-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
June 01, 2011 - The direct
adverse events, tolerability, Low (DRI vs. … In the four studies that did report episodes of
ARB) angioedema, this adverse event was observed only … event rates, overall adverse event rates, and withdrawals due to adverse events, withdrawal rates, and … events, withdrawals due to adverse events, serious adverse events reported,
withdrawal rates, and switch … rates], as the latter may or may not be due to identifiable adverse events.)
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/draft-report-plant-based-treatment.pdf
March 01, 2021 - Prioritized outcomes included pain, function, and adverse events. … effects and some less frequent but serious adverse
effects. … No
adverse events were reported. … , 30 percent did not report serious adverse events, and 65
percent did not report the overall adverse … Similarly, adverse events such as cannabis use disorder, cognitive deficits, and serious adverse
events
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-risk-drugs-protocol.pdf
July 27, 2023 - Response Protocol
Project Title: Making Healthcare Safer IV:
Protocols for High-Risk Drugs: Reducing Adverse … The “Protocols for High-Risk Drugs:
Reducing Adverse Drug Events Related to Anticoagulants” as a patient … effects (e.g., bleeding).7,8 The 2019 National Action Plan for Adverse Drug Event
Prevention (ADE … US
Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014. … Advancing Medication
Safety: Establishing a National Action Plan for Adverse Drug Event Prevention.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
March 01, 2013 - specific adverse events. … Key Findings
Overall
• Adverse effects assessed by withdrawals and
withdrawals due to adverse effects … The two trials that reported specific adverse events
reported no individual adverse event in more than … (e.g., any,
serious adverse effects, adverse effects causing withdrawal,
predefined specific adverse … conditions as
well as any adverse events, serious adverse events, adverse
events causing withdrawal
-
effectivehealthcare.ahrq.gov/products/COVID-19-pharmaceutical-treatments/research
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effectivehealthcare.ahrq.gov/products/restless-legs/research
November 27, 2012 - assessed RLS symptom impact, sleep scale scores, disease-specific quality of life, withdrawals, and adverse … We included observational studies that assessed long-term (>6 months) treatment adverse effects and withdrawals … Dopamine agonists resulted in more patients who experienced at least one adverse event (high-strength … Treatment withdrawals were due to lack of efficacy (6% to 37%) as well as augmentation and other adverse … Adverse effects of pharmacologic therapies and long-term treatment withdrawals due to adverse effects
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effectivehealthcare.ahrq.gov/products/major-depressive-disorder/research
December 08, 2015 - Patients treated with SGAs had a higher risk of experiencing adverse events or discontinuing treatment … because of adverse events than patients treated with CBT, acupuncture, or St. … overall findings indicated no statistically significant differences in benefits but a lower risk of adverse … SGAs, in general, lead to a higher risk of adverse events than nonpharmacological treatment options. … The evidence is insufficient to form conclusions about differences in serious adverse events, such as
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-outcome-measure-harmonization-depression.pdf
November 01, 2020 - Events of
Interest
Adverse Events Depression treatment-related adverse events. … The adverse events measure also required a modification to capture adverse events related to
procedures … Additional
procedure codes were added to the Adverse Event value sets. … Potential challenges related to the
availability of PHQ-9, adverse event, suicide, and mortality data … Adverse Events Data
The intent of the adverse events measure is to capture all adverse events related
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-outcome-measure-harmonization-depression.pdf
November 01, 2020 - Events of
Interest
Adverse Events Depression treatment-related adverse events. … The adverse events measure also required a modification to capture adverse events related to
procedures … Additional
procedure codes were added to the Adverse Event value sets. … Potential challenges related to the
availability of PHQ-9, adverse event, suicide, and mortality data … Adverse Events Data
The intent of the adverse events measure is to capture all adverse events related
-
effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
October 01, 2007 - ORIGINAL ARTICLE
Real-Time Vaccine Safety Surveillance for the Early
Detection of Adverse Events
Tracy … events, hold promise
to allow earlier identification of adverse events. … Active surveillance of vaccine
safety: a system to detect early signs of adverse events. … Poisson sequential sampling modified towards maximal safety in
adverse event monitoring. … Prompt, active, population-based identification of adverse drug
reaction signals.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - The
