-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_disposition-comments.pdf
November 27, 2012 - This is in contrast to Telaprevir’s
association with dermatological adverse events,
which are unique … We have have made distinctions in our
report regarding the adverse events for each drug. … This false
impression is further reinforced by the consistent
pairing of hematological adverse events … Page 69: "… specific
harms associated with use of these drugs (such as
hematologic adverse events with … boceprevir…" As
noted on pages 46 and 47 of this review, hematologic
adverse events are not specific
-
effectivehealthcare.ahrq.gov/products/cad-women-treatment/research-protocol
January 24, 2011 - treatment and revascularization therapies specifically in women is needed to reduce cardiovascular events … cardiovascular events; MI = myocardial infarction; NSTEMI = non–ST-elevation myocardial infarction; … cardiovascular events: death, nonfatal myocardial infarction, stroke, and repeat revascularization … The safety outcomes will be framed to help identify adverse events, including adverse drug reactions, … cardiovascular events
MI Myocardial infarction
NSTEMI Non–ST-elevation myocardial infarction
PCI
-
effectivehealthcare.ahrq.gov/products/diverticulitis/protocol
September 12, 2019 - events, side effects of interventions (any time frame)
Hospitalization comparison:
Hospital-based … infections and other harms
Antibiotics comparisons:
Side effects/adverse events attributable to … events related to procedures, including bleeding and catheter infections
Need for second procedures … N≥30/arm *
Single group studies
Only for adverse events
N>100 §
Longitudinal ( Exclude: cross-sectional … events, and side effects of colonoscopy (e.g. perforation, bleeding)
Modifiers/Subgroups of interest
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
December 20, 2011 - events: overall adverse events, withdrawals due to adverse events,
and specific adverse events (including … KQ 6 looks as the adverse effects
of these interventions. … events. … Impact of Events Scale - Revised (IES-R). … caused by traumatic
events
-
effectivehealthcare.ahrq.gov/sites/default/files/obesity-horizon-scan-high-impact-1306.pdf
July 01, 2013 - Withdrawals due to adverse events were below
10% in all treatment groups. … Withdrawals due
to adverse events were below 10% in both treatment groups. … The rates of serious adverse events in the two groups were
similar. … Headache, nausea, and dizziness were the most common lorcaserin-related
adverse events. U.S. … Common adverse events were
headache, back pain, nasopharyngitis, and nausea.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
October 01, 2012 - events that should be
followed up. … events
data from different studies,
adverse events reported
generally were consistent with
known … Relation between kidney function,
proteinuria, and adverse outcomes. … Raloxifene was associated with
significantly fewer kidney-related adverse
events compared with placebo … events data from different
studies, adverse events reported generally
were consistent with known potential
-
effectivehealthcare.ahrq.gov/products/crohns-disease/research-protocol
September 01, 2010 - events.13 The first anti-tumor necrosis factor-α (anti-TNF) biologic, infliximab, was approved for Crohn … events. 13
Treatment guidelines and meta-analyses on the management of Crohn’s disease. … events. … events, and patient-reported outcomes. … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-treatment_research-protocol.pdf
September 29, 2011 - treatment and revascularization therapies specifically in women is
needed to reduce cardiovascular events … of treatment listed above comprise optimal medical therapy of CAD to
reduce future cardiovascular events … cardiovascular events; MI = myocardial infarction; NSTEMI = non–ST-elevation myocardial infarction; … cardiovascular events: death,
nonfatal myocardial infarction, stroke, and repeat revascularization … The safety outcomes will be framed to help
identify adverse events, including adverse drug reactions
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
October 01, 2021 - • Adverse effects of the interventions were inadequately reported in many studies. … All studies focused
on benefits of physical activity, with inadequate reporting of adverse events in … activities, and intensity of physical activity; incomplete data
analysis; inadequate reporting of adverse … events; and relatively few trials considered to be
high quality (low risk of bias).
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/improved-cancer-outcomes-protocol_0.pdf
December 01, 2021 - events and survival? … events and survival? … events and
survival? … events
• Chemotherapy /radiation therapy
limiting toxicity
• Post-op complication
• NI-related … events and survival among adults w ith cancer w ho are overw eight or
obese.
