-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - Some reviewers felt we should limit VTE events to symptomatic events while others did
not feel this … Deep vein thrombosis (asymptomatic or symptomatic, proximal or distal)
Harms, Adverse events
1 … spine surgery
Intermediate outcomes
DVT (asymptomatic or
symptomatic, proximal or
distal)
Adverse … The remaining KQs 4-11 explore the impact of thromboprophylaxis on final health
outcomes and adverse … VTE) and adverse
events (i.e. bleeding) in the trials will be considered for subgroup and sensitivity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - Some reviewers felt we should limit VTE events to symptomatic events while others did
not feel this … Deep vein thrombosis (asymptomatic or symptomatic, proximal or distal)
Harms, Adverse events
1 … spine surgery
Intermediate outcomes
DVT (asymptomatic or
symptomatic, proximal or
distal)
Adverse … The remaining KQs 4-11 explore the impact of thromboprophylaxis on final health
outcomes and adverse … VTE) and adverse
events (i.e. bleeding) in the trials will be considered for subgroup and sensitivity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
October 01, 2022 - functioning, quality of life, sleep,
substance use, suicide and self-directed violence, withdrawal due to adverse … events, serious adverse events
• Timing:
o No limitation on study duration or length of follow up … National estimates of exposure to traumatic
events and PTSD prevalence using DSM-IV and DSM-5 criteria … Mean number of trauma types and traumatic events experienced per participant
t. % with suicidal ideation … Harms outcomes (withdrawals due to adverse events, serious adverse events)
14
APPENDIX
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
January 01, 2021 - functioning, quality of life,
sleep, substance use, suicide and self-directed violence, withdrawal due to
adverse … events, serious adverse events
• Timing:
o No limitation on study duration or length of follow up … National estimates of exposure to
traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria … Mean number of trauma types and traumatic events experienced per participant
t. % with suicidal ideation … Harms outcomes (withdrawals due to adverse events, serious adverse events)
APPENDIX C.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/tympanostomy-tubes_research-protocol.pdf
November 16, 2015 - Question 3: What adverse events, surgical complications, and sequelae are associated
with inserting … Need for replacement of tympanostomy tubes
• KQ 3: Adverse events, surgical complications, and sequelae … o Intraoperative and immediate postoperative anesthetic and surgical
adverse events
o Medium-term …
events
• Anesthetic and surgical
• Otorrhea
• Blockage of tube lumen
• Granulation tissue …
events
• Ototoxicity
• Allergic reactions
Source: www.effectivehealthcare.ahrq.gov
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
September 26, 2014 - Prespecified
interim analysis of major adverse cardiovascular events is anticipated by mid-2015 and … Experts also expressed
concerns regarding potential adverse events, including cataracts and increased … No
serious adverse events were reported. … However, several experts expressed concerns regarding potential adverse events,
including cataracts … Clinician
acceptance is likely to be moderated by the potential for adverse events, experts thought
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - events. … In addition, adverse events may occur at any point after treatment is received. … events. … events
h) Safety blood indices
Source: www.effectivehealthcare.ahrq.gov
Published Online … events (AE); serious AE (SAE); anaphylaxis]
i) Adverse events (AE): An injury caused by medical
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
December 11, 2012 - treatment goals for patients with UA/NSTEMI involve the elimination of
ischemia and the prevention of adverse … events (death, recurrent ischemia, or myocardial
infarction [MI]). … )
○ Adverse effects of treatments
1. … Adverse drug reactions (thrombocytopenia, allergic drug reaction)
2. … The safety outcomes will be framed to help identify adverse events, including
adverse drug reactions
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder-disposition-160504.pdf
December 08, 2015 - Adverse events assessment is one of
the great limitations of this body of
literature. … Only 1 study used an
objective scale for adverse events
assessment. … Rather
than specify which serious adverse
events were not reported, with the
exception of suicidal … Adverse events assessment is one of
the main limitations of this body of
evidence. … Some adverse events may be idiosyncratic
to a particular treatment (e.g., phototoxic rash with St.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
January 01, 2020 - greatest risk for weight gain including by baseline weight
(normal/overweight); age groups; life events … disorders, activity related injuries
including fracture, and adverse events of medications (e.g., diarrhea … For infrequent adverse effects, we will calculate the
Peto odds ratios when the combined number of events … will report on subgroups of interest including baseline weight
(normal/overweight); age groups; life events … #http://www.niehs.nih.gov/news/events/pastmtg/2004/built/.
