-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
July 18, 2011 - events
18
limit their use in many EDs. … the
phenothiazines and investigate their side effects, particularly akathisia and extrapyramidal
events … Addressing sedation as an adverse event. … Question 4
Does the development of adverse events (especially akathisia) differ following the … Adverse events may occur at any point after the treatment is received and will be
assessed up to 3
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - events (hepatotoxicity,
nephrotoxicity, hypertension, dyslipidemia, malignancy,
and teratogenicity … events and previously used treatment modalities when
making therapeutic decisions. … events, sample size, and use of intention-to-
treat analysis. … Adverse events were not evaluated
in these studies. … cardiovascular events, and psychological outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-211-rheumatoid-arthritis-disposition-comments.pdf
December 20, 2018 - events and serious adverse events.” --- But there are
five trials. … Peer
Reviewer #1
Results Then Lines 25-26: “.. and discontinuation attributable to
adverse events … of the data since the
1.2% vs. 1.2% are discontinuation rates due to serious
adverse events, not the … percentage of serious adverse
events. … NWMA was
provided for withdrawals and withdrawals due to adverse
events, but not for serious adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-protocol-2021_0.pdf
January 01, 2021 - functioning, quality of life,
sleep, substance use, suicide and self-directed violence, withdrawal due to
adverse … events, serious adverse events
• Timing:
o No limitation on study duration or length of follow up … National estimates of exposure to
traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria … Mean number of trauma types and traumatic events experienced per participant
t. % with suicidal ideation … Harms outcomes (withdrawals due to adverse events, serious adverse events)
APPENDIX C.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd4-final-protocol.pdf
October 01, 2022 - functioning, quality of life, sleep,
substance use, suicide and self-directed violence, withdrawal due to adverse … events, serious adverse events
• Timing:
o No limitation on study duration or length of follow up … National estimates of exposure to traumatic
events and PTSD prevalence using DSM-IV and DSM-5 criteria … Mean number of trauma types and traumatic events experienced per participant
t. % with suicidal ideation … Harms outcomes (withdrawals due to adverse events, serious adverse events)
14
APPENDIX
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management-1_research-2007.pdf
January 01, 2007 - events or potential
adverse events. … drug events.4, 57, 58 Despite this,
these programs formed the backbone of most of the MTM programs, … Fatal adverse drug events: the paradox of drug
treatment. J Intern Med 2001;250(4):327-41.
19. … Adverse drug events in emergency department
patients. … Role of
pharmacist counseling in preventing adverse drug
events after hospitalization.
-
effectivehealthcare.ahrq.gov/sites/default/files/vte-protocol-8-4-10.pdf
February 01, 2008 - Some reviewers felt we should limit VTE events to symptomatic events while others did
not feel this … Deep vein thrombosis (asymptomatic or symptomatic, proximal or distal)
Harms, Adverse events
1 … spine surgery
Intermediate outcomes
DVT (asymptomatic or
symptomatic, proximal or
distal)
Adverse … The remaining KQs 4-11 explore the impact of thromboprophylaxis on final health
outcomes and adverse … VTE) and adverse
events (i.e. bleeding) in the trials will be considered for subgroup and sensitivity
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/blood-clots-hip-knee-surgery_research-protocol.pdf
February 01, 2008 - Some reviewers felt we should limit VTE events to symptomatic events while others did
not feel this … Deep vein thrombosis (asymptomatic or symptomatic, proximal or distal)
Harms, Adverse events
1 … spine surgery
Intermediate outcomes
DVT (asymptomatic or
symptomatic, proximal or
distal)
Adverse … The remaining KQs 4-11 explore the impact of thromboprophylaxis on final health
outcomes and adverse … VTE) and adverse
events (i.e. bleeding) in the trials will be considered for subgroup and sensitivity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
December 01, 2012 - events
(Table D). … Other adverse events are
listed in Table 9 of the full report. … SBRT Insufficient One study reported no major complications.69 Other adverse events are reported in … Key Points
• No conclusions on overall survival, quality of life,
or adverse events can be drawn from … events for all KQs.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
January 01, 2020 - greatest risk for weight gain including by baseline weight
(normal/overweight); age groups; life events … disorders, activity related injuries
including fracture, and adverse events of medications (e.g., diarrhea … For infrequent adverse effects, we will calculate the
Peto odds ratios when the combined number of events … will report on subgroups of interest including baseline weight
(normal/overweight); age groups; life events … #http://www.niehs.nih.gov/news/events/pastmtg/2004/built/.
