-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
July 01, 2012 - develop estimates.4
Time Lag
The time lag between genetic testing and clinically important events … between genotype and metabolism of SSRIs (phenotype), metabolism and SSRI
efficacy, and metabolism and adverse … 3c: How well does CYP450 testing predict adverse drug reactions? … genetic tests are generally characterized by a delayed time between testing and
clinically important events
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0855-170515.pdf
April 28, 2017 - Diabetes diagnosis
Health-related quality of life
Functionality
Death from any cause
Adverse … events
Costs
Intermediate outcomes:
Glucose levels/glycemic control
Medication adherence … Long-term outcomes:
Health-related quality of life
Functionality
Death from any cause
Adverse … events
Costs
4
Methods
To assess topic nomination #0672 mHealth for Diabetes for priority
-
effectivehealthcare.ahrq.gov/sites/default/files/tnd-0855-170515.pdf
April 28, 2017 - Diabetes diagnosis
Health-related quality of life
Functionality
Death from any cause
Adverse … events
Costs
Intermediate outcomes:
Glucose levels/glycemic control
Medication adherence … Long-term outcomes:
Health-related quality of life
Functionality
Death from any cause
Adverse … events
Costs
4
Methods
To assess topic nomination #0672 mHealth for Diabetes for priority
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
December 01, 2010 - ”9 This is especially true for outcomes that RCTs may not be adequately designed
to address (e.g., adverse … This is a retrospective
study that collects data on events that have already occurred. … This is a retrospective study that collects data on events that
have already occurred. … Case reports can be valuable for assessing rare but severe adverse
events. … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/inguinal-hernia_disposition-comments.pdf
August 17, 2012 - makes a distinction
between what is commonly known and what was systematically
reviewed in terms of adverse … events/harms. … We added three paragraphs discussing various outcomes:
short-term recovery outcomes, adverse events
-
effectivehealthcare.ahrq.gov/products/advanced-care-decision-aids/research-protocol
December 10, 2013 - Were harms or adverse effects collected in the studies; what were they?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
December 01, 2011 - Both
surgical and radiation treatments result in
significant short- and long-term adverse events,
including … In this way, the considerable adverse effects of treatment are
at best avoided, and at least deferred … patient-centered outcomes,
including mortality and disease-free survival, psychometric
measurements, adverse … events, resource utilization, and
costs.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemophilia-dental-rapid-response.pdf
July 01, 2024 - events
• Success of hemophilia treatment
Studies were excluded if they did
not report any of the … damage, alloantibody (inhibitor)
development, infection, cardiovascular event, quality of life, serious adverse … events, and
success of hemophilia treatment
For each included SR, we extracted the date ranges of … dosing every 12 hours in hemophilia A
and 24 hours in hemophilia B”
“The treatment of
inhibitor adverse … events is based on
immune tolerance
induction (ITI) that
will prevent active
bleeding during
surgery
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
January 01, 2013 - Intermediate outcomes
(depicted with round-edge box)
[insert outcome]
[insert outcome]
Adverse … [Insert]
Adverse effects of intervention(s)
1. … Also, adverse
events may occur at any point after the treatment is received. … [Insert]
Adverse effects of intervention(s)
1. … KQ5: How do the efficacy, effectiveness, safety or adverse effects of treatment with DMARDs differ between
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/behavior-change_research.pdf
August 01, 2015 - control group are often included in EPC reviews of medical
interventions in order to assess rare adverse … events. … RCTs are often too small to detect very rare
events, and subjects who are more susceptible to adverse … events due to age or pre-existing
medical conditions are usually excluded from RCTs. … hepatitis C treatment, interventions were grouped by intervention target-policy,
regimen, patient, adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/deliberative-methods-demonstration-executive-131125.pdf
November 01, 2013 - In other instances, participants cited and supported
rules to prevent adverse effects on the public’
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse_disposition-comments.pdf
July 10, 2012 - compared the number
across groups one wonders if they would be significant even though
those few events … effects, I believe one tends to use lower
quality data when looking for adverse effects (eg not intent … “While trial data are limited regarding adverse
effects of screening and behavioral
interventions for … I note that there are no clearly identified adverse effects of
screening. … “While trial data are limited regarding adverse
effects of screening and behavioral
interventions for
-
effectivehealthcare.ahrq.gov/products/healthcare-infections/research-protocol
August 25, 2014 - guidelines, white papers or position statements, regulatory or safety profiles of interventions, reports of adverse … events, descriptions and evaluations of emerging disinfection technologies and monitoring strategies
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/telehealth-covid-19-disposition-comments.pdf
January 03, 2023 - Three studies reported adverse events rates among pregnant women
individuals or those seeking prenatal
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear-surveillance-140925.pdf
February 01, 2014 - • Key question # 5: What are the associated risks, adverse effects, and potential harms of
nonoperative … No Signal
Key question #5
Adverse events or potential harms associated with operative and nonoperative … No Signal
Key question #5
Adverse events or potential harms associated with operative and nonoperative … Key question 5: What are the associated risks, adverse effects, and potential harms of nonoperative and … Key Question 5: What are the associated risks, adverse effects, and potential harms of non-operative
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
September 21, 2012 - Predicting beneficial
38
Developing an Observational CER Protocol: A User’s Guide
and adverse responses … prediction model is by Dorresteijn
et al., who predicted the effect of rosuvastatin on
cardiovascular events
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-216-telehealth-disposition-comments.pdf
April 24, 2019 - By far the
majority of studies made no mention of harms or
adverse events. … potential
harms makes it diff icult to w eigh the benefits of
telehealth consultations against potential adverse … events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
April 01, 2012 - setting
(Biological factors
Preferences/values)
Harms to testing/
screening
Harms
Side effects
Adverse … events
BB
CC
Population Interventions
Medication
Diet
Exercise
Behavioral
Other
Intermediate … For example, while there may be randomized
controlled trials of screening, the question about the adverse … What is the
comparative
effectiveness of
these medications
on cardiovascular
and cerebrovascular
events
-
effectivehealthcare.ahrq.gov/products/venous-ulcers-treatment/research-protocol
March 05, 2012 - ); amoxicillin/clavulanate; dicloxacillin
Inexpensive
Usually require multiple doses/day; major adverse … events include rash, intolerance, allergy
MRSA
Clindamycin
Also can treat anaerobes; allergy is … anatomical locations
Death
Quality of life (general, disease-specific)
Mortality
Functional status
Adverse … events
For topical antibiotics contained in dressings: hypersensitivity, contact dermatitis, sensitization
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - measures or other surrogate variables)
Each major harm (ranging from rare, serious, or life-threatening adverse … events to common but bothersome effects)
For both benefits and harms:
Focus on the outcomes most relevant … or other surrogate variables) and each major harm (ranging from rare, serious, or life-threatening adverse … events to common but bothersome effects).