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Showing results for "adverse events".
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1301. Disposition of Comments Report for Comparative Effectiveness Review 128 Oral Mechanical Bowel Preparation for Colorectal Surgery (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
      April 30, 2014 - referring to complications that possibly could be avoided by OMBP whereas by "harms" you are referring to adverse … events that could be directly attributed to the prep (and not a failure of its efficacy). … anastomotic leak, abscess and peritonitis, because it was not clear in the reviewed studies whether events … Often RCTs do not explore all outcomes of interest, particularly adverse events.

1302. Psychosocial and Pharmacologic Interventions for Disruptive Behavior Disorder | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/disruptive-behavior-disorder/research-protocol
      July 01, 2014 - We added a separate Key Question for harms and adverse effects associated with interventions. … For Key Question 5, we will include studies that report harms (i.e., adverse effects) for an intervention … For Key Question 5, we will include adverse events and harms data (for interventions identified in Key … Potential adverse effects / harms of pharmacologic interventions include: Metabolic effects: weight … gain, hyperglycemia and diabetes, hyperlipidemia Extrapyramidal adverse effects: parkinsonism, acute

1303. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
      January 28, 2016 - interpretation; 3) accuracy of diagnostic methods in select subsegments of the population; and 4) adverse … This is the inverse of the KQ4, the adverse effects of testing. … endoscopy and duodenal biopsy is beyond the scope of this small review, we have added a brief summary of adverse … events in the general population.

1304. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_disposition-comments.pdf
      August 01, 2012 - -There is indirect evidence to suggest that potential harms of monitoring include adverse effects from … We agree that chronic NSAID use and certain other drugs can have adverse renal effects, and that other … Page 3 please provide reference for CKD and frailty, as references are provided for all other adverse … The risk of cardiovascular events is higher in Hispanic versus non-Hispanic white adults with CKD. … Essentially, the risk of adverse cardiovascular events increases in proportion to the level of albuminuria

1305. Outcome Definition and Measurement in Observational Comparative Effectiveness Research
      effectivehealthcare.ahrq.gov/sites/default/files/outcome-definition-and-measurement-chapter-6.pptx
      January 01, 2013 - A composite end point is often used when the individual events included in the score are rare and/or … composite measures are used as compared with individual outcomes, since by grouping numerous types of events … the patient’s functioning), and the interventions being evaluated (including both their positive and adverse … This validation is particularly important for medical events identified in administrative claims databases

1306. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
      October 30, 2019 - Newly identified events in the RE-LY trial. … be included (number needed to treat to achieve a benefit or number needed to harm to achieve an adverse … Fatal GI bleeds were as follows: rivaroxaban 0.01 events per 100 patient years vs. … warfarin: 0.04 events per 100 patient years; p=0.15. … Transfusion ≥4 U were as follows: rivaroxaban 0.47 events per 100 patient years vs.

1307. Development of the RTI Item Bank on Risk of Bias and Precision of Observational Studies (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rti-item-bank-bias-precision_research.pdf
      September 01, 2011 - events described? … events that may be a consequence of the intervention/exposu re been reported? … Events. … Each adverse event of interest should be specified for abstractors. … Are any important harms or adverse events that may be a consequence of the intervention/exposure missing

1308. Arthritis-Knee-Physical-Therapy Executive (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-knee-physical-therapy_executive.pdf
      November 01, 2012 - events were uncommon and varied across interventions. … Adverse events rates did not differ with statistical significance among treatment groups. … Adverse events were not severe enough to deter participants from continuing treatment. … – Adverse events were uncommon, varied across interventions, and included skin irritation with brace … Adverse events were not severe enough to deter participants from continuing treatment.

1309. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/decide16final-mortality-risk-in-copd-pts-using-theophylline.pdf
      December 01, 2009 - Patients were followed for events from April 1, 2003 to September 30, 2005. … Importantly, in several cases theophylline was associated with an increased risk of events; however, … measure medication adherence, and therefore do not know if the observed association is a result of adverse … An overriding concern is that the increased risk of events with theophylline may be a result of disease … It may simply represent an underestimate of events.

1310. Outcomes in COPD patients treated with theophylline (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-management_research.pdf
      December 01, 2009 - Patients were followed for events from April 1, 2003 to September 30, 2005. … Importantly, in several cases theophylline was associated with an increased risk of events; however, … measure medication adherence, and therefore do not know if the observed association is a result of adverse … An overriding concern is that the increased risk of events with theophylline may be a result of disease … It may simply represent an underestimate of events.