31.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
October 01, 2015 - events. … events.28
Clinical trials: Pirfenidone. … events could pose barriers to pirfenidone and nintedanib
use. … However, two clinical experts
stated that adverse events could reduce patient acceptance.58,64 One … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder-disposition-160504.pdf
December 08, 2015 - Adverse events assessment is one of
the great limitations of this body of
literature. … Only 1 study used an
objective scale for adverse events
assessment. … Rather
than specify which serious adverse
events were not reported, with the
exception of suicidal … Adverse events assessment is one of
the main limitations of this body of
evidence. … Some adverse events may be idiosyncratic
to a particular treatment (e.g., phototoxic rash with St.
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
September 26, 2014 - Prespecified
interim analysis of major adverse cardiovascular events is anticipated by mid-2015 and … Experts also expressed
concerns regarding potential adverse events, including cataracts and increased … No
serious adverse events were reported. … However, several experts expressed concerns regarding potential adverse events,
including cataracts … Clinician
acceptance is likely to be moderated by the potential for adverse events, experts thought
-
effectivehealthcare.ahrq.gov/sites/default/files/diverticulitis-comments.pdf
October 12, 2020 - of hospital stay, diverticulitis-
related morbidities, pain and tenderness,
rehospitalization, or adverse … events. … of hospital stay, diverticulitis-
related morbidities, pain and tenderness,
rehospitalization, or adverse … events and
death. … check the certainty of evidence that is
reported under key points for risk of
recurrence and risk of adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol-amendment.pdf
September 19, 2023 - These events may be
heralded by clear premonitory signs and symptoms that create opportunities to recognize … level of care (ICU,
procedural area [e.g., operating room,
interventional radiology]
• Serious adverse … Incidence and preventability of adverse events requiring
intensive care admission: a systematic review … The relationship between early emergency team calls and serious
adverse events. … These events may be heralded by clear premonitory signs and symptoms that create op...
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/angina-heart-attack-treatments_research-protocol.pdf
December 11, 2012 - treatment goals for patients with UA/NSTEMI involve the elimination of
ischemia and the prevention of adverse … events (death, recurrent ischemia, or myocardial
infarction [MI]). … )
○ Adverse effects of treatments
1. … Adverse drug reactions (thrombocytopenia, allergic drug reaction)
2. … The safety outcomes will be framed to help identify adverse events, including
adverse drug reactions
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Comparators: Any comparator, or usual care
Outcomes
Primary: efficacy outcomes (i.e., pain, overall function, adverse … effects (e.g., dizziness, nausea, sedation, cannabis use disorder, serious adverse events)
Secondary … Cannabis products associated with increased risk of adverse events (dizziness, sedation, nausea); studies … pharmacologic therapy/nonpharmacologic therapy
Outcome: Pain, function, satisfaction, quality of life, and adverse … events (≤ 4 weeks).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
October 12, 2015 - adverse!effects!of!treatments!
!! OHSS!
!! Surgical!complications!
!! Adverse!effects!of! … events
outcomes). … The safety outcomes
will be framed to help identify adverse events, including those from medical therapies … interest; that is, important characteristics are those that affect baseline (control group) rates of
events … , intervention group rates of events, or both.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
November 01, 2009 - Adverse events, harms, and safety issues reported ..................................................30 … Four reviewers identified studies of any design describing clinical outcomes or adverse
events with … Seventy-five percent of studies (188) reported the adverse events. … Not all studies adopted
established scales to evaluate adverse events. … Adverse events, harms, and safety issues reported
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_executive.pdf
January 27, 2012 - events. … Evidence for many potential adverse events was
insufficient to determine whether the risk was increased … For most of the specific adverse events, point estimates
favored placebo (i.e., there were more adverse … In head-to-head studies, the risk of withdrawal
due to adverse events was not significantly different … Individual trials of
topiramate reported increased risk of many adverse events,
including paresthesias