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Showing results for "adverse event".
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461. Fatty-Acids-Cardiovascular-Disease Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/fatty-acids-cardiovascular-disease_research-protocol.pdf
     April 02, 2015 - are benefits of very long chain polyunsaturated fatty acids (EPA and DHA) for reducing the risk of adverse … Adverse events: • What adverse effects are related to n-3 FA intake or biomarker concentrations ( … • What adverse events are reported specifically among people with CVD or diabetes (in studies of CVD … • Exclude n-3 FA dose ≥6 g/day (except for adverse events) Source: www.effectivehealthcare.ahrq.gov … density lipoprotein cholesterol [LDL-c], total/HDL-c ratio, LDL-c/HDL-c ratio, triglycerides) • Adverse

462. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
     October 01, 2015 - The most common adverse reactions occurring in patients treated with pirfenidone compared with placebo … patients may require a dose reduction to 100 mg, twice daily, or treatment interruption to manage adverse … The most common adverse reactions occurring in patients treated with nintedanib compared with placebo … impact potential, more data demonstrating reductions in transplantation-associated complications, adverse … However, two clinical experts stated that adverse events could reduce patient acceptance.41,47 One

463. Medical Therapies for Locally Advanced Gastric Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amended.pdf
     February 07, 2025 - events (grade 3, 4, 5) • Direct mild treatment adverse events (grade 1, 2) • Indirect adverse … for pain management) N/A Timing All KQs: Any follow-up duration for grade 3-5 or indirect adverse … events and quality of life; minimum of 1 year for grade 1-2 adverse events; minimum of 3 months for … For direct treatment adverse events (AEs) and indirect treatment-related AEs, we will prioritize using … We will summarize time-to-event outcomes (overall survival and progression-free survival) with hazard

464. Angina-Heart-Attack-Treatments Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
     January 01, 2014 - goals for patients with UA/NSTEMI involve the elimination of ischemic pain and the prevention of adverse … Finally, all three KQs consider safety risks, including adverse drug reactions, bleeding, and stent … The safety outcomes were framed to help identify adverse events, including adverse drug reactions and … • While the use of GPIs reduces the rates of the adverse events mentioned above, the tradeoff is … rates of cardiovascular mortality usually dominate the event rates for total mortality.

465. Restless-Legs Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
     November 01, 2012 - effects, dropouts, dropouts due to adverse effects, treatment discontinuation due to adverse effects … effects, and dropouts due to adverse effects. … effects, and patients reporting at least one adverse effect. … However, adverse effects of pharmacologic therapies and long-term treatment withdrawals due to adverse … Both short- and long-term adverse effects and treatment withdrawals due to adverse effects or lack

466. Evidence Summary - Comparative Effectiveness Review No. 249: Malnutrition in Hospitalized Adults: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-249-malnutrition-hospitalized-adults-evidence-summary_0.pdf
     October 01, 2021 - length of stay, activities of daily living, discharge disposition, hospital acquired conditions, or adverse … These studies had several shortcomings, including high risk of bias and poor reporting of adverse events

467. Evidence Summary - Comparative Effectiveness Review No. 249: Malnutrition in Hospitalized Adults: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-249-malnutrition-hospitalized-adults-evidence-summary.pdf
     October 01, 2021 - length of stay, activities of daily living, discharge disposition, hospital acquired conditions, or adverse … These studies had several shortcomings, including high risk of bias and poor reporting of adverse events

468. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb_surveillance.pdf
     July 06, 2015 - International geographic variation in event rates in trials of heart failure with preserved and reduced … Since the only trial evaluating an ARB did not report adverse event results, our results cannot be applied … event; FU=follow-up; SR=systematic review; MA=meta-analysis; IPD=individual patient data; CV=cardiovascular … and 30 (20%) on valsartan had one or more serious adverse event. … Since the only trial evaluating an ARB did not report adverse event results, our results cannot be

469. Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents - Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
     November 01, 2021 - Monitoring also includes assessment of any adverse effects of treatment. … In question 1d, we will assess whether the literature suggests whether these adverse effects differ … Questions 2 and 3 will review effectiveness as well as adverse outcomes. III. … event reporting) … event outcomes.

470. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/psoriasis-chronic_research-protocol.pdf
     January 10, 2012 - We did not move major adverse cardiovascular events (MACE) from final health outcomes to harms, because … , differential loss to followup, overall loss to followup, use of intention to treat, blinding of event … confounding, baseline differences, method to ascertain exposure, methods to ascertain outcomes, blinding of event … change scores will be calculated using the method proposed by Follman and colleagues. 22 In the event … The pooled effect estimate will be used with the range of control event rates from the trials included

471. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - What are the adverse effects or harms associated with imaging-based surveillance strategies? … What are the adverse effects or harms associated with using imaging techniques related to testing or … o Key Questions 1d, 2d, and 3d (Adverse Events or Harms)  Adverse effects or harms associated with … Summary of Protocol Amendments In the event of protocol amendments, the date of each amendment will … anxiety, adverse events secondary to venipuncture, contrast allergy, exposure to radiation) Adverse

472. Template for Reports Developed (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
     March 25, 2012 - What are the significant agent-specific harms/adverse effects of nonhormone therapies? … Question 4 Does effectiveness and adverse effects vary among subgroups of patients defined by … Also considered are consequential adverse effects among women using hormone therapies; these adverse … Finally, adverse events accompanying the use of nonhormone agents are also depicted. … ((((“adverse effects” [Subheading]) OR “complications” [Subheading]) OR ( “poisoning” [Subheading] OR

473. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1306.pdf
     January 01, 2016 - No serious adverse events were reported. … event reported in the 3-year, phase III clinical trial for the fluocinolone acetonide implant was … fluocinolone acetonide compared with those adverse-event rates in the sham group. 90 Clinical Pathway … Over 2 years, the most frequent ocular serious AE [adverse event] (SAE) and AE were cataract (2.1% … Exenatide study of cardiovascular event lowering trial (EXSCEL): a trial to evaluate cardiovascular

474. Disposition of Comments Report for Antiplatelet and Anticoagulant Treatments for Unstable Angina/Non-ST Elevation Myocardial Infarction (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_disposition-comments.pdf
     January 01, 2014 - We have added the missing TRITON-TIMI event rate. … bias, where sicker patients with more comorbidites are treated with a PPI and therefore have more adverse … We have added the missing TRITON-TIMI event rate. … Two adverse drug reactions values are presented and the type of adverse reaction is not shown. … drug reactions Dyspnea at 12 months Ticagrelor 1274/9235 Clopidogrel 717/9186 Adverse drug reactions

475. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
     June 15, 2010 - metabolic disturbance, Sleep, Cardiovascular system problems, Geriatric toxicity problems, Other common adverse … Note that in Embase alone there are over 7,000 articles that “focus” on adverse events relating to … collecting and reporting harms using the McHarm Tool; this tool has been specifically designed for adverse … suggest that industry sponsorship may lead to negative trials not being published15, that reporting of adverse … Is there evidence for biased reporting of published adverse effects data in pharmaceutical industry-funded

476. Nppv-Respiratory-Failure Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nppv-respiratory-failure_executive.pdf
     July 01, 2012 - continuous positive airway pressure (CPAP), associated with less morbidity, lower mortality, fewer adverse … In general, the figure shows that this CER compares morbidity, mortality, adverse events, and health … Adverse events considered are aspiration, secondary infections (including pneumonia and sinusitis), … The safety outcomes were framed to help identify adverse events, including hospital-acquired pneumonia … We included common outcomes of interest such as mortality and adverse events, but also examined more

477. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
     September 26, 2014 - Prespecified interim analysis of major adverse cardiovascular events is anticipated by mid-2015 and … After 6 months of treatment, the event rates decreased from 28 to 16 in the pump-only group vs 175 … No serious adverse events were reported. … Adverse event profiles were similar across groups. … Rate of serious adverse effects in a series of bevacizumab and ranibizumab injections.

478. Disposition of Comments for CER 165 Fecal Incontinence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
     March 21, 2016 - event reporting: 35.5% of patients required a device revision, replacement or explant. … Specifically, the majority of adverse event are resolved spontaneously, with re-programming of the device … possible that 25% of the 'community dwelling population' has FI - it might be that 25% had an ABL event … If you are really trying to discuss ostomy as a surgical adverse event, add ileostomy to colostomy, … Hull 2013 has been added to Appendix table F9 (KQ 2) of adverse effects.

479. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-radiation_technical-brief.pdf
     November 01, 2009 - Seventy-five percent of studies (188) reported the adverse events. … crude rates at specific followup durations (e.g., at 5 years or at the end of followup) or as time-to-event … The number of patients who experienced at least one severe or serious adverse event was not routinely … event or harm that was not already listed in the studies included in the literature scan. … Adverse events, harms, and safety issues reported

480. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - Research indicates that individuals can reduce their risk of obesity-related adverse health conditions … preventive practices for females of reproductive potential and immediate drug discontinuation in event … While several experts mentioned the uncertainty of long- term adverse events as a potential barrier … Adverse events were reported in 100% of patients in this study. … discontinuation rate, which they believe to be significant adverse factors.