-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
May 29, 2025 - Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. … NR
Serious adverse events: none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs … B
% (n/N)
Any adverse event: 88.4% (190/215) vs. 85.2% (184/216), RR 1.02 (95% CI 0.88 to 1.18)
Serious … adverse events: 13% (28/215) vs. 19.4% (42/216), OR 0.64 (95% CI 0.38 to 1.04)
Withdrawals due to adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
May 29, 2025 - Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. … NR
Serious adverse events: none in any group
Withdrawals due to adverse events
6 months: 10% (5/49) vs … B
% (n/N)
Any adverse event: 88.4% (190/215) vs. 85.2% (184/216), RR 1.02 (95% CI 0.88 to 1.18)
Serious … adverse events: 13% (28/215) vs. 19.4% (42/216), OR 0.64 (95% CI 0.38 to 1.04)
Withdrawals due to adverse
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
January 01, 2007 - Many questions remain
about the risks of these agents across a spectrum of
adverse events from relatively … In general, adverse events did not differ significantly
between biologic and synthetic DMARDs. … Studies were
too small to assess reliably differences in rare but
severe adverse events. … Studies, however, were too small to assess
reliably differences in rare but severe adverse events. … The
groups did not differ in serious adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
December 01, 2011 - Differences in Harms (Adverse Events)
(KQ 4a)
We analyzed adverse-events data from 92 head-to-head
efficacy … Methods of adverse-events assessment in efficacy trials
differed greatly. … , and somnolence were
commonly and consistently reported adverse events. … on most serious
adverse events is insufficient to draw firm conclusions. … Other Severe Adverse Events
The existing evidence on the comparative risk for rare
but severe adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_clinician.pdf
August 01, 2015 - The
present review assessed the comparative effectiveness and
adverse effects of 3DCRT, IMRT, SBRT, … This is a summary of a systematic review update evaluating recent evidence on the effectiveness and adverse … Summary of Key Findings and Strength of Evidence for the Benefits and Adverse Effects of Radiotherapy … 3DCRT, SBRT, and PBT:
�– In achieving tumor control and improving patient survival
�– In reducing adverse … risk of xerostomia might be reduced with the
use of IMRT versus 3DCRT
�� The potential long-term adverse
-
effectivehealthcare.ahrq.gov/products/high-risk-drugs/rapid-research
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - This includes:
• Overall adverse events.
• Specific adverse events. … • Withdrawals and time to withdrawal due to adverse
events. … • Persistence and reversibility of adverse events.
3. … Twelve studies provided adverse-events data for FGAs
versus SGAs. … Adverse events were reported in 36 studies comparing
SGAs with placebo.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - Outcomes including efficacy, impact on quality of life and neurocognition, and
adverse effects are important … • We did not detect consistent differences in serious adverse events, number of
reported adverse … events, adverse events, radiation
necrosis, headaches, fatigue, seizure, vomiting. … Risk of bias varied, 25 trials were terminated
early and the quality of adverse assessment and reporting … Adverse Events
We found no difference in serious adverse events when comparing WBRT plus SRS
with
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-244-safety-of-vaccines.pdf
May 25, 2021 - However, we do
provide all rates of key adverse
events in the Summary of Findings
tables. … We agree that the timing of each
adverse event relates to the vaccine
and particular adverse event. … Maybe “A limited number of studies
included listed adverse events
stratified…”. … Peer Reviewer
#5
Results p. 36, line 43: States “severe and
serious adverse events”. … We pre-specified key adverse events
of interest with our technical expert
panel.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_clinician.pdf
August 01, 2017 - review that evaluated current evidence regarding the effectiveness, comparative effectiveness,
and adverse … The systematic review assessed the efficacy, comparative
effectiveness, and adverse effects of a broad … Psychological and Behavioral Therapy: Adverse Effects
�� Evidence was insufficient regarding the adverse … Pharmacological Therapy: Adverse Effects (See Table 3)
�� Evidence regarding the long-term (more than … and
fractures, head injuries, dementia, and cancer.
