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effectivehealthcare.ahrq.gov/products/hepatitis-c/research-protocol
November 30, 2011 - In addition, psychiatric, gastrointestinal, dermatological, and hematologic adverse effects underlie … of life, hepatic cirrhosis, hepatocellular carcinoma, and liver transplants
Transmission of HCV
Adverse … effects of intervention(s)
Harms from antiviral treatment, including withdrawals due to adverse events … , serious adverse events such as severe neutropenia, psychological adverse events, flu-like symptoms, … and hematological adverse events
Timing and Setting:
No minimum timing and all settings included
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_clinician.pdf
July 01, 2016 - This is a summary of a systematic review evaluating the evidence regarding the potential benefits and adverse … Noninvasive nonsurgical fecal incontinence treatments
had few minor adverse effects. … Longer term information on benefits and
adverse effects would better inform clinical decisions for … Substantial and life-
altering adverse events sometimes occur after surgery for
fecal incontinence, … and these events were underidentified
in randomized controlled trials (RCTs) alone.
�� Addressing the
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
April 01, 2013 - For categorical
variables, we abstracted the number of events among
treatment groups to calculate rates … We used default software
continuity coefficients for 0 events and intention to
treat as recommended … The number
of avoided or excessive events per population of 1,000 is
the difference between the two … Time course of adverse
events most commonly associated with topiramate for migraine
prevention. … A systematic review of
adverse events in placebo groups of anti-migraine clinical trials.
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effectivehealthcare.ahrq.gov/products/adhd-medicines-risks/abstract
January 01, 2005 - Food and Drug Administration review of its Adverse Event Reporting System (AERS) for cases of sudden … identifying important cardiovascular outcomes, and assessing the overall risk of serious cardiovascular events … ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med 2011 Nov 1.
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effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Withdrawals due to adverse events were below 10% in all
treatment groups. … Withdrawals due
to adverse events were below 10% in both treatment groups. … The rates of serious adverse events in the two groups were
similar. … Headache, nausea, and dizziness were the most common
lorcaserin-related adverse events. U.S. … Common adverse
events were headache, back pain, nasopharyngitis, and nausea.
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effectivehealthcare.ahrq.gov/products/stroke-afib-update/research-2018
October 30, 2018 - CHADS 2 , CHA 2 DS 2 -VASc, and ABC risk scores have the best evidence to support prediction of stroke events … Higher adverse events (excessive bleeding or procedure-related complications) were observed with LAA … Direct oral anticoagulants (specifically apixaban and dabigatran) demonstrate reductions in stroke events … and reductions (apixaban) or similar (dabigatran) rates in bleeding events when compared with warfarin … Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
November 03, 2011 - o Treatment discontinuation due to adverse effects. … For categorical variables we will abstract the number of events among treatment
groups to calculate … percent CI, we will calculate the
relative risk and absolute risk difference from the abstracted events … Time course of adverse events most commonly
associated with topiramate for migraine prevention. … A systematic review of adverse events in placebo
groups of anti-migraine clinical trials.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - • Acute adverse events (AEs) were significantly fewer with PBI compared with
WBI, with no apparent … This highlights the need to investigate outcomes of
PBI among patients with adverse risk factors. … These advancements
result in improved dose homogeneity that may lower the risk for adverse events. … PBI is associated with
fewer acute adverse effects, but the risk of IBR among patients treated with … PBI who
have adverse clinical or pathologic features is unclear.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
April 01, 2013 - cardiovascular events (MACE)
and coronary dissection were significantly
lower in the overall analysis … There was a paucity of trials available to
evaluate adverse events with any of the
embolic protection … conventional PCI
25 trials including
5,534 patients
Major adverse cardiac events were
significantly … events (MACE) and coronary dissection were
significantly lower in the overall analysis and the good … There was a paucity of trials available to evaluate
adverse events with any of the embolic protection
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effectivehealthcare.ahrq.gov/products/osteoporosis-bone-fracture/research-protocol
May 14, 2010 - events will be analyzed for KQ4. … Outcomes:
Any reported harms/adverse events (AEs) that can be directly associated with use of an agent … KQ4 assesses the evidence for adverse effects of treatment. … Events.9 Then, a verbatim account of the AE will be recorded on the form. … Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0.
