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effectivehealthcare.ahrq.gov/sites/default/files/related_files/COVID-19-pharmaceutical-treatments.pdf
December 23, 2023 - Adverse Events Associated with COVID-19 Pharmaceutical Treatments
Evidence-based Practice Center … Rapid Review Protocol
Project Title: Adverse Events Associated with COVID-19 Pharmaceutical
Treatments … of adverse events
associated with the interventions, regardless of medical indication. … events
Common Terminology Criteria for Adverse Events (CTCAE) severity
category3
CTCAE event … Common Terminology Criteria for
Adverse Events (CTCAE) Version 5. November 27, 2017.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/COVID-19-pharmaceutical-treatments-rapid-review.pdf
March 01, 2024 - Events levels in reporting
adverse events. … Adverse Events More Than 45 Days
One RCT that reported at 14 days also reported serious adverse events … adverse
events. … adverse
events;55 risk of bias for adverse events collection and reporting was low. … Events 45 Days or Less
Adverse Events More Than 45 Days
Antivirals: Remdesivir
Adverse Events 45
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effectivehealthcare.ahrq.gov/products/depression-harms/research
March 28, 2019 - Purpose of Review
To assess adverse events of antidepressants in the treatment of major depressive … Duloxetine most likely increases the risk of falls over longer treatment (<24 weeks)
Adverse events … To assess selected adverse events of antidepressants in the treatment of major depressive disorder (MDD … Vortioxetine had fewer adverse events than with duloxetine (high SOE, NNT 6). … events compared with placebo, while adverse events were statistically similar to placebo with SSRIs
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effectivehealthcare.ahrq.gov/products/safety-vaccines/research
May 25, 2021 - Signals from the prior report remain unchanged for adverse events that include anaphylaxis in adults … There remains insufficient evidence to draw conclusions about some rare potential adverse events. … The systematic review was supported by a Technical Expert Panel that identified key adverse events of … We documented observed rates and assessed the relative risks for key adverse events. … A large body of evidence is available to evaluate adverse events following vaccination.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cer-215-depression-older-adults-executive-summary.pdf
March 01, 2019 - adverse events of
antidepressants. … Insufficient evidence:
mortality, serious adverse
events, withdrawals due to
adverse events
SSRI … placebo (RCT)
Adverse events
Similar with bupropion XR
(++)23
Serious adverse events
Similar with … placebo (RCT)
Adverse events
Similar with vortioxetine
(+++)25
Serious adverse events
Similar with … events and
comparative adverse events of antidepressants
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effectivehealthcare.ahrq.gov/products/treatments-acute-pain/research
December 29, 2020 - Opioids are probably associated with increased risk of short-term adverse events versus nonopioid pharmacologic … therapy for acute pain, including any adverse event, study withdrawal due to adverse events, nausea, … dizziness, and somnolence, but serious adverse events are uncommon in randomized trials. … Opioids were associated with increased risk of short-term adverse events versus NSAIDs or acetaminophen … Serious adverse events were uncommon for all interventions, but studies were not designed to assess risk
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effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-vaccines-update-evidence-summary.pdf
May 01, 2021 - There continues to be no evidence of
increased risk of adverse events for vaccines currently recommended … • There remains insufficient evidence to draw conclusions about some rare potential
adverse events … events
Red circle indicates evidence of risk of specific adverse events
White box indicates insufficient … events
Red circle indicates evidence of risk of specific adverse events
White box indicates insufficient … events
Red circle indicates evidence of risk of specific adverse events
White box indicates insufficient
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effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/research
April 16, 2020 - Small to moderate, dose-dependent increases in withdrawal due to adverse events were found with SNRIs … Withdrawal from study due to adverse events was significantly increased with nonopioid drugs, with the … Large increases in risk of adverse events were seen with pregabalin (blurred vision, cognitive effects … Dose viii reductions reduced the risk of some adverse events with SNRI antidepressants. … Increased incidence of drug class–specific adverse events led to withdrawal from treatment in some patients
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effectivehealthcare.ahrq.gov/products/COVID-19-pharmaceutical-treatments/research
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effectivehealthcare.ahrq.gov/products/safety-vaccines/protocol
April 06, 2020 - Also, what are the risks of specific adverse events, the frequency of events, and the certainty of the … Also important to stakeholders is the severity of the adverse events, even when events are likely to … The current CTCAE system (version 5) differentiates 837 adverse events within 26 adverse event domains … The reporting appraisal will assess whether adverse events, including serious adverse events, were defined … for the presence or absence of specific adverse events.
