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effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_executive.pdf
January 01, 2011 - on harms.23,26,35,40-43 Specifically, three studies reported no
adverse events associated with iron … Only the Japanese trial specifically monitored
the adverse events associated with study medication; … events associated with iron therapy during the
study periods … Insufficient • Only 1 RCT explicitly monitored the adverse events:
– There were a total of three … events secondary to venipuncture,
effects of iron overload with iron treatments, and cardiovascular
-
effectivehealthcare.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - events caused by the
persistent dopamine receptor blockade by FGAs. … events associated with an antipsychotic are
likely to be consistent regardless of the indication for … ) or for having a
pathologically prolonged QT interval (14 studies, 2425
patients; events in 19 of … Exclusion of patients
with comorbidities, a history of various adverse events,
and/or less-than-moderate … Recognizing and
monitoring adverse events of second-generation antipsychotics
in children and adolescents
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_clinician.pdf
February 01, 2016 - a systematic review evaluating the evidence regarding the efficacy, comparative effectiveness, and adverse … events, coexisting symptoms, and availability of
treatments. … Adult Dosing Mechanism of Action Common Adverse Effects Contraindications
Acamprosate Oral: 666 mg ( … causing accumulation of
acetaldehyde during alcohol consumption,
which, in turn, produces various adverse … Clinicians are advised to refer to the prescribing
information sheet for additional information on adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
July 26, 2012 - protocols for scheduled
imaging, eligible trials did not report results for
imaging of symptomatic stone events … These were rare events
without sufficient evidence to suggest that risk
of death was associated with … events, and predefined
adverse events including effects on comorbid
conditions in all randomized participants … Although one could
argue that symptomatic stone events comprise a more
reproducible, easily countable … not
documented radiographically, may not actually reflect a stone
event at all, 2) multiple stone events
-
effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
March 21, 2016 - (pg. 35)
Public Reviewer 3:
Fred Kurtz,
Medtronic
General
comments
Adverse Events Associated … While your review is comprehensive, most sacral nerve
stimulation reported adverse events are resolved … Published
adverse events and Medtronic’s FDA labeling for the
InterStim device may further inform the … TEP 5
Results Adverse Events are addressed in the text but perhaps an
additional column could be … Same as above for nonsurgical tables
TEP 7
Results The adverse events section was clearly presented
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment_research-protocol.pdf
February 10, 2010 - billion.5
The aim of asthma management is to achieve and maintain control of the disease with as few
adverse … Question 3
What is the nature and frequency of serious adverse effects of treatment with breathing … Events:
• Increased asthma symptoms or acute asthma exacerbations
• Adverse reactions to therapies … The
figure also depicts the possibility of adverse events occurring at any time after treatment
begins … events
(KQ 1)
Use of breathing
exercise or retraining
(KQ 2)
http://www.effectivehealthcare.ahrq.gov
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-update_executive.pdf
August 01, 2016 - , medication
use, and adverse events. … Procedural adverse events were rare and no
medication-related adverse events were reported. … Clinically important adverse events related to PTRAS
are rare; however, studies generally failed to … report
medication-related adverse events. … Data on adverse events were, overall, sparse, particularly
for medical therapy.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
January 01, 2011 - events, such as increased
cardiovascular morbidity and mortality.
12,14,15
For this reason, accurate … What are the adverse effects or harms associated with testing using newer and/or older
markers of iron … What are the adverse effects or harms associated with the treatments guided by tests of
iron status … , adverse events secondary to venipuncture, effects of iron overload with
iron treatments, cardiovascular … events
related to lab
testing
Adverse events
related to
management
strategies
KQ1
KQ
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
November 01, 2017 - Although six
studies reported low rates (0 to 1.2%) of death or serious
adverse events among patients … to treatment for opioid use disorder and risk of
future overdose episodes, in addition to serious adverse … events. … might
be associated with a low rate of serious harms, but patients
were probably at low risk for such events … Adverse events after
naloxone treatment of episodes of suspected acute opioid
overdose.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/arthritis-knee-physical-therapy_research-protocol.pdf
April 01, 2010 - events
Questions 1–3:
• Timing
o At the end of the treatment
o Short-term outcomes (2–6 weeks … We define harms as a totality of all possible adverse consequences of an intervention.34 We
will analyze … For
categorical variables we will abstract a number of events among treatment groups to calculate
rates … We will calculate differences in relative risk and absolute risk from the abstracted events by
using … The number of avoided or excess events (respectively) per population of 1000 is the
difference between
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
September 22, 2014 - drug events related to antibiotics. … Adverse!effects!
