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effectivehealthcare.ahrq.gov/sites/default/files/related_files/atypical-antipsychotics-off-label_executive.pdf
January 01, 2007 - What are the potential
adverse effects and/or complications
involved with off-label prescribing of
atypical … Table B
summarizes findings on adverse events and safety. … See “Potential adverse effects
and complications” section. … Potential adverse effects and complications
There is high-quality evidence that olanzapine
patients … The manufacturers
of risperidone pooled four RCTs and found that
cerebrovascular adverse events were
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
June 01, 2018 - stay in hospital
Length of stay in skilled nursing facility
Sitter use
Hospice enrollment
o Adverse … • For outcomes other than adverse
events, we will exclude studies that
do not have a comparison … stay in hospital; length
of stay in skilled nursing facility;
sitter use; hospice enrollment)
o Adverse … • For adverse events, we will include
randomized controlled trials, non-
randomized controlled trials … 11
important for each of the patient groups, with at least 1 outcome being a potential
adverse
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-interventions-maltreatment-child_executive.pdf
April 01, 2013 - KQ 6: What adverse events are associated with
interventions for children exposed to maltreatment (e.g … KQ 6 summarizes the evidence
for the one trial that was identified that addressed adverse
events. … examining adverse events because
there is the potential for harms, even temporary, associated
with … Only two trials reported
an incident that the authors classified as an adverse event. … The Adverse Childhood Experiences (ACE) Study.
Am J Prev Med. 1998 May;14(4):245-58.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/menopause_research-protocol.pdf
March 25, 2012 - What are the significant agent-specific harms/adverse effects of
nonhormone therapies? … Question 4
Does effectiveness and adverse effects vary among subgroups of patients defined by … Also considered are consequential adverse effects among women
using hormone therapies; these adverse … Finally,
adverse events accompanying the use of nonhormone agents are also depicted. … ((((“adverse effects” [Subheading]) OR “complications” [Subheading]) OR ( “poisoning”
[Subheading] OR
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - systemic therapies
may be effective but can be associated with significant
short-term and long-term adverse … Currently, guidelines suggest that clinicians balance
individual patient characteristics with the reported adverse … Health Assessment
Questionnaire Disability Index; HRQoL = health-related quality of life; MACE = major adverse … health outcomes, adequate study duration with
clinically relevant treatment modalities, assessment of
adverse … Adverse events were not evaluated
in these studies.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0277_03-10-2008.pdf
January 01, 2008 - the cost of treatment,
the severity of diseases that HSCT is used to treat, and the prevalence of adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0086_04-01-2009.pdf
January 01, 2009 - any commonly used dietary supplements decrease the
effectiveness of these medications or increase adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - What are the harms, including adverse events,
associated with interventions for management of
postpartum … Also, adverse
events may occur at any point after the intervention is
received.
Figure A. … A fourth review noted more adverse effects related to
misoprostol than placebo. … No serious adverse reactions were attributed to
the study drugs in either RCT but reporting in 1 RCT … Therefore, it is sometimes
hard to know whether to classify transfusion as an adverse
outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
June 12, 2013 - What are the significant agent-specific harms/adverse effects of
nonhormone therapies? … Question 4
Does effectiveness and adverse effects vary among subgroups of patients defined by … Also considered are consequential adverse effects among women
using hormone therapies; these adverse … Finally,
adverse events accompanying the use of nonhormone agents are also depicted. … ((((“adverse effects” [Subheading]) OR “complications” [Subheading]) OR ( “poisoning”
[Subheading] OR
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - Neuroleptic malignant syndrome is a rare but serious adverse effect. … Adverse effects (AEs) will be examined for each condition (KQ2) and across all conditions
(KQ3). … adverse!effects*!!
•! Mortality
•! Cerebrovascular disease-related events
•! … adverse!effects!!
•! Neuromotor effects (e.g., extrapyramidal symptoms! … Adverse!event!outcome!data!for!extraction!in!the!comparative!effectiveness!review!
Adverse!event!