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effectivehealthcare.ahrq.gov/products/hip-fracture-pain/clinician
May 17, 2011 - events of pain management interventions used for elderly patients with hip fracture. … events. … [evidence insufficient]
Adverse Events
Overall, adverse event rates were similar in both treated … Serious adverse events such as myocardial infarction, stroke, and renal failure were either rarely reported … There is limited evidence about the benefits and adverse events of pain-control interventions when they
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surveillance-report-1-treatments-for-acute-pain.xlsx
December 22, 2021 - Events Adverse Events Withdrawals Due to Adverse Events Sponsor Quality
Skonnord, 2020 Outpatient Norway … Events Adverse Events Withdrawals Due to Adverse Events Sponsor Quality
No new evidence
E-4. … Events Adverse Events Withdrawals Due to Adverse Events Sponsor Quality
No new evidence
E-7. … Events Adverse Events Withdrawals Due to Adverse Events Sponsor Quality
Bloom, 2021 Postoperative to … Events Adverse Events Withdrawals Due to Adverse Events Sponsor Quality
No new evidence
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effectivehealthcare.ahrq.gov/sites/default/files/it-architecture-for-post-marketing-surveillance-arizona-cert.pdf
September 01, 2007 - for monitoring and detecting adverse drug events. … Detecting adverse drug events is a difficult problem. … 91% of the adverse
events. … from other adverse
clinical events under certain conditions. … They observe that the discrimination between adverse
drug events from other adverse clinical events
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/medicine-safety-call-center_research.pdf
September 01, 2007 - for monitoring and detecting adverse drug events. … Detecting adverse drug events is a difficult problem. … 91% of the adverse
events. … from other adverse
clinical events under certain conditions. … They observe that the discrimination between adverse
drug events from other adverse clinical events
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
December 01, 2020 - Evidence is insufficient to draw conclusions about serious adverse
events. … Evidence was insufficient to draw conclusions about serious adverse events. … Evidence was insufficient to draw conclusions about
serious adverse events. … In general, adverse events of these drugs are mild and transient. … However, adverse events of newer
medications require further study.
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effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - events; they may also include common adverse events and other specific adverse events
important … events, particularly for new drugs or
other interventions.
40
The adverse events identified by … events annually, collects them into a database,
42
and issues information about adverse drug
events … for intolerable or severe adverse events. … Uncommon or Rare Adverse Events
Evaluating comparative risks of uncommon or rare adverse events in
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - events; they may also include common adverse events and other specific adverse events
important … events, particularly for new drugs or
other interventions.
40
The adverse events identified by … events annually, collects them into a database,
42
and issues information about adverse drug
events … for intolerable or severe adverse events. … Uncommon or Rare Adverse Events
Evaluating comparative risks of uncommon or rare adverse events in
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effectivehealthcare.ahrq.gov/sites/default/files/diverticulitis-nomination-extra.pdf
July 03, 2018 - Resolution of
diverticulitis, recurrent
diverticulitis,
avoidance of surgery,
morbidity, mortality,
adverse … events
Diagnostic accuracy,
adverse events
Occult colorectal cancer,
recurrent diverticulitis … ,
adverse events
Resolution of
diverticulitis,
morbidity, mortality,
adverse events
Recurrent … diverticulitis,
adverse events
Timing All All Acute vs. convalescent All All
Setting Inpatient,
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effectivehealthcare.ahrq.gov/sites/default/files/s108.pdf
October 01, 2007 - events
on costs. … The costs of adverse drug events
in hospitalized patients. … Adverse Drug Events Prevention Study Group.
JAMA. 1997;277:307–311.
21. … Adverse drug events in
hospitalized patients. … Using a hospital information
system to assess the effects of adverse drug events.
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effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
December 01, 2020 - • Opioids are probably associated with increased risk of short-term adverse events
versus nonopioid … events, nausea, dizziness, and somnolence,
but serious adverse events are uncommon in randomized trials … Opioids were associated with increased risk of short-term adverse events (any
adverse event, study withdrawal … due to adverse events, dizziness and nausea) for both
comparisons. … Serious adverse events were uncommon, but studies were not designed to
assess risk of overdose, opioid