-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-rept-1-acute-pain.pdf
May 01, 2022 - NSAID
Opioid increased risk of:
Any adverse event: RR
1.72 (95% CI 1.29 to 2.28)
Nausea: RR 2.72 … acetaminophen
Opioids increased risk of:
Any adverse event: RR
1.43 (95% CI 0.87 to 2.37)
Nausea … Opioids were associated with
increased likelihood of any adverse event (34% vs. 9%, RR 3.62, 95% CI … events versus an NSAID alone, including any
adverse event (30.2% to 51.0% vs. 23.2%), nausea (7.3% … , including any adverse event, nausea, dizziness, and
somnolence.
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
June 01, 2015 - event, versus 55.7% given placebo; serious adverse event
rates were 1.6%, 2.4% and 4.1%, respectively … Similar adverse event rates were reported for secukinumab 75 mg (57.5%), 150
3
mg (62.5%), and … However, some experts were concerned about the
adverse event rates reported.12,15 Some experts also … events, which could require additional adverse-event monitoring
while patients are taking lesinurad … event.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rapid-response-cardio-dental.pdf
July 01, 2023 - event rates in patients who
receive implanted cardiac devices other than surgical prosthetic valves … event rates and other relevant outcomes? … In
the rare event of a device infection due to an oral pathogen,
it is most likely to have arisen from … a bacteremia from a
common daily event such as toothbrushing or chewing food. … suggests that antibiotic
prophylaxis for dental procedures
is of little or no value in the rare
event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
April 01, 2015 - Event
At Least
1 Serious
Adverse
Event
Treatment
Discontinuation
for Adverse
Event
Comparator … AE = adverse event; IFN = interferon; NR = not reported; SPMS = secondary progressive multiple sclerosis … The included studies used a wide range of reporting
methods and adverse event categories that precluded … Studies reporting reasons for discontinuing medication
DMT
Total
Number
of Studies
Adverse
Event … Multiple sclerosis
patients’ benefit-risk preferences: serious adverse event risks versus
treatment
-
effectivehealthcare.ahrq.gov/products/high-risk-drugs/rapid-research
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … pharmacologic therapy for acute pain,
including any adverse event, study withdrawal
due to adverse … Large increases in withdrawal due to
adverse events were seen with oxcarbazepine. … Pain during the week or
month following the inciting event and
persistent opioid use were rarely reported
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-addendum-app.xlsx
May 29, 2025 - Outcome Measures Duration of Follow-Up Results - Primary Outcomes Results - Secondary Outcomes Harms and Adverse … See above
Addendum Appendix Abbreviations
Abbreviations for Addendum Appendix
Acronym Term
AE adverse … event
BPI Brief Pain Inventory
CT Computed Tomography
EBRT external beam radiation therapy
EQ-5D
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
May 29, 2025 - among$38,589$subjects.$
From$these,$38$deaths$and$13$strokes$were$reported.$$
•$ May$reflect$low$event … &ACEI&or&ARB)& treatment$led$to$a$similar$number$of$adverse$
$ events$and$serious$adverse$events.$& … &ACEI&or&ARB)&
$
Although$several$studies$collected$data$on$angioedema,$the$event$rates$were$very$low … $From$these,$38$
deaths$and$13$strokes$were$
reported.$$
•$ May$reflect$low$event$rates$
among$otherwise … &ACEI&or&
ARB)&
$
Although$several$studies$collected$data$
on$angioedema,$the$event$rates$were$
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
May 01, 2024 - Computerized Clinical Decision Support To Prevent Medication Errors and Adverse Drug
Events ........ … Reducing Adverse Drug Events Related to Anticoagulant
Use in Adults
9a. … involving
CDSS to reduce medication errors and adverse drug
events. … Adverse Events in Hospitals: A
Quarter of Medicare Patients Experienced
Harm in October 2018. … Reducing Adverse Drug Events Related to Anticoagulant Use in Adults
9a.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-202-bronchial-thermoplasty-asthma.pdf
December 01, 2017 - • BT causes more adverse events
(such as worsening of asthma
symptoms, respiratory infections,
and … • Patients treated with BT developed the following
common adverse events: bronchial irritation, chest … Serious adverse events
occurred more frequently in BT-treated patients than in
patients receiving sham … Serious adverse events attributed to BT
were infrequent, and no deaths were reported. … The risk of adverse events is higher early in treatment,
while benefit is typically observed weeks to
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