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effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
December 01, 2013 - Withdrawals due to adverse events were below 10% in all
treatment groups. … Withdrawals due
to adverse events were below 10% in both treatment groups. … The rates of serious adverse events in the two groups were
similar. … Headache, nausea, and dizziness were the most common lorcaserin-related
adverse events. U.S. … Common
adverse events were headache, back pain, nasopharyngitis, and nausea.
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effectivehealthcare.ahrq.gov/products/lung-cancer-nonsurgical-therapies/research
June 12, 2013 - sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverse … events, and quality of life among our populations of interest. … Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of
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effectivehealthcare.ahrq.gov/products/allergy-seasonal/research-protocol
March 08, 2012 - events. … events resulting from systemic absorption, such as impaired bone growth, reduced height, suppression … events in SAR research. … Additionally, systematic reviews and meta-analyses that specifically assess adverse events associated … events, and results.
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effectivehealthcare.ahrq.gov/products/hip-fracture-pain/research-protocol
December 09, 2009 - For KQ3, all reported adverse events (AE) that are directly or indirectly associated to the intervention … Also, adverse events may occur at any point after the treatment is received (e.g., medication adverse … events outcomes
AE related to the pain management intervention
Mental status
Health-related … For the questions on safety and adverse effects, in addition to the above databases, we will search the … National Library of Medicine's TOXLINE® (1965 to present), and Canada’s Adverse Drug Reaction Database
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
January 01, 2019 - events, side effects of interventions (any time frame)
o Hospitalization comparison:
Hospital-based … infections and other harms
o Antibiotics comparisons:
Side effects/adverse events attributable … events related to procedures, including bleeding and catheter
infections
Need for second procedures … o N≥30/arm*
• Single group studies
o Only for adverse events
o N>100†
• Longitudinal (Exclude: … events, and side effects of colonoscopy (e.g. perforation, bleeding)
Modifiers/Subgroups of interest
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effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
April 01, 2020 - in frequency of intervention-related
adverse events or withdrawals. … Table 64 in the full
report summarizes reported adverse events for
each intervention. … No serious intervention-related adverse events
leading to death or disability or requiring intensive … Evidence was low
or insufficient for other adverse events. … Acupuncture-related
adverse events: a systematic review of the Chinese
literature.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-muscle-invasive_executive.pdf
June 01, 2015 - events;
withdrawals due to adverse events; and sources of funding. … Although
cisplatin is nephrotoxic, renal adverse events were not
well reported.28 No study compared … radical cystectomy:
adverse events
Insufficient
There was insufficient evidence from 4 studies of … with grade 3 or 4
hematological adverse events. … Adjuvant
chemotherapy
vs. no adjuvant
chemotherapy:
adverse events
Insufficient
Harms were poorly
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
March 08, 2012 - events. … events resulting from systemic
absorption, such as impaired bone growth, reduced height, suppression … events in SAR research. … Additionally, systematic reviews and
meta-analyses that specifically assess adverse events associated … events, and results.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
February 01, 2018 - Example binary data for effect size computation
Treatment
Events in
Treatment
Group
Treatment
n … Number-Needed-to-Treat-Related Concepts for Assessing Treatment Efficacy in the
Presence of Treatment-Induced Adverse … Events. … Number-Needed-to-Treat-Related Concepts for Assessing Treatment Efficacy in the
Presence of Treatment-Induced Adverse … Events.
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effectivehealthcare.ahrq.gov/sites/default/files/topic-refinement.ppt
March 01, 2010 - The adverse events include altered glucose, diabetes mellitus, lymphoid overgrowth, and malignancy. … KQ 6: In patients with CF, how are efficacy, effectiveness, safety, or adverse events impacted by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety, or adverse events of treatment … Key question 6: In patients with CF, how are efficacy, effectiveness, safety, or adverse events impacted … Key question 7: In patients with CF, how do the efficacy, effectiveness, safety, or adverse events of