-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0334_08-04-2010.pdf
January 01, 2010 - for clinical outcomes
among patients receiving clopidogrel treatment for the prevention of major
adverse … guiding treatment choice for
patients who require antiplatelet therapy for the prevention of major adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - Neuroleptic malignant syndrome is a rare but serious adverse effect. … For continuous adverse
event measures (e.g., weight or prolactin levels), we will extract the mean change … event is observed. … The dose of each medication that is
associated with an adverse event will be recorded to facilitate … Adverse!event!outcome!data!for!extraction!in!the!comparative!effectiveness!review!
Adverse!event!
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
April 01, 2012 - to adverse events)? … using the
DerSimonian and Laird random-effects model,33 and Peto
odds ratios were calculated when event … of
40 hypertensive patients with no comorbidities on
therapeutic doses of beta-blockers, a single event … events,42,73 renal dysfunction,42,73 serious adverse events,42
diarrhea,73 vomiting,73 nausea,73 adverse … What Is a Serious Adverse
Event? www.fda.gov/safety/medwatch/howtoreport/
ucm053087.htm.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
June 01, 2013 - had no adverse events data. … Data reported on adverse events also have several
limitations. … event category; thus, the rate estimate for most
adverse events is imprecise. … event rate calculation, meaning the
generalizability of the estimate is questionable. … As such, the rates of adverse
events may be biased and lower than actual.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
August 01, 2023 - (Effect Size/SOE)a
Any time Insufficient
evidence
No difference
+ No evidence
Harms/AEs – Adverse … Withdrawals due to AEs
(Effect Size/SOE)a
Any time No difference
+ No evidence No evidence
AEs = adverse … weeks
No difference
+ No evidence
3DCRT = three-dimensional conformal radiation therapy; AEs = adverse … SCC
or Cauda Equina Compression
(Effect Size/SOE)a
Timing NR No difference
+ No evidence
AEs = adverse … There may be no differences in pain
response or serious adverse events between concomitant use of EBRT
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/thromboembolism-update_research-protocol.pdf
February 17, 2016 - single classes on venous thromboembolism outcomes, treatment
adherence, major bleeding, and other adverse … postoperative) on venous thromboembolism outcomes, treatment
adherence, major bleeding, and other adverse … KQ 5 also
§ Symptomatic DVT
§ Proximal DVT
o Adherence (compliance) with treatment
• Adverse … events due to mechanical devices (as reported by authors)
o Adverse events due to IVC filter (as … reported by authors)
o Other clinically significant adverse events reported by studies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
February 01, 2019 - Harms and Adverse Events
a. … adverse events, according to drug class? … events, and serious adverse events. … events, serious adverse events,
overdose (intentional and unintentional),
misuse, and dependence … or severity of pain, underlying pain condition, presence of
medical and psychiatric comorbidities, event
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - event or may include events in the category of ―other adverse events.‖
In a recent systematic review … , the outcome of congestive heart failure reported as an adverse
event ranged from heart failure events … ―R‖ is the sum of the most serious adverse effect (scored from 1–5) and the second
most serious adverse … Multiple sclerosis patients' benefit-risk
preferences: serious adverse event risks versus
treatment … Crohn's disease patients' risk-benefit preferences:
serious adverse event risks versus treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - adverse events according to drug class? … No change in
conclusions
Abbreviations: AE=adverse event; CBD=cannabidiol; CR=controlled release; … event in the RCT was application site pain (36.6% overall; not
reported by treatment group).6 Due to … Harms and Adverse Events
a. … events, and serious adverse events.
