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1. Evidence Summary: Vitamin D Deficiency in Adults: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/vitamin-d-deficiency-screening
   April 13, 2021 - No studies specified adverse events as primary outcomes. … events, 84 and 1 used multiple methods. 41 Fourteen studies did not report how adverse events were … Total Adverse Events Twenty-four studies (n = 3938) reported overall adverse events. 15-18 , 25 , 35 … Events Sixteen RCTs (n = 3912) reported serious adverse events. 17 , 18 , 21 , 22 , 27 , 36 , 43 , … events, serious adverse events, discontinuations due to adverse events, kidney stones, and other harms

2. Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/XCAMvXugbjnYnGmeF5GtUS
   April 13, 2021 - events Serious adverse events Borgi et al,63 2016 McMullan et al,64 2017 US; good Placebo weekly ( … No studies specified adverse events as primary outcomes. … Total Adverse Events Twenty-four studies (n = 3938) reported overall adverse events (eTable 8 in the … Serious Adverse Events Sixteen RCTs (n = 3912) reported serious adverse events (eTable 9 in the Supplement … events, serious adverse events, discontinuations due to adverse events, kidney stones, and other harms

3. Evidence Summary: Prevention of Acquisition of HIV: Preexposure Prophylaxis | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis
   August 22, 2023 - events (7.5% vs 6.9%) or study drug discontinuation due to adverse events (1.5% vs 1.9%). … events or grade 3 or higher adverse events ( Table 2 ; eTables 1-4 in the  JAMA  Supplement). 6 , 7 … liver-related adverse events, or STIs. … events, discontinuation due to adverse events, or any adverse event: 1 new RCT (n = 5387) Serious … adverse events: 7% vs 7% Discontinuation due to adverse events: 1% vs 2% Any adverse event: 94% vs 94%

4. Evidence Summary: Primary Open-Angle Glaucoma: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/primary-open-angle-glaucoma-screening
   May 24, 2022 - events, and withdrawal due to adverse events and on difference in mean IOP. … (73% vs 72%), ocular adverse events (52% vs 61%), or serious ocular adverse events (2.2% vs 1.7%) (eTable … events, although they were associated with nonserious ocular adverse events (eg, redness, irritation … events, withdrawal due to adverse events, or any adverse event Medical therapy associated with increased … CI, 2.46-5.02]) Inconsistency present for withdrawal due to adverse events and any adverse events

5. Final Evidence Summary: Hepatitis C Virus Infection in Adolescents and Adults: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hepatitis-c-screening
   March 02, 2020 - events (1.9%) and withdrawal due to adverse events (0.4%). … of therapy). 12-55 Adverse Events in Comparative Trials. … due to adverse events, headache, or fatigue. … Rates of other adverse events were highly variable. … events There was 1 serious adverse event (grade 3 joint injury) in 1 study The rate of any adverse

6. Draft Research Plan: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: Preventive Medication | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
   May 23, 2019 - coronary heart disease, peripheral artery disease, and cerebrovascular disease) Cardiovascular disease events … failure Mortality (all-cause, cardiovascular disease–related, cancer-related) KQs 2, 4: Serious adverse … events (as defined by the study, or those likely requiring medical attention) Withdrawals due to adverse … events Nonserious adverse events based on self-report or objective measurements, reported by at least … paradoxical harmful effects on main outcomes (cancer incidence and cardiovascular disease incidence or events

7. Evidence Summary: Prediabetes and Type 2 Diabetes in Children and Adolescents: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/prediabetes-type2-diabetes-children-adolescents-screening
   September 13, 2022 - In 1 study, gastrointestinal adverse events were more commonly reported by those taking metformin than … adverse events, and lactic acidosis ( Table 3 ). … Gastrointestinal Adverse Events Gastrointestinal adverse events were common in both studies. … Other Adverse Events Both studies reported other adverse events; types of events reported (and definitions … events Hypoglycemic events All-cause withdrawals Gastrointestinal adverse events Lactic acidosis

8. Final Research Plan: Chlamydia and Gonorrhea: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan21/chlamydia-and-gonorrhea-screening
   June 15, 2013 - Analytic Framework (Text Description) This analytic framework is a diagram that depicts the events … During the screening, they may experience adverse events, they may be diagnosed with a gonococcal or … Analytic Framework (Text Description) This analytic framework is a diagram that depicts the events … During the screening, they may experience adverse events, they may be diagnosed with a gonococcal or … chlamydia infection, and they may go through treatment, which could lead to adverse effects.