of!the!strategy! … confounding factors; and whether the duration of
follow-up was reasonable to capture investigated events … events)
KQ3: Other clinical
outcomes (health care
utilization,
hospitalization, patient
satisfaction … events)
KQ4: Other clinical outcomes
(health care utilization, patient
satisfaction)
KQ 5: Intermediate
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_executive.pdf
September 01, 2011 - Of these, at least
three maternal deaths and three cardiovascular adverse
events were clearly reported … However, given the small number of
events and limited sample size (n=42), the RCT was
underpowered and … events—the
rarer the adverse event, the stronger is the effect size,
and the magnitude of effect size … is an important criterion
that increases our confidence in an estimate.9 However,
adverse events such … events in the
absence of terbutaline therapy due to other reasons.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-adolescents_executive.pdf
August 01, 2012 - consequences of an intervention,
including adverse events (Figure A).14
Key Questions
We have synthesized … events in ASD without being limited to a specific age
range. … events be listed for a drug, rather than just
those for a particular indication. … events may be associated with
medication use in adolescence. … The effects of a rotating
classroom schedule on classroom crisis events in a school for
autism.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-atrial-fibrillation_research-protocol.pdf
January 30, 2012 - review, as well as demographic and
other data needed for determining outcomes (intermediate, final, and adverse … events outcomes). … The safety outcomes will be framed to help
identify adverse events, including those from drug therapies … study design; patient
characteristics; clinical settings; interventions; and intermediate, final, and adverse … , intervention group rates of events, or both.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
December 09, 2009 - events, or adherence? … Adverse effects of interest include but are not limited
to: amnesia, memory loss, headaches, post-operative … : ECT, rTMS, VNS, demonstrated effective psychotherapy
• Outcomes for each question
• Safety
• Adverse … Events
• Adherence
• Timing: Acute phase and continuation phase treatments
• Settings: Mental … KQ4 focuses on safety issues (adverse effects, adherence) with
each of the interventions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
September 01, 2011 - Specifically, the reported adverse event
experience with TMS is now very well established in the two … events observed in TMS
George, et al, (2010) was included during the
update search phase post submission … (2000) The effects of
electroconvulsive therapy in memory of autobiographical and public
events. … events, and therefore lacks the toxicities of more
complex antidepressant pharmacotherapies or the … events responded better to the form of CBT tested than
to any drug intervention.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/trauma-child-interventions_research-protocol.pdf
March 26, 2012 - with a physical illness, 11%; serious accident, 11.6%; natural disaster, 11.1%; fire,
5.9%).1 The Adverse … of childhood trauma
exposure in a large adult population.4 In this population, 65 percent recalled adverse … The criteria for DTD include exposure to
multiple or prolonged adverse events and experiences of affective … Traumatic events and posttraumatic stress in
childhood. … household dysfunction, and the risk
of attempted suicide throughout the life span: findings from the Adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
January 01, 2014 - What are the adverse effects associated with each diagnostic test (including pain,
infection at the … events: immediate
• Settings:
o Primary care (outpatient) or acute care setting, preferentially … events (including adverse patient experiences such as pain or
infection at the aspiration site, effects … events will be included
for key question 2, in anticipation that few studies will address the question … of adverse
outcomes or patient satisfaction with diagnostic procedures.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment-update_research-protocol.pdf
December 31, 2017 - are more effective for victims of particular types of
trauma or to determine comparative risks of adverse … KQ 4: What adverse events (AEs) are associated with treatments for adults diagnosed with
PTSD? … AE = adverse events; CBT = cognitive behavioral therapy; DSM = Diagnostic and Statistical Manual; EFT … Impact of Events Scale - Revised (IES-R). … caused by traumatic
events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
January 01, 2012 - care or other interventions without SMBP in its
effect on relevant clinical outcomes (cardiovascular
events … , mortality, patient satisfaction, quality of
life, and adverse events related to antihypertensive … Note: AE = adverse event; BP = blood pressure; CVD = cardiovascular disease; KQ = Key Question; LVH = … ,
mortality, patient satisfaction, quality of life, and
adverse events related to antihypertensive … One quality C trial found no
difference in adverse drug reactions across four groups with different