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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_disposition-comments.pdf
April 02, 2013 - KQ 4: We appreciate the reviewer’s query
about whether this mortality is reasonably
considered an adverse … event (AE) in
reviewed interventions to prevent the
development of PTSD symptoms. … This
conceptualization of an adverse event is
consistent with how AEs are defined in
mental health … I suggest you might want to more clearly distinguish the source
event(s) from the aftermath. … and PTSD; caused by the event and causing
PTSD.)
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-supplementary-app-d.xlsx
January 01, 2023 - Possible that different definitions (for adverse events) or scales (for quality of life) and different … Possible that different definitions (for adverse events) or scales (for quality of life) and different … Objective outcomes (e.g., survival, adverse events) were centrally assessed, reducing potential bias. … assessment, and no protocol or statistical analysis plan is available, but standard approach used to assess adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostatic-hyperplasia-medications_research-protocol.pdf
April 21, 2015 - The proposed advantages over anticholinergics include potentially lower rates of
adverse effects and … Also, adverse events may occur at any point after the treatment is initiated.
IV. Methods
A. … Update on AUA guideline on the review of efficacy and adverse effects. … ((adverse or undesirable or harm* or serious or toxic or negative) adj3 (effect* or
reaction* or event … ((adverse or undesirable or harm* or serious or toxic or negative) adj3 (effect* or
reaction* or event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
January 09, 2020 - In addition to effectiveness, decisionmakers need information on potential adverse risks, and
special … Pain, function, pain relief satisfaction and quality of life,
harms/adverse events (including withdrawal … predicting risk of opioid
misuse, opioid use
disorder, or overdose
(KQ 1 h)
Mitigation strategies
Adverse … We will grade SOE for the two most critical health outcomes, pain,
function, quality of life, and adverse … treatment patterns of prophylactic and
acute migraine medications and incidence of opioid-related adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - adj2 (effect or effects or reaction or reactions or event or events or
outcome or outcomes)).mp. ( … Found no difference in withdrawals due to adverse events. … 2 trials found no statistically significant difference in risk of any assessed adverse event.
24-week … No difference in risk of withdrawal due to adverse events. … event. not applicable to
current practice.
24-week regimen of triple therapy with
telaprevir (pegylated
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - adj2 (effect or effects or reaction or reactions or event or events or
outcome or outcomes)).mp. ( … Found no difference in withdrawals due to adverse events. … 2 trials found no statistically significant difference in risk of any assessed adverse event.
24-week … No difference in risk of withdrawal due to adverse events. … event. not applicable to
current practice.
24-week regimen of triple therapy with
telaprevir (pegylated
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-239-episodic-migraine-comments.pdf
December 29, 2020 - administration and study settings (e.g., home, outpatient,
emergency room, and inpatient), lack of data on adverse … Evidence
was insufficient to draw
conclusions about serious adverse
events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
January 15, 2015 - The risks and adverse events of the
drugs are well-understood and include symptomatic hypotension, myalgia … What adverse events and complications have been associated with aggressive
medical therapy or renal … lipid-lowering drugs)
• Surgical repair
Outcomes
• Mortality, all cause
• Kidney function
o Event … therapy)
o Categorical (eg, better/worse)
o Continuous (ie, GFR, CrCl, SCr)
• Blood pressure
o Event … [Type text] [Type text] [Type text]
• ≥6 months (except adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-259-partial-breast-irradiation-executive-summary.pdf
January 01, 2023 - • Acute adverse events (AEs) were significantly fewer with PBI compared with
WBI, with no apparent … This highlights the need to investigate outcomes of
PBI among patients with adverse risk factors. … These advancements
result in improved dose homogeneity that may lower the risk for adverse events. … PBI is associated with
fewer acute adverse effects, but the risk of IBR among patients treated with … PBI who
have adverse clinical or pathologic features is unclear.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
September 30, 2010 - Thus, we will monitor all databases for adverse effects from significant risk
devices.
II. … Adverse events resulting from drugs.
2. … Adverse events resulting from nonpharmacological treatments. … rate - treatment group event rate). … rates multiplied by 1000:
(control group event rate - treatment group event rate)*1000
We will
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
April 01, 2013 - Adverse effects of psychotropic drugs (notably
second-generation antipsychotics) also may contribute … effects, and adverse effects (KQs 1–4). … For adverse effects, we
report significant worsening of psychiatric status and
discontinuations due … to adverse effects. … For adverse effects, we considered
discontinuation due to adverse effects and worsening of
psychiatric
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-asthma.pdf
April 01, 2019 - Events of Interest Medication adverse
events
Adverse events related to asthma medications.
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
June 01, 2014 - However, experts noted that patients would likely be concerned about potential adverse
events. … The researchers also reported that the most common adverse
events “included headache (35%), nausea … The most commonly reported (≥10%) adverse reactions in patients treated…across all
clinical studies … Of subjects receiving the recommended dose of 0.05
mg/kg/day, 88.3% (n=68/77) experienced an adverse … Many of these adverse reactions were reported in association with the underlying
disease and/or use
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause_executive.pdf
March 01, 2015 - What are the
significant agent-specific harms/adverse effects of
nonhormone therapies? … For the adverse
events question, trials included in Key Question 1 that also
reported adverse events … To place their magnitudes into context,
with control-group event rates of 20 to 60 percent, SMDs
can … Although
the ORs exceed relative risks when placebo group event
rates exceed 10 percent, they provide … The USPSTF review reported differences in event rates
with estrogen/progestin or estrogen compared with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
April 01, 2013 - KQ 6 summarizes the evidence
for the one trial that was identified that addressed adverse
events. … Only two trials reported
an incident that the authors classified as an adverse event. … Fewer children in TF-CBT
experienced the adverse event of removal from treatment
because of persistent … Typically, an intervention was based on
an event (maltreatment or involvement with CPS), rather
than … The Adverse Childhood Experiences (ACE) Study.
Am J Prev Med. 1998 May;14(4):245-58.
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
December 01, 2014 - However, experts
noted that patients would likely be concerned about potential adverse events. … The researchers also reported that the most common adverse
events “included headache (35%), nausea … The most commonly reported (≥10%) adverse reactions in patients treated…across all
clinical studies … Of subjects receiving the recommended dose of 0.05
mg/kg/day, 88.3% (n=68/77) experienced an adverse … Many of these adverse reactions were reported in association with the underlying
disease and/or use
-
effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
January 01, 2012 - Research indicates that individuals can reduce their risk of obesity-related adverse health conditions … While several experts mentioned the uncertainty of long-term adverse
events as a potential barrier … The potential was tempered by experts’ significant concerns about
reported adverse events. … However, multiple experts also noted the significant reported side effects and adverse
events and the … discontinuation rate, which they believe to be significant adverse factors.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
January 01, 2008 - the cost of treatment,
the severity of diseases that HSCT is used to treat, and the prevalence of adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0086_04-01-2009.pdf
January 01, 2009 - any commonly used dietary supplements decrease the
effectiveness of these medications or increase adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypothyroidism-hyperthyroidism-screening-treatment_research-protocol.pdf
March 11, 2010 - possible association with increased miscarriage and
neuropsychological complications in offspring, the adverse … • Adverse events
i. Psychological or social impact of false positive screening tests.
ii. … Adverse reactions are usually due to therapeutic overdosage and
resulting hyperthyroidism. … (effect$ OR reaction$ OR event$ OR outcome$) [tiab]
10. 8 AND 9
11. 10 OR 7 OR 6
P Patient issues … Summary of Protocol Amendments
In the event of protocol amendments, the date of each amendment will