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www.uspreventiveservicestaskforce.org/uspstf/document/other-supporting-document19468/tobacco-and-nicotine-use-prevention-in-children-and-adolescents-primary-care-interventions
April 28, 2020 - Adverse events were not well reported in trials of behavioral interventions, but no serious adverse events … not different between study drug and placebo; and adverse events experienced by those in the placebo … In the NRT trial, no serious adverse events were reported. 46 NRT was associated with increased risk … of headache, cough, abnormal dreams, muscle pain, and patch-related adverse events vs placebo ( P < … adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-depression-suicide-risk-children-adolescents
October 11, 2022 - Adverse childhood experiences influence the likelihood of experiencing mental health conditions such … Adverse childhood experiences may result from a complex interaction of familial, peer, or societal factors … These adverse childhood experiences may be blatant or subtle (eg, microaggressions) but are potentially … There were no significant differences in adverse events reported. 1 , 2
Response to Public Comment … Making the "C-ACE" for a culturally-informed adverse childhood experiences framework to understand the
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/perinatal-depression-preventive-interventions
February 12, 2019 - Importance: Depression during pregnancy and the postpartum period is relatively common and can have adverse … Both antidepressant trials systematically collected adverse event information. … No harms were associated with omega-3 fatty acids, although reports of adverse events were collected … No significant differences in the proportion of participants reporting gastrointestinal adverse effects … Antenatal psychosocial risk factors associated with adverse postpartum family outcomes.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/q_zxLD9JZFGoSPCrEHNk2g
June 11, 2019 - regimens were associated with
increased risk of long-term neuropsychiatric, renal, hepatic, and bone adverse … Hepatic and Renal Adverse Events
Analysis of data from the D:A:D study (n = 45 544) found long-
term … Some new evidence also indicates that
long-term hepatic, renal, and bone (fracture) adverse events are … as-
sociated with certain antiretroviral medications.28-31,33,36,37 The clini-
cal effect of such adverse … Mocroft A, Lundgren JD, Ross M, et al; Data
Collection on Adverse Events of Anti-HIV Drugs
(D:A:D) Study
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/screening-depression-suicide-risk-children-adolescents
October 11, 2022 - symptoms, response, remission, loss of diagnosis, mortality, functioning, suicide-related events, and adverse … Differences in suicide-related outcomes and adverse events for pharmacotherapy when compared with placebo … effects, withdrawals due to adverse effects, and suicidality. … One study 53-55 reported on adverse events, serious adverse events, and other harms during the 12- to … One additional study 58 reported 5 adverse events among 4 participants, but the occurrences were not
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/PdBbRgWKPMbHfeQeHkM242
February 01, 2010 - Adverse effects included elevated
heart rate, elevated blood pressure,
and adverse gastrointestinal effects … Serious adverse
events were reported for 2.7% of the
patients who were taking sibutra-
mine and �1% of … Adverse
events occurred in 3% of the patients
who received orlistat compared with
2% of the patients … They also commonly experi-
enced mild-to-moderate adverse
gastrointestinal effects, with 20% to
30% reporting … Incidence and risk factors for
perioperative adverse respiratory events in
children who are obese.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/3w8Wr9wwAyAqUJWmJo_bL-
February 01, 2014 - Studies of any design were included if they described
potential adverse effects, including inaccurate … No studies
described adverse effects of the risk models. … Adverse effects for participants are of placebo-
controlled trials relevant to mutation carriers. … Adverse effects include surgical complications, long-
term physical effects, and distress. … Few studies described adverse effects.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/SUHq3jffCaucDobFXKewQ_
February 01, 2013 - health care settings for reduc-
ing child abuse and neglect and related health outcomes, as well as
adverse … Data Synthesis: Eleven fair-quality randomized trials of interven-
tions and no studies of adverse effects … of adverse
effects were not identified by the literature searches. … No adverse ef-
fects were reported by participants (Dubowitz H. Personal
communication.). … 1 trial of a clinic-based
intervention
RCT Studies of adverse
effects were
lacking.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/intimate-partner-violence-abuse-older-vulnerable-adults
February 09, 2023 - /neglect and associated physical and mental morbidity (e.g., rates of emergency department visits); adverse … /neglect and associated physical and mental morbidity (e.g., rates of emergency department visits); adverse … anxiety, or depression); sexual trauma, unintended pregnancy, and sexually transmitted infections; adverse … anxiety, or depression); sexual trauma, unintended pregnancy † ,and sexually transmitted infections; adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/osteoporosis-screening
November 18, 2021 - KQ 5 (Treatment harms):
Total adverse events.