31.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - events
(e.g., suicide or overdose) while undergoing taper, and may not reach tapering goals. … events (including
overdose and mortality)? … events (including
overdose and mortality)
See question 1
Timing Any See question 1
Setting Any … events)
2. … events
2c.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief2-opioid-withdrawal.pdf
April 01, 2021 - events
(e.g., suicide or overdose) while undergoing taper, and may not reach tapering goals. … events (including
overdose and mortality)? … events (including
overdose and mortality)
See question 1
Timing Any See question 1
Setting Any … events)
2. … events
2c.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-treatment_executive.pdf
August 01, 2012 - Outcomes and effect
modifiers
• Primary outcomes: major adverse cardiovascular
events such as death … • Adverse effects of interventions: adverse
drug reactions, radiation exposure, access site
complications … events resulting
from medical therapy and revascularization. … A
majority of sex-specific reporting was on the composite
outcome of major cardiovascular adverse events … Systematic reporting
of adverse events in publications—in total and by sex—
should continue to clarify
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
October 12, 2015 - adverse!effects!of!treatments!
!! OHSS!
!! Surgical!complications!
!! Adverse!effects!of! … events
outcomes). … The safety outcomes
will be framed to help identify adverse events, including those from medical therapies … interest; that is, important characteristics are those that affect baseline (control group) rates of
events … , intervention group rates of events, or both.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1312.pdf
January 01, 2016 - Although some experts believe the risk of adverse
ES-7
events would affect patient and clinician … No serious adverse events were reported. … -
emergent adverse events were reported most frequently, but were seldom treatment
limiting. … The incidence of serious adverse events potentially related to systemic
vascular endothelial growth … The main nonocular AEs [adverse
events] were nasopharyngitis (18.8%) and hypertension (10.4%).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
July 24, 2013 - What are the adverse effects or harms associated with imaging-based surveillance
strategies? … o Key Questions 1d, 2d, and 3d (Adverse Events or Harms)
Adverse effects or harms associated with … the imaging techniques (e.g., test-related
anxiety, adverse events secondary to venipuncture, contrast … Events or
Harms
Adverse effects or harms associated with the imaging
techniques (e.g., test-related … anxiety, adverse events
secondary to venipuncture, contrast allergy, exposure to
radiation)
Adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
April 01, 2022 - Serious adverse events were not reported. … Opioid medication
discontinuation and risk of adverse opioid-
related health care events. … Harms and Adverse Events:
a. … events, serious
adverse events, overdose, substance misuse,
substance use disorder related outcomes … Harms and Adverse Events:
Key Question 3. Dosing Strategies:
Key Question 4.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cystic-fibrosis-hgh_research-protocol.pdf
August 22, 2008 - KQ 4: In patients with CF, what is the frequency of nonmalignant serious adverse effects
resulting from … KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted
by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of
treatment … Adverse events associated with rhGH use are also evaluated, including altered
glucose metabolism, development … Important health outcomes in KQ2 and adverse events in KQ4 associated with rhGH will be
meta-analyzed
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-survivor-care-transition_research-protocol.pdf
March 27, 2013 - , detection, surveillance, or treatment services.6 This fragmentation of care may have
significant adverse … events and unintended consequences of survivorship care
4. … events
• Outcomes attributable to the cancer
treatment (except for adverse
events and other long-term … events
Timing • Length of survivorship care services
Source: http://effectivehealthcare.ahrq.gov … It
seeks to both prevent and control adverse cancer diagnosis and treatment-related outcomes such
as
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_clinician.pdf
July 01, 2017 - strength of evidence (SOE) from
RCTs that marine oil supplements do not affect the risk of
major adverse … cardiac events (MACE), all-cause death, sudden
cardiac death, revascularization, or high blood pressure … and biomarkers of
various omega-3 FAs individually and in combination with
regard to long-term CVD events … of
Evidence
Marine oil
(EPA + DHA ±
DPA)a
[mainly
supplements or
supplemented
food]
Major adverse … cardiac events No effect in RCTs
No association in Obs-intake
Unclear association in Obs-bio
0.96