-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
March 10, 2010 - "Increasing statin dose or potency could potentially increase
frequency of important adverse events … Revised as follows:
For clinical outcomes and serious adverse events, we anticipated that
the available … Information on adverse events was only collected if dichotomous
data were available (number of people … A decline in cellular and physiologic system increases vulnerability to
adverse events of treatment. … Information on adverse events were only collected if dichotomous
data were available (number of people
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
May 16, 2013 - The overall rates of complications/major adverse events
were under 7%.9,10,15,18-20,25. … There is a low level of evidence that adverse events
associated with RFA are relatively uncommon. … Most of the studies did not
report the time of occurrence of the adverse events. … Major adverse events associated with RFA are
relatively uncommon. … of the various
adverse events were not always comparable.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
June 01, 2017 - Secondary
Adverse events, otoscopic exams, audiometry, and tympanometry
Microbiological response … In general, there were few serious adverse events and many other
adverse events. … showed more adverse events in the intervention group. … events, including serious adverse events (not defined), other
adverse events (not defined), and acute … Question 3: What adverse events, surgical complications, and sequelae are associated with
inserting
-
effectivehealthcare.ahrq.gov/products/high-cholestorol-medications/research
September 01, 2009 - intensive lipid-modifying therapy, what are the comparative long-term benefits and rates of serious adverse … events of coadministration of different lipid-modifying agents (i.e., a statin plus another lipid-modifying
-
effectivehealthcare.ahrq.gov/products/osteoporosis/research
December 17, 2007 - Comparative Effectiveness Review (CER) compares the benefits in fracture reduction and the harms from adverse … events (AE) among and within the various classes of treatment for low bone density.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_surveillance.pdf
April 01, 2016 - For reviewing adverse events (KQ 4), per our
standard approach, we include observational studies. … (SOE: Insufficient)
Specific adverse events. … We looked at both withdrawals
that investigators attributed to adverse events
and overall numbers … There
was no difference in cognitive function
between groups.
1
Abbreviations: AE=Adverse Events … (SOE:
Insufficient)
Specific adverse events.
-
effectivehealthcare.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
April 05, 2010 - Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer. … events. … Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
April 06, 2010 - Outcomes include intermediate outcomes, long-term outcomes, safety, adverse
events, mortality, and quality … Adverse events include congestive heart failure,
hypoglycemia, pancreatitis, fractures, and cancer. … events. … Outcomes include intermediate outcomes, long-term outcomes, safety, adverse
events, mortality, and quality … Adverse events include congestive heart failure,
hypoglycemia, pancreatitis, fractures, and cancer.
-
effectivehealthcare.ahrq.gov/products/depression-pregnancy-postpartum/research-protocol
March 29, 2013 - depression in pregnant women include younger age, non-Latino ethnicity, being without a partner, traumatic events … effects or withdrawals due to specific adverse events related to treatment (e.g., hyponatremia, activation … reports
Withdrawals from study and discontinuation of treatment due to adverse events
Adverse events … associated with discontinuation of treatment
Serious adverse events reported
Fetus, Infant, and … events (e.g., withdrawal symptoms [neonatal abstinence symptoms], pulmonary hypertension, respiratory
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
March 29, 2013 - depression in pregnant women include younger age, non-Latino ethnicity, being without a
partner, traumatic events … effects or withdrawals due to specific adverse events related to
treatment (e.g., hyponatremia, activation … reports
• Withdrawals from study and discontinuation of treatment due to adverse events
Source: … events associated with discontinuation of treatment
• Serious adverse events reported
Fetus, Infant … events (e.g., withdrawal symptoms [neonatal abstinence
symptoms], pulmonary hypertension, respiratory
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
October 08, 2014 - events during therapy for the “intent to treat analysis” in order to determine
which patients would … diabetes after transplant
§ Major adverse cardiac events
§ Malignancy
§ Infections
o timing … events:
• Nephrotoxicity
