-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - none
• Final outcomes: diagnosis of ovarian cancer, ovarian cancer mortality, overall
mortality
• Adverse … The safety outcomes will be
framed to help identify adverse events as described in KQ 5. … Figure 2 depicts a schematic view of the flow of events to be considered in the
proposed model. … We will estimate the expected number of clinical events for women in different
populations who use OCs … These clinical events include:
• Incidence and stage distribution of ovarian cancer
• Death from ovarian
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
December 01, 2015 - Contrast-Related Adverse Events
Eight studies (3 RCTs and 5 diagnostic cohort
studies) reported on adverse … The others reported a combination of
nonfatal adverse events. … Maternal/Fetal Adverse Events
Six studies (3 studies of US, 3 of MRI, and 2 of multiple
clinical and … Adverse Events of Testing
Information on harms was often incomplete and poorly
reported. … adverse events, using prespecified criteria
and careful ascertainment methods
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - events
(e.g., suicide or overdose) while undergoing taper, and may not reach tapering goals. … events (including
overdose and mortality)? … events (including
overdose and mortality)
See question 1
Timing Any See question 1
Setting Any … events)
2. … events
2c.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - events
(e.g., suicide or overdose) while undergoing taper, and may not reach tapering goals. … events (including
overdose and mortality)? … events (including
overdose and mortality)
See question 1
Timing Any See question 1
Setting Any … events)
2. … events
2c.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/atrial-fibrillation_research-protocol.pdf
May 22, 2012 - Bleeding events
o Adverse effects of intervention(s):
Adverse effects from drug therapies (e.g … o Bleeding events
• Adverse events:
o Adverse events from drug therapies (e.g.,
hypotension, hypothyroidism … events
outcomes). … The safety outcomes will be framed
to help identify adverse events, including those from drug therapies … , intervention group rates of events, or both.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/tympanostomy-tubes_research-protocol.pdf
November 16, 2015 - Question 3: What adverse events, surgical complications, and sequelae are associated
with inserting … Need for replacement of tympanostomy tubes
• KQ 3: Adverse events, surgical complications, and sequelae … o Intraoperative and immediate postoperative anesthetic and surgical
adverse events
o Medium-term …
events
• Anesthetic and surgical
• Otorrhea
• Blockage of tube lumen
• Granulation tissue …
events
• Ototoxicity
• Allergic reactions
Source: www.effectivehealthcare.ahrq.gov
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
June 01, 2023 - grief-related needs, as well as a large aging population, the COVID-19
pandemic, and more frequent mass trauma events … events or
unintended consequences of the intervention
KQ4: Grief symptoms, resolution of grief disorder … events or unintended consequences of the
intervention
Clinician or organizational
barriers to, opinions … events as well as the
comparative effectiveness and safety of different interventions. … events associated with the
screening procedure; administrative time; inter-rater reliability;
• KQ2
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1312.pdf
January 01, 2016 - Although some experts believe the risk of adverse
ES-7
events would affect patient and clinician … No serious adverse events were reported. … -
emergent adverse events were reported most frequently, but were seldom treatment
limiting. … The incidence of serious adverse events potentially related to systemic
vascular endothelial growth … The main nonocular AEs [adverse
events] were nasopharyngitis (18.8%) and hypertension (10.4%).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prioritized-research-agenda.pdf
October 01, 2021 - Are there specific SDOH that are associated with higher rates of adverse events (AEs)
from pharmacological … Are there variations in the rates of response, remission, recurrence, and adverse events
across treatments … What is the relationship between antidepressant treatment and longer-term adverse
outcomes, such as … diabetes, decreased bone mineral density, and cardiovascular events? … Do rates of remission, response, recurrence, and adverse events differ according to the
care model in
-
effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence-quiz.ppt
May 29, 2025 - suited for testing hypotheses of whether one intervention is associated with a greater risk for an adverse … are well suited for testing hypotheses that one intervention is associated with a greater risk for an adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
November 27, 2012 - It
was outside the scope of this review to search
the FDA’s adverse events database. … have the authors report on adverse
event data submitted to the FDA? … It was outside the scope of this review
to search the FDA’s adverse events database. … Peer Reviewer
#6
Results Page 119: Did the mixed treatment analysis include adverse drug
events? … a network
meta-analysis for other adverse effects.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - Table B
summarizes findings on adverse events and safety. … See “Potential adverse effects
and complications” section. … The manufacturers
of risperidone pooled four RCTs and found that
cerebrovascular adverse events were … events
was three times higher in olanzapine patients than
in placebo patients. … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - We found high strength of evidence that the
rates of gastrointestinal adverse events were similar for … Pooled odds ratios of gastrointestinal adverse events and strength of evidence for
monotherapy and metformin-based … for specific adverse events of interest: urinary
tract infections, genital mycotic infections, renal … events. … Medication use leading
to emergency department visits for adverse drug events in older
adults.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_clinician.pdf
February 01, 2016 - a systematic review evaluating the evidence regarding the efficacy, comparative effectiveness, and adverse … events, coexisting symptoms, and availability of
treatments. … Adult Dosing Mechanism of Action Common Adverse Effects Contraindications
Acamprosate Oral: 666 mg ( … causing accumulation of
acetaldehyde during alcohol consumption,
which, in turn, produces various adverse … Clinicians are advised to refer to the prescribing
information sheet for additional information on adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer-therapy_executive.pdf
May 01, 2013 - events? … events were added to the list of harms. … events? … events. … events for KQ2.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_executive.pdf
January 01, 2011 - on harms.23,26,35,40-43 Specifically, three studies reported no
adverse events associated with iron … Only the Japanese trial specifically monitored
the adverse events associated with study medication; … events associated with iron therapy during the
study periods … Insufficient • Only 1 RCT explicitly monitored the adverse events:
– There were a total of three … events secondary to venipuncture,
effects of iron overload with iron treatments, and cardiovascular
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
July 26, 2012 - protocols for scheduled
imaging, eligible trials did not report results for
imaging of symptomatic stone events … These were rare events
without sufficient evidence to suggest that risk
of death was associated with … events, and predefined
adverse events including effects on comorbid
conditions in all randomized participants … Although one could
argue that symptomatic stone events comprise a more
reproducible, easily countable … not
documented radiographically, may not actually reflect a stone
event at all, 2) multiple stone events
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - events caused by the
persistent dopamine receptor blockade by FGAs. … events associated with an antipsychotic are
likely to be consistent regardless of the indication for … ) or for having a
pathologically prolonged QT interval (14 studies, 2425
patients; events in 19 of … Exclusion of patients
with comorbidities, a history of various adverse events,
and/or less-than-moderate … Recognizing and
monitoring adverse events of second-generation antipsychotics
in children and adolescents
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_disposition-comments.pdf
May 27, 2010 - events, tumor control and survival:
“There are considerable obstacles to conducting
randomized, … events, tumor control and survival:
“There are considerable obstacles to conducting
randomized, … events, tumor control and survival:
“There are considerable obstacles to conducting
randomized, … • CTCAE is a broad dictionary of adverse event terms and grades. … Events
Comparative Effectiveness Research Review Disposition of Comments Report
Research
-
effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
March 21, 2016 - (pg. 35)
Public Reviewer 3:
Fred Kurtz,
Medtronic
General
comments
Adverse Events Associated … While your review is comprehensive, most sacral nerve
stimulation reported adverse events are resolved … Published
adverse events and Medtronic’s FDA labeling for the
InterStim device may further inform the … TEP 5
Results Adverse Events are addressed in the text but perhaps an
additional column could be … Same as above for nonsurgical tables
TEP 7
Results The adverse events section was clearly presented