescents-screening-2003
April 01, 2003 - As a result, individuals with higher absolute risk for experiencing future adverse cardiovascular events … experience greater absolute benefit from blood pressure reduction than those at lower risk for future adverse … cardiovascular events. … regimen—are common, but serious adverse drug reactions are rare. … Physicians should take adverse effects into consideration when deciding whether to treat and which treatment
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary34/lipid-disorders-in-children-screening-2007
July 15, 2007 - of screening for dyslipidemia in identifying children/adolescents at increased risk of CHD-related events … the incidence of adult dyslipidemia, and delaying the onset and reducing the incidence of CHD-related events … Information about adverse events was reported in 15 studies of statins, 18 , 19 , 165 , 169 , 172 , 173 … reducing incidence of adult dyslipidemia or delaying the onset and reducing the risk of CHD-related events … There are no trials with long-term follow-up for adult lipid outcomes or CHD-related events.