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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
    March 10, 2010 - "Increasing statin dose or potency could potentially increase frequency of important adverse events … Revised as follows: For clinical outcomes and serious adverse events, we anticipated that the available … Information on adverse events was only collected if dichotomous data were available (number of people … A decline in cellular and physiologic system increases vulnerability to adverse events of treatment. … Information on adverse events were only collected if dichotomous data were available (number of people
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/atrial-fibrillation-ablation_surveillance.pdf
    May 16, 2013 - The overall rates of complications/major adverse events were under 7%.9,10,15,18-20,25. … There is a low level of evidence that adverse events associated with RFA are relatively uncommon. … Most of the studies did not report the time of occurrence of the adverse events. … Major adverse events associated with RFA are relatively uncommon. … of the various adverse events were not always comparable.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
    June 01, 2017 - Secondary Adverse events, otoscopic exams, audiometry, and tympanometry Microbiological response … In general, there were few serious adverse events and many other adverse events. … showed more adverse events in the intervention group. … events, including serious adverse events (not defined), other adverse events (not defined), and acute … Question 3: What adverse events, surgical complications, and sequelae are associated with inserting
  4. effectivehealthcare.ahrq.gov/products/high-cholestorol-medications/research
    September 01, 2009 - intensive lipid-modifying therapy, what are the comparative long-term benefits and rates of serious adverseevents of coadministration of different lipid-modifying agents (i.e., a statin plus another lipid-modifying
  5. effectivehealthcare.ahrq.gov/products/osteoporosis/research
    December 17, 2007 - Comparative Effectiveness Review (CER) compares the benefits in fracture reduction and the harms from adverseevents (AE) among and within the various classes of treatment for low bone density.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_surveillance.pdf
    April 01, 2016 - For reviewing adverse events (KQ 4), per our standard approach, we include observational studies. … (SOE: Insufficient) Specific adverse events. … We looked at both withdrawals that investigators attributed to adverse events and overall numbers … There was no difference in cognitive function between groups. 1 Abbreviations: AE=Adverse Events … (SOE: Insufficient) Specific adverse events.
  7. effectivehealthcare.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
    April 05, 2010 - Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer. … events. … Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/type-2-diabetes-medications-update_research-protocol.pdf
    April 06, 2010 - Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer. … events. … Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … Adverse events include congestive heart failure, hypoglycemia, pancreatitis, fractures, and cancer.
  9. effectivehealthcare.ahrq.gov/products/depression-pregnancy-postpartum/research-protocol
    March 29, 2013 - depression in pregnant women include younger age, non-Latino ethnicity, being without a partner, traumatic events … effects or withdrawals due to specific adverse events related to treatment (e.g., hyponatremia, activation … reports Withdrawals from study and discontinuation of treatment due to adverse events Adverse events … associated with discontinuation of treatment Serious adverse events reported Fetus, Infant, and … events (e.g., withdrawal symptoms [neonatal abstinence symptoms], pulmonary hypertension, respiratory
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
    March 29, 2013 - depression in pregnant women include younger age, non-Latino ethnicity, being without a partner, traumatic events … effects or withdrawals due to specific adverse events related to treatment (e.g., hyponatremia, activation … reports • Withdrawals from study and discontinuation of treatment due to adverse events Source: … events associated with discontinuation of treatment • Serious adverse events reported Fetus, Infant … events (e.g., withdrawal symptoms [neonatal abstinence symptoms], pulmonary hypertension, respiratory
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/calcineurin-inhibitor_research-protocol.pdf
    October 08, 2014 - events during therapy for the “intent to treat analysis” in order to determine which patients would … diabetes after transplant § Major adverse cardiac events § Malignancy § Infections o timing … events: • Nephrotoxicity • New onset diabetes • Major cardiac events • Neurologic complications … The adverse events and harms reported by any study included to address any of the questions will be … used to assess harms and adverse events related to therapeutic monitoring of CNIs and CNI treatment
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
    June 01, 2022 - Opioids were associated with increased risk of various adverse events, including withdrawal due to adverse … There were no serious adverse events with either TENS or opioids. … Harms and Adverse Events: a. … events, serious adverse events, overdose, substance misuse, substance use disorder related outcomes … Harms and Adverse Events: Key Question 3. Dosing Strategies: Key Question 4.
  13. effectivehealthcare.ahrq.gov/sites/default/files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
    September 03, 2019 - events is critically important The specific adverse events that were selected for this report, and … The specific adverse events that were selected for this report, and were graded (implying a higher … The specific adverse events that were selected for this report, and were graded (implying a higher … The protocol for this review does not include the outcome “severe adverse events”, similar to total … adverse events but those reported to be severe by the individual trials.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
    September 03, 2019 - events is critically important The specific adverse events that were selected for this report, and … The specific adverse events that were selected for this report, and were graded (implying a higher … The specific adverse events that were selected for this report, and were graded (implying a higher … The protocol for this review does not include the outcome “severe adverse events”, similar to total … adverse events but those reported to be severe by the individual trials.
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-prevention_research-protocol.pdf
    June 15, 2011 - adverse treatment effects may manifest in less than 1 year. … events, and adherence. … The quality of RCTs and observational cohort studies reporting adverse events will be evaluated by … events according to: patient demographic and comorbid characteristics (age, gender, race, baseline … Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled
  16. effectivehealthcare.ahrq.gov/products/nppv-respiratory-failure/research-protocol
    April 21, 2011 - Adverse effects of interventions (KQs 1–4): Rates of: Aspiration Secondary infections (including … events outcomes). … The safety outcomes will be framed to help identify adverse events, including aspiration, secondary infections … events; and intermediate, final, and adverse events outcomes. … rates of events, or both.
  17. effectivehealthcare.ahrq.gov/products/adhd-heart-disease-adults/research
    November 01, 2011 - Food and Drug Administration (FDA) Adverse Event Reporting System data have raised concern that attention-deficit … Results Cohort members had 81 serious cardiovascular events (3.1/100,000 person-years). … Current ADHD medication users had no increased risk for serious cardiovascular events (adjusted hazard … Conclusions Although there was no evidence of increased risk of serious cardiovascular events for current
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-key-questions.pdf
    January 01, 2019 - Physical examination, urodynamic studies, MR Imaging, myelogram, CT scan, CAT scan, ultrasound Adverse … cord transection, or other surgery Intermediate outcomes: KQ2-4: Gait KQ3: Repeat surgery Adverse … effects of treatment: Adverse events, postoperative complications, infection, unnecessary surgery … pain, gait, walking difficulty, bowel incontinence, bladder incontinence, scoliosis, disability, adverseevents, postoperative complications, infection, 30- day complication rate, repeat surgery, morbidity
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-nerve-block-key-questions.pdf
    May 09, 2019 - has highlighted the increased risk for postoperative morbidity and mortality from opioid- related adverse … These interventions have the potential to reduce perioperative opioid use and its associated adverse … stay  Opioid use  Health related quality of life  Patient satisfaction Harms Complications/Adverseevents of treatment (readmission, bleeding, etc.) … Complications and/or adverse events of treatment (readmission, bleeding, etc.)
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
    December 15, 2010 - , withdrawal due to adverse events)? … events o Serious adverse events (composite outcome)c o Neurologic adverse events (e.g., neuropathy … /intraventricular, gastrointestinal, hematuria) o Withdrawal due to adverse events o Other reported … important clinical adverse events • Organ toxicity o Liver (aspartate aminotransferase [AST], … events (composite outcome—FDA definition of serious adverse events24), withdrawal due to adverse

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