-
effectivehealthcare.ahrq.gov/products/cardio-dental/research
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
May 01, 2017 - The number of publications
reporting each event, and the median (with 25th and 75th
percentiles) percent … Median percentage of patients and ears with adverse events associated with TT
placement
Adverse Event … event details
by study, and for study specific details, including design,
recruitment period, tube … the RCTs are systematically higher in both control
and intervention arms in the RCTs compared with event … Several adverse event categories have very wide
interquartile ranges (e.g. otorrhea, premature extrusion
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_overview.pdf
March 27, 2014 - In children with JIA, does the rate and type of adverse eventsf differ
between the various DMARDs or … How do the efficacy, effectiveness, safety, and adverse effects of
treatment with DMARDs differ among … with DMARDs, we focused primarily on serious infections and the development of cancer when assessing adverse … Other adverse events considered included mortality, hepatitis, bone marrow suppression, nausea or vomiting
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-executive-summary_0.pdf
May 01, 2023 - • Studies focused on evaluating changes in body weight/composition, adverse
events, length of hospital … Studies focused on evaluating
changes in body weight/composition, adverse events, length of hospital … mixed results, with some studies reporting a benefit
and some reporting no difference in reducing adverse … events, length of hospital
stay, or survival.31-45 Two low-risk-of-bias studies reported fewer adverse … One low-risk-of-bias study
reported that postoperative enteral nutrition reduced adverse events length
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
January 01, 2009 - If they exhibit adverse effects, they were excluded from being randomized into the trial. … Since only patients tolerating therapy were randomized, the trial found a very low incidence of adverse … drug events, no response)
Events rates markedly different than in community Event rates in treatment … Next, compare the event rates in the treatment and control groups to community averages. … In both scenarios, there is a significant reduction in the odds of the event with therapy and no statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
January 01, 2019 - event rates to be precise to the nearest 1
percent … † Restricting to larger studies will allow estimates of adverse event rates to be
increasingly precise … report results as per the
existing systematic review
For Key Questions 1b and 1c, we will focus on event … For Key Question 3, we will focus on event rates of the clinical outcomes and harms. … nonpharmacologic, elective
surgical) to their comparators, for their effects, primarily with ORs of event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-2-nonopioid-pharm-chronic-pain.pdf
April 01, 2022 - adverse events according to drug class? … event; CBD = cannabidiol; CR = controlled release; IR = immediate release; KQ = Key Question;
RCT = … Harms and Adverse Events
a. … adverse events according to drug class? … events, and serious adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
July 01, 2014 - hepatotoxicity, weight
gain, metabolic syndrome, gastrointestinal
symptoms, and loss of libid0)
• Overall adverse-event … reports, adverse events
associated with discontinuation of treatment, and
serious adverse events … differential loss to
followup or overall high loss to followup occurred, the
adequacy of exposure and event … For example,
if a medication has a lower adverse event profile but is
also less effective for a given … event profile is not a
reasonable therapeutic strategy.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief1-care-coordination.pdf
April 01, 2021 - disruptions in pain management, which could result in worsened quality of life,
function, and other adverse … persons with pain are often discharged
on opioids; such patients may be at risk for opioid-related adverse … transitional
care interventions represent a potential opportunity to optimize management and reduce adverse … entitled to Medicare with pain represent a potential opportunity to
optimize management and reduce adverse … 1
Outcomes Pain, function, quality of life, readmission, pain
management (including opioid use), adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief1-care-coordination.pdf
April 01, 2021 - disruptions in pain management, which could result in worsened quality of life,
function, and other adverse … persons with pain are often discharged
on opioids; such patients may be at risk for opioid-related adverse … transitional
care interventions represent a potential opportunity to optimize management and reduce adverse … entitled to Medicare with pain represent a potential opportunity to
optimize management and reduce adverse … 1
Outcomes Pain, function, quality of life, readmission, pain
management (including opioid use), adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
June 01, 2012 - No Signal
Adverse events:
Consistent to the original CER, the adverse events were not adequately assessed … Medical
treatment
Mortality:
HR= 0.016; CI= 0, 15.16; p= 0.616
Event Free Survival
Patient with … Adverse events
The evidence does not adequately
assess comparisons of adverse events
between medical … These adverse events occurred at
different centers and with
Different providers. … Revascularization (95% pts with stent) +
medical therapy vs. medical therapy
Cardiovascular event