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  1. effectivehealthcare.ahrq.gov/products/hepatitis-c/research-protocol
    November 30, 2011 - In addition, psychiatric, gastrointestinal, dermatological, and hematologic adverse effects underlie … of life, hepatic cirrhosis, hepatocellular carcinoma, and liver transplants Transmission of HCV Adverse … effects of intervention(s) Harms from antiviral treatment, including withdrawals due to adverse events … , serious adverse events such as severe neutropenia, psychological adverse events, flu-like symptoms, … and hematological adverse events Timing and Setting: No minimum timing and all settings included
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_clinician.pdf
    July 01, 2016 - This is a summary of a systematic review evaluating the evidence regarding the potential benefits and adverse … Noninvasive nonsurgical fecal incontinence treatments had few minor adverse effects. … Longer term information on benefits and adverse effects would better inform clinical decisions for … Substantial and life- altering adverse events sometimes occur after surgery for fecal incontinence, … and these events were underidentified in randomized controlled trials (RCTs) alone. �� Addressing the
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-adults-executive-130408.pdf
    April 01, 2013 - For categorical variables, we abstracted the number of events among treatment groups to calculate rates … We used default software continuity coefficients for 0 events and intention to treat as recommended … The number of avoided or excessive events per population of 1,000 is the difference between the two … Time course of adverse events most commonly associated with topiramate for migraine prevention. … A systematic review of adverse events in placebo groups of anti-migraine clinical trials.
  4. effectivehealthcare.ahrq.gov/products/adhd-medicines-risks/abstract
    January 01, 2005 - Food and Drug Administration review of its Adverse Event Reporting System (AERS) for cases of sudden … identifying important cardiovascular outcomes, and assessing the overall risk of serious cardiovascular events … ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med 2011 Nov 1.
  5. Obesity (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - Withdrawals due to adverse events were below 10% in all treatment groups. … Withdrawals due to adverse events were below 10% in both treatment groups. … The rates of serious adverse events in the two groups were similar. … Headache, nausea, and dizziness were the most common lorcaserin-related adverse events. U.S. … Common adverse events were headache, back pain, nasopharyngitis, and nausea.
  6. effectivehealthcare.ahrq.gov/products/stroke-afib-update/research-2018
    October 30, 2018 - CHADS 2 , CHA 2 DS 2 -VASc, and ABC risk scores have the best evidence to support prediction of stroke events … Higher adverse events (excessive bleeding or procedure-related complications) were observed with LAA … Direct oral anticoagulants (specifically apixaban and dabigatran) demonstrate reductions in stroke events … and reductions (apixaban) or similar (dabigatran) rates in bleeding events when compared with warfarin … Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
    November 03, 2011 - o Treatment discontinuation due to adverse effects. … For categorical variables we will abstract the number of events among treatment groups to calculate … percent CI, we will calculate the relative risk and absolute risk difference from the abstracted events … Time course of adverse events most commonly associated with topiramate for migraine prevention. … A systematic review of adverse events in placebo groups of anti-migraine clinical trials.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
    January 01, 2023 - • Acute adverse events (AEs) were significantly fewer with PBI compared with WBI, with no apparent … This highlights the need to investigate outcomes of PBI among patients with adverse risk factors. … These advancements result in improved dose homogeneity that may lower the risk for adverse events. … PBI is associated with fewer acute adverse effects, but the risk of IBR among patients treated with … PBI who have adverse clinical or pathologic features is unclear.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
    April 01, 2013 - cardiovascular events (MACE) and coronary dissection were significantly lower in the overall analysis … There was a paucity of trials available to evaluate adverse events with any of the embolic protection … conventional PCI 25 trials including 5,534 patients Major adverse cardiac events were significantly … events (MACE) and coronary dissection were significantly lower in the overall analysis and the good … There was a paucity of trials available to evaluate adverse events with any of the embolic protection
  10. effectivehealthcare.ahrq.gov/products/osteoporosis-bone-fracture/research-protocol
    May 14, 2010 - events will be analyzed for KQ4. … Outcomes: Any reported harms/adverse events (AEs) that can be directly associated with use of an agent … KQ4 assesses the evidence for adverse effects of treatment. … Events.9 Then, a verbatim account of the AE will be recorded on the form. … Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0.