intranasal route was common in studies reporting adverse
events for the comparison of opioids versus … Analytic framework
Abbreviations: AE=adverse event; KQ=Key Question
Data Sources
We searched MEDLINE … Opioids may cause fewer adverse events than
ketamine, primarily administered IN. … Opioids may cause
more adverse events than NSAIDs, administered
primarily IV. … evidence suggests that opioids may
cause fewer total adverse events than ketamine.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
September 01, 2019 - The
intranasal route was common in studies reporting adverse
events for the comparison of opioids versus … Analytic framework
Abbreviations: AE=adverse event; KQ=Key Question
Data Sources
We searched MEDLINE … Opioids may cause fewer adverse events than
ketamine, primarily administered IN. … Opioids may cause
more adverse events than NSAIDs, administered
primarily IV. … evidence suggests that opioids may
cause fewer total adverse events than ketamine.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - Serious adverse events are more
common in patients who received lasmiditan than
placebo. … Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … pharmacologic therapy for acute pain,
including any adverse event, study withdrawal
due to adverse … Large increases in withdrawal due to
adverse events were seen with oxcarbazepine.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-childhood-protocol.pdf
August 06, 2018 - Effects"] or [mh
/AE,CI,DE,MO,PO,TO] or adverse effect*:ti,ab or adverse event*:ti,ab or
adverse … reaction*:ti,ab or "adverse outcome":ti,ab or "adverse outcomes":ti,ab
or [mh "Adverse Drug Reaction … Effects" OR TX
“adverse effect” or TX “adverse event” OR TX “adverse
events” OR TX "adverse outcome … Effects"] or [mh
/AE,CI,DE,MO,PO,TO] or adverse effect*:ti,ab or adverse event*:ti,ab or
adverse … Effects" OR
TX “adverse effect” or TX “adverse event” OR
TX “adverse events” OR TX "adverse
outcome
-
effectivehealthcare.ahrq.gov/products/childhood-depression/protocol
August 24, 2018 - *:ti,ab or "adverse outcome":ti,ab or "adverse outcomes":ti,ab or [mh "Adverse Drug Reaction Reporting … Effects" OR TX “adverse effect” or TX “adverse event” OR TX “adverse events” OR TX "adverse outcome" … OR TX "adverse outcomes" OR TX “adverse reaction” OR TX “adverse reactions” OR TX “chemically induced … *:ti,ab or "adverse outcome":ti,ab or "adverse outcomes":ti,ab or [mh "Adverse Drug Reaction Reporting … Effects" OR TX “adverse effect” or TX “adverse event” OR TX “adverse events” OR TX "adverse outcome"
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
February 01, 2018 - Harms are Adverse Events or
Complications
• Definition of harms:
► Adverse events or complications … What is a Serious Adverse Event? … What is a Serious Adverse Event? … Consider Composite
Adverse Events (II)
• “Serious adverse events” or “withdrawal due to
adverse events … Consider Composite Adverse Events (I)
6. Consider Composite Adverse Events (II)
7.
-
effectivehealthcare.ahrq.gov/products/safety-emerging-methods/executive
September 25, 2007 - Developing Indicators of Inpatient Adverse Drug Events Through Nonlinear Analysis Using Administrative … Real-Time Vaccine Safety Surveillance for the Early Detection of Adverse Events
Tracy A. … Real-Time Vaccine Safety Surveillance for the Early Detection of Adverse Events. … Evaluation and Overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug … Evaluation and overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug
-
effectivehealthcare.ahrq.gov/products/antipsychotics-children/research-protocol
June 04, 2010 - This includes:
Overall adverse events
Specific adverse events
Withdrawals/time to withdrawal due … due to adverse events, persistence and reversibility of adverse events. … events, specific events, withdrawals due to adverse events, time to withdrawal due to adverse events, … Adverse events will be recorded for each intervention group including the description of the adverse … dose-adverse event analysis.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancer-key-questions.pdf
January 01, 2020 - cancer-related mortality,
progression-free survival, quality of life, direct
moderate-severe treatment adverse … events
(grade 3, 4, 5), indirect adverse events from
treatment (i.e., long-term opioid use for pain … cancer-
related mortality, progression-
free survival, QoL, direct
moderate severe treatment
adverse … events, indirect
adverse events from treatment
-
-
-
KQ2: Tx effectiveness vary by cancer
-
effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research
September 25, 2013 - with stent thrombosis (relative risk [RR] = 1.52; 95% confidence interval [CI], 1.17 to 1.97); major adverse … a dominant model, gain-of-function alleles were significantly associated with reduced risk of major adverse … , studies suggested that increased on-clopidogrel reactivity was associated with increased rates of adverse … evidence to support an association between loss-of-function CYP2C19 variants and increased risk of adverse … found evidence that high on clopidogrel platelet reactivity is associated with an increased risk of adverse