�� FDA labels warn of several potential severe adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-200-post-acs-depression.pdf
November 01, 2017 - effects
• Depression-related outcomes
–
–
•
•
Adverse effects of treatments
Weight … effects 1 study RCT Unknown Imprecisea No difference,
findings not
reported by
specific adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; HR=hazard ratio; MACE=major adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; HR=hazard ratio; MACE=major adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; MACE=major adverse cardiovascular
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
February 01, 2018 - events and may include common adverse events or other adverse events
important to clinicians and patients … adverse
event,” or “any serious adverse event”; rather, the reports generally focused on specific adverse … “serious adverse events” or “withdrawal due to adverse events,” particularly when
evaluating head-to-head … 4) Are there general (non-specific) harms (e.g., any adverse event, any serious adverse event,
withdrawal … Are there general (non-specific) harms (e.g., any adverse event, any serious adverse event,
withdrawal
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update-surveillance-160328.pdf
May 29, 2025 - $events,$withdrawals$due$to$adverse$events,$serious$adverse$
events$reported,$withdrawal$rates,$switch … $$
Click$here$to$enter$text.$
(
Withdrawals$due$to$adverse$events$$
! … &ACEI&or&ARB)& treatment$led$to$a$similar$number$of$adverse$
$ events$and$serious$adverse$events.$& … $Moreover,$aliskiren$and$ARB$treatment$led$to$a$similar$number$of$adverse$events,$severe$adverse$events … ,$and$withdrawal$due$to$
adverse$events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
December 01, 2010 - Outcomes: Disorder-specific and -nonspecific adverse events:
1) Overall adverse events.
2) Specific … adverse events:
a. … withdrawal because of adverse events, and
persistence and reversibility of adverse events … For questions about adverse effects, we will search the U.S. … a dose-
related adverse-event analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
May 07, 2010 - event rates, overall adverse event
rates, and withdrawals due to adverse events, withdrawal rates, … switch
rates)
o Specific adverse events (including, but not limited to, weight gain,
impaired renal … events
•Withdrawals due to adverse events
•Serious adverse events reported
•Withdrawal rates
•Switch … Also, adverse
events (including, but not limited to, weight gain, impaired renal function, angioedema … events, withdrawals due to adverse events, serious adverse events
reported, withdrawal rates, switch
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/glucocorticoid-injections_clinician.pdf
June 01, 2016 - Brief Summary
of Findings for Clinicians
KEY CLINICAL ISSUE
What are the relative effectiveness and adverse … This trial also sought
to compare the adverse effects of epidural
injections of glucocorticoids plus … There were no differences be-
tween injection approaches at 6 weeks.
»» There were more reported adverse … Serious adverse events (hospitalization
or surgery) were rare among all patients.
»» There were higher … Furthermore, the potential adverse effects of systemic glucocor-
ticoids (e.g., elevated blood glucose
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - Serious adverse events are more common
in patients who received lasmiditan than placebo. … Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … pharmacologic therapy for acute pain, including any
adverse event, study withdrawal due to adverse … Large
increases in withdrawal due to adverse events were
seen with oxcarbazepine.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - Adverse effects of interest include
but are not limited to nausea, diarrhea, headache, tremor, daytime … Also,
adverse events may occur at any point after the treatment is received. … Also, adverse events may occur at any
point after the treatment is received.
IV. … events
Withdrawals because of
adverse events
Discontinuation rates because
of adverse events … Serious adverse events
Specific adverse events or
withdrawals because of specific
adverse events
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - To date, no study has evaluated proximal
clinical measures, long-term effects, and adverse events
among … Gastrointestinal adverse events/problems. … Metformin monotherapy was associated
with more frequent adverse events compared with the
combination … , and consistently report all adverse
events (not using aggregated events). … medications in withdrawals due to unspecified adverse events.
events
4&5k.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
March 23, 2019 - events
o Maternal
Serious maternal adverse events*
• “Serious” adverse events (including those … events*
o Fetal/infant
Serious fetal/infant adverse events*
• “Serious” adverse events (including … events
o Maternal
Serious maternal adverse events*
• “Serious” adverse events (including those … events*
o Fetal/infant
Serious fetal/infant adverse events*
• “Serious” adverse events (including … ) due
to neonatal/infant adverse events.