-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_disposition-comments.pdf
December 20, 2012 - We agree that
interventions for managing adverse
events may be considered patient-
level interventions … effects” “adverse events”, or “side effects.” … We
have replaced adverse effects with
“adverse events” throughout the
document. … We agree that
interventions for managing adverse
events may be considered patient-
level interventions … We agree that
interventions for managing adverse
events may be considered patient-
level interventions
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-prevention_research-protocol.pdf
November 03, 2011 - o Treatment discontinuation due to adverse effects. … For categorical variables we will abstract the number of events among treatment
groups to calculate … percent CI, we will calculate the
relative risk and absolute risk difference from the abstracted events … Time course of adverse events most commonly
associated with topiramate for migraine prevention. … A systematic review of adverse events in placebo
groups of anti-migraine clinical trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
October 01, 2012 - events that should be
followed up. … events
data from different studies,
adverse events reported
generally were consistent with
known … Relation between kidney function,
proteinuria, and adverse outcomes. … Raloxifene was associated with
significantly fewer kidney-related adverse
events compared with placebo … events data from different
studies, adverse events reported generally
were consistent with known potential
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/adhd-future_research.pdf
May 01, 2012 - However, adverse
events, especially irritability and moodiness, can lead to discontinuation, and use … Few serious adverse events were noted. … Fewer
individuals discontinue psychostimulants and ATX than guanfacine XR due to adverse events. … We have identified key clinical and adverse events outcomes
as reported in the draft review, which is … Among individuals ages 6 years or older with ADHD, what are the adverse events and
noncompliance rates
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-protocol.pdf
July 01, 2023 - scan
patient data for signs of clinical deterioration in order to alert a clinician of a potential adverse … .9-11 One
study found no statistical improvement in the number of rescue events but did find that the … Activation of rapid response system (a process
measure)
• Cardiorespiratory arrest
• Serious adverse … Effectiveness of continuous or intermittent vital signs
monitoring in preventing adverse events on … scan patient data for signs of clinical deterioration in order to alert a clinician of a potential adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/high-cholestorol-medicines-update_research-protocol.pdf
December 31, 2013 - events when compared with statin monotherapy. … The CER will examine surrogate markers
of CHD events including lipid levels and atherosclerosis, as … Ridker PM, Rifai N, Pfeffer MA, et al; Cholesterol and Recurrent Events Investigators. … Primary prevention of acute coronary events with
lovastatin in men and women with average cholesterol … Rosuvastatin to
prevent vascular events in men and women with elevated C-‐reactive
protein.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
January 31, 2013 - cardiovascular events, functional capacity, and quality of life. … What are the significant safety concerns associated with each treatment strategy
(e.g., adverse drug … What are the significant safety concerns associated with each treatment strategy
(e.g., adverse drug … What are the significant safety concerns associated with each treatment strategy
(e.g., adverse drug … The safety outcomes
will be framed to help identify adverse events, including adverse drug reactions
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
January 09, 2020 - In addition to effectiveness, decisionmakers need information on potential adverse risks, and
special … Pain, function, pain relief satisfaction and quality of life,
harms/adverse events (including withdrawal … events
KQ 3: Non-invasive non-pharm Therapy:
Pain, function, pain relief satisfaction, quality of … life and quality of
life, harms, adverse events
None
Timing At the following intervals: < 1 day … events in patients
with migraine.
-
effectivehealthcare.ahrq.gov/sites/default/files/methods-report-web-interactive-presentation-appendix-a.pdf
May 29, 2025 - categories) for
• Cure, improvement, satisfaction (n=117 studies)
• Quality of life (n=84 studies)
• Adverse … events (n=138 studies)
4
An interactive tool
5
Level 1
Evidence Graph
for specific
interventions
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
November 30, 2011 - dosages and durations of treatment according to
various factors.
10
A common (50 to 60 percent) adverse … In addition, psychiatric,
gastrointestinal, dermatological, and hematologic adverse effects underlie … effects of intervention(s)
Harms from antiviral treatment, including withdrawals due to adverse … events, serious
adverse events such as severe neutropenia, psychological adverse events, flu-like … symptoms, and hematological adverse events
Timing and Setting:
No minimum timing and all settings
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - What are the harms, including adverse events,
associated with interventions for management of
postpartum … Also, adverse
events may occur at any point after the intervention is
received.
Figure A. … Few studies of uterine balloon tamponade reported
adverse events, and studies of embolization reported … Harms
reporting was limited to 50 studies and was difficult to
synthesize because diverse adverse events … Adverse events and longer term outcomes
associated with procedures and surgical interventions are
also
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
May 02, 2025 - Nutritional assessment
• Quality of life, using validated scales
• Direct moderate-severe treatment adverse … events (grade 3, 4, 5)
• Direct mild treatment adverse events (grade
1, 2)
• Indirect adverse … :
Any follow-up duration for grade 3-5 or indirect
adverse events and quality of life; minimum of 1 … year
N/A
for grade 1-2 adverse events; minimum of 3 months
for remaining outcomes
Setting … For direct treatment adverse events (AEs) and indirect treatment-related AEs, we will prioritize
using
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - adverse events, flu-like symptoms, rash)
Intermediate outcomes
•! … Found no difference in withdrawals due to adverse events. … No difference in risk of withdrawal due to adverse events. … Found no difference in
withdrawals due to adverse
events. … No difference in risk of
withdrawal due to adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - adverse events, flu-like symptoms, rash)
Intermediate outcomes
•! … Found no difference in withdrawals due to adverse events. … No difference in risk of withdrawal due to adverse events. … Found no difference in
withdrawals due to adverse
events. … No difference in risk of
withdrawal due to adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
January 01, 2008 - the cost of treatment,
the severity of diseases that HSCT is used to treat, and the prevalence of adverse … events associated
with HSCT, a comprehensive review that focuses on both benefits and harms across
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0086_04-01-2009.pdf
January 01, 2009 - any commonly used dietary supplements decrease the
effectiveness of these medications or increase adverse … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_research-protocol.pdf
December 06, 2010 - Many questions remain about the
risks of these agents across a spectrum of adverse events—from relatively … 3: For patients with RA, do drug therapies differ in harms, tolerability, patient
adherence, or adverse … Morbidity, mortality, and other serious adverse events
ii. Tolerability
iii. Adherence
iv. … Other adverse effects
• Timing:
Minimum of 3 months of follow-up
• Settings:
Primary care … Also, adverse events may occur at any point after the treatment is received.
IV. Methods
A.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - Intranasal corticosteroids do not appear
to cause adverse events associated with systemic
absorption … Adverse events may occur
at any point after treatment is received and may impact
quality of life directly … Meta-
analysis was performed for adverse events that investigators
reported as severe or that led to … events are not expected. … events; underrepresentation of populations
of interest, especially children and pregnant women; and
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
January 01, 2019 - events, side effects of interventions (any time frame)
o Hospitalization comparison:
Hospital-based … infections and other harms
o Antibiotics comparisons:
Side effects/adverse events attributable … events related to procedures, including bleeding and catheter
infections
Need for second procedures … o N≥30/arm*
• Single group studies
o Only for adverse events
o N>100†
• Longitudinal (Exclude: … events, and side effects of colonoscopy (e.g. perforation, bleeding)
Modifiers/Subgroups of interest
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-hospitalized-adults-evidence-summary_0.pdf
October 01, 2021 - length of stay, activities of daily
living, discharge disposition, hospital acquired conditions, or adverse … events). … These studies had several
shortcomings, including high risk of bias and poor reporting of adverse events