-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
March 01, 2011 - Key Question 3: Adverse Events and Side Effects
This Key Question was addressed by 107 studies. … Other adverse events. … We found reports of four types
of adverse events that were not addressed in our
previous evidence report … Moderate Metformin was associated with more frequent GI adverse events than
were DPP-4 inhibitors. … (continued) Moderate Metformin monotherapy was associated with more frequent GI adverse
events than
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
March 01, 2013 - specific adverse events. … The trial reported no other adverse events data. … Other adverse
events reporting was poor. … The study did not report results for adverse events. … conditions as
well as any adverse events, serious adverse events, adverse
events causing withdrawal
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - events (frequency of any adverse events reported in trials)
• Withdrawals due to adverse events, time … • Significant (major) adverse events
Key Question 2:
• Overall adverse events (frequency of any adverse … events reported int rials)
• Withdrawals due to adverse events, time to withdrawal due to adverse events … events, and withdrawal from treatment
due to adverse events. … events and withdrawal
due to adverse events.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - Adverse events 22 Low 1 fair trial: no significant differences in
ECT + rTMS specific adverse events … VNS vs. sham Adverse events 235 Low 1 fair trial: Some differences in specific
adverse events reported … Safety, Adverse Events, and Adherence
(KQ 4)
Direct evidence. … Specific adverse events. … More careful and consistent assessment of adverse
events is required.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
September 01, 2014 - • What factors associated with the patient and her breast
abnormality influence the adverse events of … Events and Additional Surgeries
After Biopsy
In general, adverse events were reported inconsistently … Core needle biopsy was
only infrequently associated with serious adverse events. … adverse events) compared to core needle
biopsy. … Our assessment of the strength of evidence for
adverse events is summarized in Table H.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_executive.pdf
April 01, 2013 - Transfusion carries a
very low risk of infection and other adverse
events, including transfusion reactions … (For example, adverse events that could be
definitively attributed to transfusions were
not reported … Thromboembolic Events
ESA treatment increased the risk of thromboembolic
events (overall strength of … There were fewer thromboembolic and on-study mortality
adverse events when ESA treatment was delayed … Whether there
are subgroups at higher and lower risk of adverse events
and mortality is unclear.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - b: Are there any differences in safety, adverse events, or adherence between
immediate release and … Also,
adverse events may occur at any point after the treatment is received. … Also, adverse events may occur at any
point after the treatment is received.
IV. … events
Withdrawals because of
adverse events
Discontinuation rates because
of adverse events … Serious adverse events
Specific adverse events or
withdrawals because of specific
adverse events
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effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - • We did not detect consistent differences in serious adverse events, number of
reported adverse … events, radiation necrosis, headaches, fatigue and seizures across
interventions. … events, adverse events, radiation
necrosis, headaches, fatigue, seizure, vomiting. … Adverse Events
We found no difference in serious adverse events when comparing WBRT plus SRS
with … Events
Effects of Patient Characteristics
Strengths and Limitations
Implications and Conclusions
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - Serious adverse events are more
common in patients who received lasmiditan than
placebo. … Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … events, nausea, dizziness, and
somnolence, but serious adverse events are
uncommon in randomized trials … Large increases in withdrawal due to
adverse events were seen with oxcarbazepine.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-2007_research-2007-1.pdf
January 01, 2007 - d Safety outcomes considered were overall adverse events, withdrawals due to adverse events, serious … d Safety outcomes: Overall adverse events, withdrawals due to adverse events, serious adverse events … due to adverse events) … Safety and Adverse Events
Rates of serious and overall adverse events
Seven studies met our inclusion … events related to the nervous system,
adverse events related to the cardiovascular system, and adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - • Small to moderate, dose-dependent increases in
withdrawal due to adverse events were found with … Harms and adverse events:
– What are the risks of nonopioid
pharmacologic agents for harms including … overdose, misuse, dependence, withdrawals
due to adverse events, and serious adverse
events, and … specific adverse events? … Other adverse events of interest were not reported
(cognitive effects, misuse, addiction, substance
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
September 23, 2016 - Harms Outcomes:
KQ 1:
§ Overall adverse events (frequency of any adverse events reported in
trials … events (frequency of any adverse events reported in
trials)
§ Withdrawals due to adverse events, … events (frequency of any adverse events reported in trials)
• Withdrawals due to adverse events, time … )
• Significant (major) adverse events
KQ 2:
• Overall adverse events (frequency of any adverse events … reported in trials)
• Withdrawals due to adverse events, time to withdrawal due to adverse events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_overview.pdf
January 17, 2014 - mellitus, what is the
comparative safety of the following treatment options in terms of the following adverse … events and side effects? … addition to updating information on the potential benefits of available treatments, conclusions
regarding adverse … events should also be updated. … There have been a number of potential adverse
events associated with rosiglitazone (e.g. increased
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
May 29, 2025 - Events Other Reported Outcomes Funding Source Risk of Bias
21087411 Bestard, 2011 Prospective cohort … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. … NR
Serious adverse events: none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs … adverse events: 13% (28/215) vs. 19.4% (42/216), OR 0.64 (95% CI 0.38 to 1.04)
Withdrawals due to adverse … events: 4.65% (10/215) vs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
May 29, 2025 - Events Other Reported Outcomes Funding Source Risk of Bias
21087411 Bestard, 2011 Prospective cohort … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. … NR
Serious adverse events: none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs … adverse events: 13% (28/215) vs. 19.4% (42/216), OR 0.64 (95% CI 0.38 to 1.04)
Withdrawals due to adverse … events: 4.65% (10/215) vs.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-202-bronchial-thermoplasty-asthma.pdf
December 01, 2017 - • BT causes more adverse events
(such as worsening of asthma
symptoms, respiratory infections,
and … • Patients treated with BT developed the following
common adverse events: bronchial irritation, chest … Serious adverse events
occurred more frequently in BT-treated patients than in
patients receiving sham … Serious adverse events attributed to BT
were infrequent, and no deaths were reported. … The risk of adverse events is higher early in treatment,
while benefit is typically observed weeks to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dot-plots-methods.pdf
October 01, 2021 - events in
randomized trials, Dr. … The dot plot also shows the number of adverse events in
each group. … For dichotomous outcomes, the dot plots show for each outcome the pooled
absolute rate of events in … events, cancer, diabetes, myalgia, and liver enzyme abnormalities. … events, serious adverse
events, nausea, vomiting, constipation, somnolence, dizziness, and pruritus
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - events
o Maternal
Serious maternal adverse events*
• “Serious” adverse events (including those … events*
o Fetal/infant
Serious fetal/infant adverse events*
• “Serious” adverse events (including … events
o Maternal
Serious maternal adverse events*
• “Serious” adverse events (including those … events*
o Fetal/infant
Serious fetal/infant adverse events*
• “Serious” adverse events (including … ) due
to neonatal/infant adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
January 01, 2006 - COX-2s vs NSAIDs - tolerability
Trial Withdrawals due to
adverse events
Total adverse
events … COX-2s vs NSAIDs - tolerability
Trial Withdrawals due to
adverse events
Total adverse
events … COX-2s vs NSAIDs - tolerability
Trial Withdrawals due to
adverse events
Total adverse
events … Adverse Effects Reported Total withdrawals;
withdrawals due to
adverse events
Tugwell
2004
Not … due to
adverse events
Appendix F.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … events, nausea, dizziness, and somnolence, but
serious adverse events are uncommon in
randomized … Large
increases in withdrawal due to adverse events were
seen with oxcarbazepine. … characterization of what adverse events to
expect.