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_executive.pdf
February 01, 2014 - pharmacologic aids may limit
the exposure to tobacco smoke, little is known about
their potential adverse … as well as varenicline and bupropion, are category C
medications, meaning animal studies have shown adverse … Data on harms or
adverse effects of included interventions are captured in
Key Question 3. … None of the studies reported a
higher incidence of adverse events in women receiving
interventions … Smoking and smoking
cessation during early pregnancy and its effect on adverse
pregnancy outcomes and
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
November 13, 2014 - Further, antipsychotic
medications have limited evidence for efficacy and high risk for adverse effects … One can use case series, but they
have no controls and may overestimate the rate of “adverse events” … since the rate of
“adverse events” among persons getting placebos is high.40 One can use case-control … One can examine adverse events with the
intervention in other patient populations, but this does not … Placebo--efficacy and adverse effects in controlled clinical trials.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1506.pdf
October 01, 2015 - The most common
adverse reactions reported in patients treated with pirfenidone included abdominal … patients may require a dose reduction to 100 mg, twice daily, or treatment
interruption to manage adverse … The most common adverse
reactions reported in patients treated with nintedanib included abdominal pain … impact potential, more data demonstrating reductions in transplantation-associated
complications, adverse … However, two clinical experts
stated that adverse events could reduce patient acceptance.58,64 One
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias-individual-studies_methods.pdf
March 01, 2012 - Impugning
the integrity of medical science: the adverse
effects of industry influence. … On reporting:
• Were any patients excluded from the adverse effects analysis? … • Which categories of adverse effects were reported by the investigators? … • Is there a plausible biological mechanism linking the intervention to the adverse event? … Adverse
effects. In: Higgins JPT, Green S, eds.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_disposition-comments.pdf
May 27, 2010 - Older age and
certain therapies for chronic diseases may
increase susceptibility for this adverse effect … of the
challenges of conducting randomized, controlled
trials of IMRT to address non-xerostomia
adverse … of the
challenges of conducting randomized, controlled
trials of IMRT to address non-xerostomia
adverse … Older age and
certain therapies for chronic diseases may
increase susceptibility for this adverse effect … • CTCAE is a broad dictionary of adverse event terms and grades.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - none
• Final outcomes: diagnosis of ovarian cancer, ovarian cancer mortality, overall
mortality
• Adverse … certain short-term (e.g., venous thromboembolism) and long-term (e.g., breast cancer, cervical
cancer) adverse … :
For KQs 1, 2, 3, 6:
o Final outcomes: diagnosis of ovarian cancer, ovarian cancer mortality
o Adverse … cancer, endometriosis,
dysmenorrhea, acne, colorectal cancer, or premenstrual dysphoric
disorder
o Adverse … The safety outcomes will be
framed to help identify adverse events as described in KQ 5.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management-1_research-2007.pdf
January 01, 2007 - events or potential
adverse events. … of medications or on cost-
savings,5, 8, 9 while other programs have focused on reducing potential adverse … Fatal adverse drug events: the paradox of drug
treatment. J Intern Med 2001;250(4):327-41.
19. … Adverse drug events in emergency department
patients. … Role of
pharmacist counseling in preventing adverse drug
events after hospitalization.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
November 01, 2017 - study
and 0.49 percent (1/205) in another study; one study
reported one case of a life-threatening adverse … Although six
studies reported low rates (0 to 1.2%) of death or serious
adverse events among patients … to treatment for opioid use disorder and risk of
future overdose episodes, in addition to serious adverse … were probably at low risk for such events, and there is
insufficient evidence to determine risk of adverse … Adverse events after
naloxone treatment of episodes of suspected acute opioid
overdose.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
December 01, 2014 - What is the comparative effectiveness
of 3DCRT, IMRT, SBRT, and PBT regarding adverse
events and QOL … Outcomes
Outcomes for Key Questions 1, 3, and 4 included—
• Final outcomes: QOL and adverse events, … Criteria for Adverse
Events) is necessary to permit accurate assessment of
the relative benefits and … In
particular, given the evidence summarized in this report,
we recognize dysphagia as a key adverse … Evidence was insufficient to draw relative conclusions on
survival or tumor control; adverse events
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ischemic-stroke-treatment_research-protocol.pdf
February 19, 2010 - Outcomes: The outcomes are broken up into adverse events (e.g., failure to deploy the device or
remove … Adverse events, harms and safety issues reported
Question 3:
What are the variables associated with … The outcomes
are broken up into adverse events, intermediate outcomes, and final health outcomes. … The
adverse events of note include failure of the device to employ, breakage or fracture, perforation … outcomes
Mortality
mRS
NIHSS
Barthel Index
GOS
Patients with
Acute
Ischemic
Stroke
Adverse