9. Archived: Final Research Plan: Chlamydia and Gonorrhea: Screening | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan21/chlamydia-and-gonorrhea-screening-september-2014
   June 15, 2013 - Analytic Framework (Text Description) This analytic framework is a diagram that depicts the events … During the screening, they may experience adverse events, they may be diagnosed with a gonococcal or … Analytic Framework (Text Description) This analytic framework is a diagram that depicts the events … During the screening, they may experience adverse events, they may be diagnosed with a gonococcal or … chlamydia infection, and they may go through treatment, which could lead to adverse effects.

10. Evidence Summary: Nonpregnant Adolescents and Adults: Human Immunodeficiency Virus (HIV) Infection: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-nonpregnant-adolescents-and-adults1/human-immunodeficiency-virus-hiv-infection-screening
    June 11, 2019 - use based on 4 cohort studies, including the Data Collection on Adverse Events of Anti-HIV Drugs (D: … Hepatic and Renal Adverse Events Analysis of data from the D:A:D study (n = 45,544) found long-term … Some new evidence also indicates that long-term hepatic, renal, and bone (fracture) adverse events are … Mocroft A, Lundgren JD, Ross M, et al; Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study … Comparative safety and neuropsychiatric adverse events associated with efavirenz use in first-line antiretroviral

11. Evidence Summary: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
    June 21, 2022 - The 3 trials that reported the total number of adverse events, 51 , 77 serious adverse events, 77 or … withdrawals due to adverse events 22 , 77 found no group differences. … events, 36 , 39 , 61 , 63 , 65 , 76 , 87 , 90 any serious adverse events, 28 , 40 , 50 , 83 , 86 , … 90 or withdrawal due to adverse events, 40 , 42 , 50 , 67 , 71 , 75 , 83 , 86 , 90 only 1 found an … events, 61 any serious adverse events, 28 and withdrawals due to adverse events 30 , 53 identified

12. Draft Recommendation: Anxiety in Children and Adolescents: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/screening-anxiety-children-adolescents
    April 12, 2022 - Adverse childhood experiences influence the likelihood of suffering from mental health conditions such … Pharmacologic interventions may result in adverse events, while psychological interventions are likely … These trials also showed lower rates of withdrawal due to adverse events and serious adverse events in … Pharmacotherapy studies reported some harms such as more suicide-related events, psychiatric adverse … events, and withdrawals due to adverse events; however, these events were rare and not statistically

13. Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/mf27sR5jgcrqcaY9t8d8Jt
    April 04, 2022 - events, and withdrawal due to adverse events and on difference in mean IOP. … (73% vs 72%), ocular ad- verse events (52% vs 61%), or serious ocular adverse events (2.2% vs 1.7%) … effects Serious adverse events 3 3140 RR, 1.14 (0.60 to 1.99) 32 Withdrawal due to adverse events … events, withdrawal due to adverse events, or any adverse event Medical therapy associated with increased … CI, 2.46-5.02]) Inconsistency present for withdrawal due to adverse events and any adverse events Imprecise

