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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis-june-2019
June 11, 2019 - PrEP was associated with an increased risk of renal adverse events (12 trials; RR, 1.43 [95% CI, 1.18 … -1.75]; I 2 = 0%; ARD, 0.56% [95% CI, 0.09%-1.04%]) and gastrointestinal adverse events (12 trials; … RR, 1.63 [95% CI, 1.26-2.11]; I 2 = 43%; ARD, 1.95% [95% CI, 0.48%-3.43%]); most adverse events were … PrEP regimen and any adverse event except for gonorrhea and chlamydia infection ( Table 3 ). … , with variability in cause of withdrawal (clinical or laboratory adverse event) and whether adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan37/vitamin-d-deficiency-screening
March 24, 2014 - undergo screening for vitamin D deficiency may be identified as being vitamin D deficient or experience adverse … the pathway for those who are vitamin D deficient is receiving treatment for vitamin D deficiency and adverse … What are the adverse effects of treatment of vitamin D deficiency with vitamin D supplementation? … Are there differences in adverse effects between patient subgroups (as defined by risk factors for vitamin … Health outcomes include:
Mortality
Renal outcomes (e.g., stones)
Soft tissue calcification
Adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan54/colorectal-cancer-screening
April 17, 2014 - Fecal DNA test
Blood screening test:
mSEPT9
a) What are the adverse … b) Do adverse effects vary by important subpopulations (e.g., by age)? … mm, 6–9 mm, ≥10 mm)
By location in colon (e.g., proximal versus distal)
KQ 3: Serious adverse … abdominal symptoms, and cardiovascular events; extra-colonic findings and subsequent diagnostic workup and adverse … advanced neoplasia (composite outcome of advanced adenomas and colorectal cancer)
KQ 3: Minor adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan102/chronic-obstructive-pulmonary-disease-screening
May 15, 2014 - What are the adverse effects of screening for COPD using prebronchodilator spirometry? … What are the adverse effects of screening for COPD, including the impact of targeted preventive services … What are the adverse effects of COPD treatment in this population? … negative predictive value (per person); diagnostic yield by disease severity
KQs 4, 6, 8: Serious adverse … unexpected or unwanted medical attention and/or resulting in death (e.g., requiring hospitalization); adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan37/vitamin-d-deficiency-screening-november-2014
March 24, 2014 - undergo screening for vitamin D deficiency may be identified as being vitamin D deficient or experience adverse … the pathway for those who are vitamin D deficient is receiving treatment for vitamin D deficiency and adverse … What are the adverse effects of treatment of vitamin D deficiency with vitamin D supplementation? … Are there differences in adverse effects between patient subgroups (as defined by risk factors for vitamin … Health outcomes include:
Mortality
Renal outcomes (e.g., stones)
Soft tissue calcification
Adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan102/chronic-obstructive-pulmonary-disease-screening-2016
May 15, 2014 - What are the adverse effects of screening for COPD using prebronchodilator spirometry? … What are the adverse effects of screening for COPD, including the impact of targeted preventive services … What are the adverse effects of COPD treatment in this population? … negative predictive value (per person); diagnostic yield by disease severity
KQs 4, 6, 8: Serious adverse … unexpected or unwanted medical attention and/or resulting in death (e.g., requiring hospitalization); adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan54/colorectal-cancer-screening-june-2016
April 17, 2014 - Fecal DNA test
Blood screening test:
mSEPT9
a) What are the adverse … b) Do adverse effects vary by important subpopulations (e.g., by age)? … mm, 6–9 mm, ≥10 mm)
By location in colon (e.g., proximal versus distal)
KQ 3: Serious adverse … abdominal symptoms, and cardiovascular events; extra-colonic findings and subsequent diagnostic workup and adverse … advanced neoplasia (composite outcome of advanced adenomas and colorectal cancer)
KQ 3: Minor adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
May 23, 2019 - failure
Mortality (all-cause, cardiovascular disease–related, cancer-related)
KQs 2, 4:
Serious adverse … events (as defined by the study, or those likely requiring medical attention)
Withdrawals due to adverse … events
Nonserious adverse events based on self-report or objective measurements, reported by at least
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/obesity-in-adults-interventions
March 31, 2016 - or pharmacotherapy interventions for weight loss or weight loss maintenance are associated with any adverse … What are the adverse effects of primary care–relevant behavioral and/or pharmacotherapy weight loss and … sleep apnea)
Proportion of individuals taking medication for an obesity-related condition
KQ 3: Adverse … effects
Psychological adverse events related to counseling or medication
KQ 1:
Functioning … trials, including cluster randomized trials
Large cohort or case-control studies reporting serious adverse
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions-september-2015
September 21, 2015 - The USPSTF also evaluated adverse events reported at any time point. … Adverse events related to other forms of behavioral interventions were not reported. … No significant increase in major cardiovascular adverse events was found (RR, 1.38 [CI, 0.58 to 3.26] … A trend toward reduction in major cardiovascular adverse events was found in the bupropion SR group ( … Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/hepatitis-c-screening