September 14, 2016 - We will also review the FDA Adverse Event
Reporting System (FAERS). … event.36
Data Synthesis
We will complete a qualitative synthesis for all questions. … Summary of Protocol Amendments
In the event of protocol amendments, the date of each amendment will … (McGraw Hill Concise Dictionary of Modern Medicine, 2002)
b) An adverse event is any undesirable experience … events (SAE): The event is serious and should be reported when the patient
outcome is: death, life-threatening
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_disposition-comments.pdf
September 01, 2011 - We have added the following
sentence as a Key Point: “Adverse event
rates may be underestimated by … In adverse event
analysis, page 45, why weren't open label run-in phase data in the
withdrawal studies … In the adverse event analysis,
we only included data from the RCT phases
of multiphase studies in order … Some examples of
imbalances in adverse event rates that favor the safety of placebo
over adalimumab … We have added the following
sentence as a Key Point for KQ3: “Adverse
event rates may be underestimated
-
effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
February 01, 2016 - We also evaluated adverse effects,
including serious adverse events (e.g., anaphylaxis
with medications … for acute LBP to
be associated with increased risk of any adverse event vs. placebo
(8 trials; RR, … in
risk of adverse events. … Yoga: Adverse events Low Reporting of harms was suboptimal, but adverse events, when
reported, were … vs. sham
ultrasound in risk of any adverse event (6.0% vs. 5.9%; RR, 1.03;
95% CI, 0.49 to 2.13) or
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_executive.pdf
April 01, 2013 - homicide)
• Perceived utility of
intervention
• Resilience
Characteristics
of trauma
(KQ 3)
Adverse … Critically ill patients32
Mortality Inconclusive, single trial (N=137) Insufficient
Incidence of adverse … their stays in the intensive care unit or in their overall
hospitalization) or in the incidence of adverse … effects before starting their study and use
or adapt validated instruments to measure adverse effects … Those variables could include pretrauma factors,
event characteristics, and peri-event responses.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_overview.pdf
January 17, 2014 - mellitus, what is the
comparative safety of the following treatment options in terms of the following adverse … addition to updating information on the potential benefits of available treatments, conclusions
regarding adverse … There have been a number of potential adverse
events associated with rosiglitazone (e.g. increased
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_executive.pdf
September 22, 2011 - event
management interventions versus usual care or placebo. … event management
interventions compared with usual care. … Adverse Event Management Interventions Versus
Usual Care/Placebo
Key Points
• There were no studies … of the effects of adverse event
management interventions on health outcomes besides
QOL. … Adverse Event Management Interventions Versus
Usual Care/Placebo
The strength of evidence on QOL was
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … pharmacologic therapy for acute pain, including any
adverse event, study withdrawal due to adverse … Large
increases in withdrawal due to adverse events were
seen with oxcarbazepine. … Pain during the week or month following
the inciting event and persistent opioid use were
rarely reported
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
December 29, 2015 - event, versus 55.7% given placebo; serious adverse event rates were 1.6%, 2.4%, and 4.1%,
respectively … Similar adverse event rates
were reported for secukinumab 75 mg (57.5%), 150 mg (62.5%), and placebo … 4 mg, and placebo, respectively; serious adverse event
rates were 4%, 10%, and 7%, respectively. … ; treatment-emergent adverse event rates were not reported. … , and placebo,
respectively; serious adverse event rates after 12 weeks were 2.3%, 1.2%, and 2.7%,
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_clinician.pdf
May 01, 2016 - systematic review evaluating the evidence regarding the effectiveness, comparative effectiveness, and
adverse … Topiramate also increased binge-eating abstinence.
�� Adverse effects of BED treatments were mainly … use of other sympathomimetic drugs for weight loss has been associated with serious
cardiovascular adverse … Table 2: Summary of Key Findings for Adverse Effects of Pharmacological Interventions
Intervention and … events, serious adverse events, and study discontinuations
clearly attributable to adverse events,
-
effectivehealthcare.ahrq.gov/products/chemotherapy-dental/research