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/standardized-library-depression-white-paper.pdf
May 01, 2020 - Relationships between events raise a challenge because relationships are often not directly
asserted … • FHIR resources for additional relevant events: These might include procedures,
encounters, etc … • Temporal aspects for all events: These allow for inferred relationships.
3
Approach … Events of Interest Adverse Events Depression treatment-related adverse events. … Use of a brief, publicly available,
validated measurement tool to capture adverse events is recommended
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/standardized-library-depression-white-paper.pdf
May 01, 2020 - Relationships between events raise a challenge because relationships are often not directly
asserted … • FHIR resources for additional relevant events: These might include procedures,
encounters, etc … • Temporal aspects for all events: These allow for inferred relationships.
3
Approach … Events of Interest Adverse Events Depression treatment-related adverse events. … Use of a brief, publicly available,
validated measurement tool to capture adverse events is recommended
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - PMID: 11252006. http://dx.doi.org/10.1002/sim.650
Rare binary outcomes
• For rare binary events ( … e.g., adverse events), few or zero events may
occur in one or both trial arms.7,8
► In this case the … (e.g., adverse events)
• PL methods:
► Better account for uncertainty in estimating between-study variance … • For rare binary events:
► Avoid methods that use continuity corrections. … ► For studies with zero events in one arm, or studies with sparse binary data
but no zero events,
-
effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
November 22, 2011 - cardiovascular events. … cardiovascular events; however they reached contradictory conclusions. … effects of test-directed treatment (including bleeding events and other adverse events such as gastrointestinal … events and liver toxicity)
Adverse effects of testing per se (including test-related anxiety and adverse … events secondary to venipuncture).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
September 01, 2010 - events.13 The first anti-tumor necrosis factor-α (anti-
TNF) biologic, infliximab, was approved for … events.13
Treatment guidelines and meta-analyses on the management of Crohn’s disease. … events. … events, and patient-reported outcomes. … events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
December 14, 2017 - findings that, in general, low-frequency
of adverse events occur during the treatment and only minor … adverse events are reported post procedure. … (Castro, 2010)
We added the following to the Adverse
Events and Mortality section, after listing … the events for the AIR2 trial: “The
investigators state that all adverse
events were treated with “ … Serious adverse events attributed to BT were
infrequent, and no deaths were reported.”
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/updating-treatments-fecal-incontinence-iii
March 15, 2021 - symptom burden based on the CCFIS from baseline through 36-months post-treatment
Treatment-related adverse … events associated with NASHA/Dx treatment are low and NASHA/Dx demonstrates an excellent safety profile … Dx FI for reducing fecal incontinence episodes is stable for up to 3 years and that the incidence of adverse … events remains low
Reduction of fecal incontinence episodes at 6 months was sustained at continued
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-239-episodic-migraine-comments.pdf
December 29, 2020 - administration and study settings (e.g., home, outpatient,
emergency room, and inpatient), lack of data on adverse … events due to frequent or long-term
intermittent use of medications, and harms associated with newer … Evidence
was insufficient to draw
conclusions about serious adverse
events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy-surveillance.pdf
September 01, 2017 - Adverse effects of intervention(s): withdrawals due to
adverse events, nausea/vomiting, diarrhea, anorexia … Naltrexone
One study 24 (n=128) reported no serious adverse
events, but an increase in sleepiness … Baclofen
There were no serious adverse events related to
baclofen in two studies: one RCT (n=56), 23 … The
majority of serious adverse events in the placebo
group (88%) and the nalmefene group (76%) were … They reported mental slowing, a reduction in verbal
fluency and working memory as adverse events
among
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbi-protocol.pdf
August 09, 2021 - The review will also provide rates of
adverse events of the various PBI modalities necessary for shared … In adult women with early stage breast cancer, what are the comparative effectiveness,
adverse events … How do the effectiveness, adverse events, and cosmetic outcomes of partial breast
irradiation vary by … In adult women with early stage breast cancer, what are the comparative effectiveness,
adverse events … events (KQ1-2)
Rate of adverse events
(noncomparative series of PBI) (KQ 2a)
Financial toxicity (KQ