  11. Obesity (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - Withdrawals due to adverse events were below 10% in all treatment groups. … Withdrawals due to adverse events were below 10% in both treatment groups. … The rates of serious adverse events in the two groups were similar. … Headache, nausea, and dizziness were the most common lorcaserin-related adverse events. U.S. … Common adverse events were headache, back pain, nasopharyngitis, and nausea.
  12. effectivehealthcare.ahrq.gov/products/lung-cancer-nonsurgical-therapies/research
    June 12, 2013 - sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverseevents, and quality of life among our populations of interest. … Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of
  13. effectivehealthcare.ahrq.gov/products/allergy-seasonal/research-protocol
    March 08, 2012 - events. … events resulting from systemic absorption, such as impaired bone growth, reduced height, suppression … events in SAR research. … Additionally, systematic reviews and meta-analyses that specifically assess adverse events associated … events, and results.
  14. effectivehealthcare.ahrq.gov/products/hip-fracture-pain/research-protocol
    December 09, 2009 - For KQ3, all reported adverse events (AE) that are directly or indirectly associated to the intervention … Also, adverse events may occur at any point after the treatment is received (e.g., medication adverseevents outcomes AE related to the pain management intervention Mental status Health-related … For the questions on safety and adverse effects, in addition to the above databases, we will search the … National Library of Medicine's TOXLINE® (1965 to present), and Canada’s Adverse Drug Reaction Database
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
    January 01, 2019 - events, side effects of interventions (any time frame) o Hospitalization comparison:  Hospital-based … infections and other harms o Antibiotics comparisons:  Side effects/adverse events attributable … events related to procedures, including bleeding and catheter infections  Need for second procedures … o N≥30/arm* • Single group studies o Only for adverse events o N>100† • Longitudinal (Exclude: … events, and side effects of colonoscopy (e.g. perforation, bleeding) Modifiers/Subgroups of interest
  16. effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
    April 01, 2020 - in frequency of intervention-related adverse events or withdrawals. … Table 64 in the full report summarizes reported adverse events for each intervention. … No serious intervention-related adverse events leading to death or disability or requiring intensive … Evidence was low or insufficient for other adverse events. … Acupuncture-related adverse events: a systematic review of the Chinese literature.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-muscle-invasive_executive.pdf
    June 01, 2015 - events; withdrawals due to adverse events; and sources of funding. … Although cisplatin is nephrotoxic, renal adverse events were not well reported.28 No study compared … radical cystectomy: adverse events Insufficient There was insufficient evidence from 4 studies of … with grade 3 or 4 hematological adverse events. … Adjuvant chemotherapy vs. no adjuvant chemotherapy: adverse events Insufficient Harms were poorly
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/allergy-seasonal_research-protocol.pdf
    March 08, 2012 - events. … events resulting from systemic absorption, such as impaired bone growth, reduced height, suppression … events in SAR research. … Additionally, systematic reviews and meta-analyses that specifically assess adverse events associated … events, and results.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
    February 01, 2018 - Example binary data for effect size computation Treatment Events in Treatment Group Treatment n … Number-Needed-to-Treat-Related Concepts for Assessing Treatment Efficacy in the Presence of Treatment-Induced AdverseEvents. … Number-Needed-to-Treat-Related Concepts for Assessing Treatment Efficacy in the Presence of Treatment-Induced AdverseEvents.
  20. effectivehealthcare.ahrq.gov/sites/default/files/topic-refinement.ppt
    March 01, 2010 - The adverse events include altered glucose, diabetes mellitus, lymphoid overgrowth, and malignancy. … KQ 6: In patients with CF, how are efficacy, effectiveness, safety, or adverse events impacted by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety, or adverse events of treatment … Key question 6: In patients with CF, how are efficacy, effectiveness, safety, or adverse events impacted … Key question 7: In patients with CF, how do the efficacy, effectiveness, safety, or adverse events of

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