Total serious adverse events. … Specific serious adverse events: Major cardiovascular events (i.e., myocardial infarction, stroke, cardiovascular … Discontinuations because of adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary39/obesity-in-children-and-adolescents-screening-2010
January 15, 2010 - , any serious adverse event, or discontinuation caused by adverse events. … resulting from adverse effects were low and similar between groups. … ) discontinued treatment because of these adverse effects. … Serious adverse effects were also uncommon. … Arrow 3 curves down and ends at an oval reading "Adverse effects."
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/drug-use-illicit-screening-january-2008
January 15, 2008 - Several clinical trials of pharmacotherapy for drug misuse have reported mild to serious adverse events … The specific adverse events noted to occur more frequently in the treatment arm of trials (compared to … Adverse events ranging from mild (e.g., elevated liver function tests) to serious (e.g., seizures) have … The adverse events reported more frequently in the treatment arm of trials (compared to placebo) have … Adverse effects of cannabis on health: an update of the literature since 1996.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/Qh7NQD6ZEynjyRso7L5-gS
January 15, 2008 - Several clinical trials of pharmacotherapy for drug misuse
have reported mild to serious adverse events … The specific adverse events noted to
occur more frequently in the treatment arm of trials (compared … Discussion
Burden of disease: The adverse health effects of illicit drug use can be
significant, … The adverse events reported more frequently in the treatment arm of trials
(compared to placebo) have … Adverse effects of cannabis on health: an update of the
literature since 1996.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication
September 26, 2019 - Reviewed
Does aspirin reduce adverse … Does the effectiveness of aspirin for reducing adverse health outcomes vary by subpopulations defined
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/latent-tuberculosis-infection-screening
May 02, 2023 - Treatment Discontinuation With Isoniazid
Rates of treatment discontinuation because of adverse events … A total of 345 patients (1.8%) receiving isoniazid discontinued treatment because of adverse events, … The RR of discontinuation due to adverse events among patients treated with isoniazid vs placebo was … Rates of discontinuation because of adverse events were reported in all 4 included RCTs, but 1 trial … Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid:
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/kHT3WGUaG2wTz2pF_ke7bn
osteoporotic fractures§, clinical
vertebral fractures, any clinical
fragility fractures
KQ5:
Total adverse … events
Total serious adverse events
Specific serious adverse events:
major cardiovascular events … gastrointestinal events, rebound
fractures after discontinuing
denosumab treatment
Discontinuations because of
adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/syphilis-infection-in-pregnancy-screening-september-2018
September 04, 2018 - association of implementing a screening program with the incidence of congenital syphilis and other adverse … During this same period, in pregnant women infected with syphilis, the incidence of all adverse outcomes … review supports the effectiveness of identification and treatment of syphilis in pregnancy to avoid adverse … Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. … Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/syphilis-infection-in-pregnancy-screening-september-2018
September 04, 2018 - Evidence from observational studies demonstrates fewer adverse pregnancy outcomes among pregnant women … During the same time, the incidence of adverse pregnancy outcomes decreased from 42.7% to 19.2%, and … Effective treatment with antibiotics can prevent congenital syphilis and significantly decrease adverse … Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. … Reported estimates of adverse pregnancy outcomes among women with and without syphilis: a systematic
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/KFZpoMBYuoo8TRW6nhRev8
October 23, 2023 - event: 10% (263/2694) vs 10% (266/2693) in
primary (interim) analysis
Grade ≥3 kidney adverse event: … Clinical health outcomes Adverse events
Long-acting injectable cabotegravir vs daily oral TDF/FTC … event: 5.3% (120/2280) vs 5.3% (121/2282)
Grade 3 or higher adverse event: 31.9% (727/2280) vs 33.6% … event: 2.0% (33/1614) vs 2.0% (33/1610)
Grade 3 or higher adverse event: 17.1% (276/1614) vs 17.4%
( … All adverse events were grade
1 except in 1 patient with grade 2 symptoms.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan97/breast-cancer-screening-january-2016
July 17, 2014 - c Morbidity includes: physical adverse effects of treatment, quality of life measures, and other measures … What are the rates of specific adverse effects of current treatment regimens for invasive breast cancer … 2, 4: Reduced incidence of advanced breast cancer and treatment-related morbidity (i.e., physical adverse … Harms
KQs 5, 6: False-positive findings; anxiety; adverse effects on quality of life; false-positive … Contextual Question 1
U.S. rates of specific adverse effects of current treatment regimens for