14. Evidence Summary: Prevention of Human Immunodeficiency Virus (HIV) Infection: Preexposure Prophylaxis | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis
    June 11, 2019 - PrEP was associated with an increased risk of renal adverse events (12 trials; RR, 1.43 [95% CI, 1.18 … -1.75]; I 2 = 0%; ARD, 0.56% [95% CI, 0.09%-1.04%]) and gastrointestinal adverse events (12 trials; … RR, 1.63 [95% CI, 1.26-2.11]; I 2 = 43%; ARD, 1.95% [95% CI, 0.48%-3.43%]); most adverse events were … However, for both of these adverse events there was only 1 trial of tenofovir disoproxil fumarate. … events Good Most trials did not report withdrawals resulting from adverse events Composite outcome

15. Archived: Evidence Summary: Prevention of Human Immunodeficiency Virus (HIV) Infection: Preexposure Prophylaxis | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis-june-2019
    June 11, 2019 - PrEP was associated with an increased risk of renal adverse events (12 trials; RR, 1.43 [95% CI, 1.18 … -1.75]; I 2 = 0%; ARD, 0.56% [95% CI, 0.09%-1.04%]) and gastrointestinal adverse events (12 trials; … RR, 1.63 [95% CI, 1.26-2.11]; I 2 = 43%; ARD, 1.95% [95% CI, 0.48%-3.43%]); most adverse events were … However, for both of these adverse events there was only 1 trial of tenofovir disoproxil fumarate. … events Good Most trials did not report withdrawals resulting from adverse events Composite outcome

16. Archived: Evidence Summary: Blood Pressure in Children and Adolescents (Hypertension): Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary16/blood-pressure-in-children-and-adolescents-hypertension-screening-october-2013
    February 15, 2013 - Serious adverse events were rarely reported, and there were no deaths in any of the studies. … No studies of lifestyle modification alone reported adverse events. … event rates or in withdrawals due to adverse events. … a dosing error, serious adverse events were generally not deemed treatment related. … events, including headache (the most commonly reported adverse event), cardiac events, gastrointestinal

17. Draft Research Plan: Chronic Kidney Disease: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/chronic-kidney-disease-screening
    January 19, 2023 - change in albuminuria) KQs 1, 4, 6: Progression to stage 4 or stage 4/5 CKD KQs 2, 5, 8: Any adverse … events Serious adverse events Specific adverse events Renal adverse events KQs 3, 3a:

18. Evidence Summary: Hepatitis B Virus Infection in Adolescents and Adults: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hepatitis-b-virus-infection-screening
    December 15, 2020 - events (7 trials, n = 3136), 35 , 38 , 40 , 41 , 43 , 82 withdrawal due to adverse events (7 trials … events (RR, 2.41 [95% CI, 0.86 to 6.74]), withdrawal due to adverse events (RR, 4.01 [95% CI, 0.86 to … events or experiencing any adverse event vs placebo. … adverse events vs lamivudine, consistent with known adverse effects of interferon-based therapies. … to adverse events: 3 trials, n = 496; RR, 4.44 (95% CI, 0.95-20.77); I 2 =0% 22 , 24 , 27 Any adverse

19. Archived: Tobacco Smoking Cessation in Adults, Including Pregnant Women: Behavioral and Pharmacotherapy Interventions | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions-september-2015
    September 21, 2015 - The USPSTF also evaluated adverse events reported at any time point. … Adverse events related to other forms of behavioral interventions were not reported. … 1.24 [CI, 0.85 to 1.81]) or major cardiovascular adverse events (RR, 1.44 [CI, 0.73 to 2.83]). … events related to product use or any difference in the frequency of adverse events. 8 One study 30 … Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation.

20. Final Research Plan: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
    September 05, 2019 - coronary heart disease, peripheral artery disease, and cerebrovascular disease) Cardiovascular disease events … failure Mortality (all-cause, cardiovascular disease–related, cancer-related) KQs 2, 4: Serious adverse … events (as defined by the study, or those likely requiring medical attention, such as kidney stones, … sarcoidosis, and hip fracture) Withdrawals due to adverse events Nonserious adverse events based … paradoxical harmful effects on main outcomes (cancer incidence and cardiovascular disease incidence or events