1311. Comparative Effectiveness of Screening for Methicillin-Resistant Staphylococcus aureus (MRSA) | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/mrsa-screening-2010/research-protocol
      June 02, 2011 - eradicate/decolonize)—when compared to no screening—on MRSA transmission as measured by new acquisition events … Adverse events: adverse effects of screening and treatment, including allergic reactions, nonallergic … Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus

1312. Mrsa-Screening-2010 Research-Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
      January 01, 2010 - eradicate/decolonize)—when compared to no screening—on MRSA transmission as measured by new acquisition events … O Adverse events: adverse effects of screening and treatment, including allergic reactions, nonallergic … Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus

1313. Defining an Optimal Format for Presenting Research Needs (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-future-presentation-format_research.pdf
      January 01, 2019 - and additional outcomes beyond monetary units (quality adjusted life expectancy, life expectancy, events … Lancet 20671013 Effect of calcium supplements on risk of myocardial infarction and cardiovascular events … meta-analysis 2008 BMJ 16679330 Systematic review and meta-analysis of ethnic differences in risks of adverse … glaucoma 1989 Graefes Arch Clin Exp Ophthalmol 2792592 Statistical uncertainty in the no-observed-adverse-effect … sensitivity analysis 1994 J Toxicol Environ Health 8187733 Statistical issues on the no-observed-adverse-effect

1314. Evidence-based Practice Center Systematic Review Protocol (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment_research-protocol.pdf
      September 13, 2012 - duplex testing Treatment options See Figures 2–4 for possible interventions and comparisons Adverse … amoxicillin/clavulanate; dicloxacillin Inexpensive Usually require multiple doses/day; major adverse … events include rash, intolerance, allergy MRSA Clindamycin Also can treat anaerobes; allergy is … September 13, 2012 – Quality of life (general, disease-specific) – Mortality – Functional status o Adverse … events – For topical antibiotics contained in dressings: hypersensitivity, contact dermatitis, sensitization

1315. Cervical Degenerative Disease Treatment (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cervical-degenerative-protocol.pdf
      January 12, 2022 - dysphagia scales, return to work) • Fusion rate, reoperation rate • Harms (e.g., withdrawals due to adverse … events, serious adverse events, new symptomatic adjacent segment disease, postoperative infection … This may be based on sample size sufficiency and number of events.

1316. Masks for Prevention of COVID-19 in Community and Healthcare Settings (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-review-masks-prevention-covid-version-1.pdf
      December 01, 2021 - When reported, the most common adverse events were discomfort, breathing difficulties, and skin events … but one trial found no difference between a P2 (N95 equivalent) respirator versus surgical mask in adverse … events in persons in the community.27 One trial reported no differences in harms between a surgical … were loss to followup Yes Yes Yes Good Chughtai A, 201616 Yes Unclear Unclear No No Yes For adverse

1317. Patient and Provider Level Strategies to Address Racial/Ethnic Disparities in Health and Healthcare (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/related_files/tech-brief-patient-provider-strategies-protocol-final.pdf
      May 18, 2022 - What are the reported unintended consequences, harms, or adverse events of the strategies used in studies

1318. Medicare-Medication-Use Research (pdf file)
      effectivehealthcare.ahrq.gov/sites/default/files/pdf/medicare-medication-use_research.pdf
      April 01, 2014 - drug interactions.8,9 Multiple medications and use of psychotropic drugs increases the possibility of adverse … drug events.10, 11 Expenditures for medication coverage under Medicare Part D are substantial. … Ad- verse drug events in ambulatory care. New Engl J Med 2003;348:1556-64. 11. … Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive

1319. Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions — An Update to the 2009 Report | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/breast-biopsy-update/research-protocol
      September 20, 2013 - biopsy may result in KQ 1 outcomes such as diagnosis of breast abnormalities, KQ 2 outcomes such as adverse … events, and KQ 3 outcomes such as patient-relevant outcomes. … reporting (separately for each outcome of interest), number of enrolled patients, and numbers of observed events … assessment or visual analog scale or quality of life).de. or satisf$ or QOL or preference$) 19 Adverse … events 12 and ((ae or co).fs. or cross infection or drainage or surgical wound infection).de.) 20

1320. Interventions for Adults With Serious Mental Illness Who Are Involved With the Criminal Justice System | Effective Health Care (EHC) Program
      effectivehealthcare.ahrq.gov/products/mental-illness-adults-prisons/research-protocol
      September 13, 2012 - CTI was designed to prevent homelessness and other adverse outcomes in people with mental illness following … Independent functioning (including employment, housing, social integration) Quality of life Adverse … events including, but not limited to, medication side effects Criminal justice outcomes: Time in … events. … For analysis of rare events (rates <1 percent), we will use either the Peto or Mantel-Haenszel odds ratios