• New onset diabetes
• Major cardiac events
• Neurologic complications … The adverse events and harms reported by any study included to address any
of the questions will be … used to assess harms and adverse events related to therapeutic
monitoring of CNIs and CNI treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
June 01, 2022 - Opioids were associated with increased risk of various adverse events,
including withdrawal due to adverse … There were no serious
adverse events with either TENS or opioids. … Harms and Adverse Events:
a. … events, serious
adverse events, overdose, substance misuse,
substance use disorder related outcomes … Harms and Adverse Events:
Key Question 3. Dosing Strategies:
Key Question 4.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - events is
critically important
The specific adverse events that were selected
for this report, and … The specific adverse events that were selected
for this report, and were graded (implying a
higher … The specific adverse events that were selected
for this report, and were graded (implying a
higher … The
protocol for this review does not include the
outcome “severe adverse events”, similar to
total … adverse events but those reported to be
severe by the individual trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - events is
critically important
The specific adverse events that were selected
for this report, and … The specific adverse events that were selected
for this report, and were graded (implying a
higher … The specific adverse events that were selected
for this report, and were graded (implying a
higher … The
protocol for this review does not include the
outcome “severe adverse events”, similar to
total … adverse events but those reported to be
severe by the individual trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
June 15, 2011 - adverse treatment effects may manifest in less than 1 year. … events, and adherence. … The quality of RCTs and observational
cohort studies reporting adverse events will be evaluated by … events according to: patient demographic and comorbid characteristics (age, gender,
race, baseline … Risk of renal stone events in primary
hyperparathyroidism before and after parathyroid surgery: controlled
-
effectivehealthcare.ahrq.gov/products/nppv-respiratory-failure/research-protocol
April 21, 2011 - Adverse effects of interventions (KQs 1–4):
Rates of:
Aspiration
Secondary infections (including … events outcomes). … The safety outcomes will be framed to help identify adverse events, including aspiration, secondary infections … events; and intermediate, final, and adverse events outcomes. … rates of events, or both.
-
effectivehealthcare.ahrq.gov/products/adhd-heart-disease-adults/research
November 01, 2011 - Food and Drug Administration (FDA) Adverse Event Reporting System data have raised concern that attention-deficit … Results
Cohort members had 81 serious cardiovascular events (3.1/100,000 person-years). … Current ADHD medication users had no increased risk for serious cardiovascular events (adjusted hazard … Conclusions
Although there was no evidence of increased risk of serious cardiovascular events for current
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-key-questions.pdf
January 01, 2019 - Physical examination,
urodynamic studies, MR
Imaging, myelogram, CT scan,
CAT scan, ultrasound
Adverse … cord transection, or other
surgery
Intermediate outcomes:
KQ2-4: Gait
KQ3: Repeat surgery
Adverse … effects of treatment:
Adverse events, postoperative
complications, infection,
unnecessary surgery … pain, gait,
walking difficulty, bowel incontinence, bladder incontinence, scoliosis,
disability, adverse … events, postoperative complications, infection, 30-
day complication rate, repeat surgery, morbidity
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-nerve-block-key-questions.pdf
May 09, 2019 - has
highlighted the increased risk for postoperative morbidity and mortality from opioid-
related adverse … These interventions have the potential to reduce perioperative
opioid use and its associated adverse … stay
Opioid use
Health related quality of life
Patient satisfaction Harms
Complications/Adverse … events of treatment
(readmission, bleeding, etc.) … Complications and/or adverse events of treatment (readmission, bleeding,
etc.)
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
December 15, 2010 - , withdrawal
due to adverse events)? … events
o Serious adverse events (composite outcome)c
o Neurologic adverse events (e.g., neuropathy … /intraventricular,
gastrointestinal, hematuria)
o Withdrawal due to adverse events
o Other reported … important clinical adverse events
• Organ toxicity
o Liver (aspartate aminotransferase [AST], … events (composite outcome—FDA definition of serious adverse events24),
withdrawal due to adverse