March 02, 2020 - event data, the pooled rate of any adverse event was 73.3%. 1 Rates of serious adverse events (1.9% … Five trials reported no withdrawals due to adverse events; 1 trial reported a serious adverse event ( … The rate of any adverse event was 27% in 1 trial and 71% to 84% in 4 trials. … fatigue (7 trials), and 3% to 28% for gastrointestinal adverse events (nausea, vomiting, or diarrhea … and withdrawal due to adverse effects.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/prediabetes-type2-diabetes-children-adolescents-screening
September 13, 2022 - In 1 study, gastrointestinal adverse events were more commonly reported by those taking metformin than … Gastrointestinal adverse events, infections, and muscle aches and pains were less common among youths … Gastrointestinal Adverse Events
Gastrointestinal adverse events were common in both studies. … Other Adverse Events
Both studies reported other adverse events; types of events reported (and definitions … The 16-week trial 16 reported that few participants had serious adverse events, all deemed unrelated
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/bQNXFv9Q5uaAQvWH6B7VWV
June 11, 2019 - PrEP was associated with an increased risk of
renal adverse events (12 trials; RR, 1.43 [95% CI, 1.18 … -1.75]; I2 = 0%; ARD, 0.56% [95% CI,
0.09%-1.04%]) and gastrointestinal adverse events (12 trials; RR … , 1.63 [95% CI, 1.26-2.11];
I2 = 43%; ARD, 1.95% [95% CI, 0.48%-3.43%]); most adverse events were mild … (n = 2120) found no significant difference in risk of any adverse preg-
nancy outcome.34
For all adverse … with variability in
cause of withdrawal
(clinical or laboratory
adverse event) and whether
adverse event
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/-wqedxmwdpdE5BmzcBeTmn
December 01, 2009 - events and early dis-
continuation due to adverse effects. … None of the adverse effects of interest to our review above
6. … The abstract did not mention any serious adverse events. … No mention of serious adverse effects was found in the abstract. … No mention of serious adverse effects was found in the abstract.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan88/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions
February 18, 2014 - individuals with mental health conditions, lead to improved health outcomes, tobacco abstinence, or adverse … What adverse events are associated with tobacco cessation interventions? … Tobacco cessation/tobacco abstinence (continuous abstinence or point prevalence abstinence)
KQ 3: Adverse … worsening of symptoms such as depression, anxiety, psychosis; loss of associates or friends)
Adverse
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan88/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions-september-2015
February 18, 2014 - individuals with mental health conditions, lead to improved health outcomes, tobacco abstinence, or adverse … What adverse events are associated with tobacco cessation interventions? … Tobacco cessation/tobacco abstinence (continuous abstinence or point prevalence abstinence)
KQ 3: Adverse … worsening of symptoms such as depression, anxiety, psychosis; loss of associates or friends)
Adverse
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www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/tobacco-smoking-cessation-in-adults-including-pregnant-women-interventions
June 02, 2020 - Cardiac adverse events and serious adverse events did not differ by type of NRT. 31
The USPSTF considered … events (RR, 1.30 [95% CI, 1.00 to 1.69]; k=33; n=9,631), 32 cardiovascular adverse events (RR, 1.03 … events or cardiovascular severe adverse events was found. 12 No statistically significant increase in … Adverse events associated with nicotine replacement therapy (NRT) for smoking cessation. … be associated with an increased risk of general severe adverse events.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication
June 21, 2022 - effects, 54 , 81 serious adverse effects, 31 or withdrawals due to adverse effects, 48 no group differences … were found, although there were very few serious adverse effects or withdrawals due to adverse effects … The 3 trials that reported the total number of adverse events, 51 , 77 serious adverse events, 77 or … events, 61 any serious adverse events, 28 and withdrawals due to adverse events 30 , 53 identified … effects, any serious adverse effects, and withdrawal due to adverse effects sparely reported; kidney
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/weight-loss-prevent-obesity-related-morbidity-mortality
May 18, 2023 - mellitus
Hypertension
Dyslipidemia
Cardiorespiratory fitness measures
KQ 3: Harms:
Any adverse … treatment-related harm after initiation of the intervention, including:
Any adverse event or serious … adverse event
Withdrawals or discontinuation of medication due to adverse effects
Unhealthy weight
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/behavioral-counseling-interventions-promote-healthy-diet-physical-activity-weight-loss-prevent-cardiovascular-disease-adults
May 18, 2023 - mellitus
Hypertension
Dyslipidemia
Cardiorespiratory fitness measures
KQ 3: Harms:
Any adverse … treatment-related harm after initiation of the intervention, including:
Any adverse event or serious … adverse event
Withdrawals or discontinuation of medication due to adverse effects
Unhealthy weight