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Total Results: 1,402 records

Showing results for "adverse".

441. Research Protocol for Interventions for Substance Use Disorders in Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/suda-final-protocol.pdf
     October 02, 2018 - majority were untreated.1 Adolescents with SUD are at risk of experiencing a cascade of far-reaching adverse … How do benefits and adverse outcomes of interventions vary by subpopulations?2 b. … How do benefits and adverse outcomes of interventions vary by intervention characteristics? … How do comparative benefits and adverse outcomes of interventions vary by subpopulations? 2 b. … How do comparative benefits and adverse outcomes of interventions vary by intervention characteristics

442. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-218-osteoporosis-disposition-comments.pdf
     April 23, 2019 - Fractures w ere not prespecif ied as an outcome and w ere captured via routine adverse event reporting … Statements about the risk of potential adverse drug reactions are made without the rigor that is applied … In a clinical trial all adverse events are collected without regard to the investigator’s assessment … is associated with a higher (harm) or lower (benefit) risk of a specific adverse event. … Evidence on fracture incidence, change in bone mineral density (BMD), and adverse events over up to

443. Topic-Brief2-Opioid-Withdrawal (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief2-opioid-withdrawal.pdf
     April 01, 2021 - Patients may experience withdrawal symptoms, negative psychological effects, worsened pain, or serious adverse … population could improve symptoms and increase the likelihood of tapering success, while reducing adverse … opioid therapy is associated with reduced pain intensity in some patients, it is also associated with adverse … function, quality of life, mental health outcomes, opioid dose, likelihood of opioid discontinuation, adverse … challenge for clinicians and patients and can be associated with negative clinical outcomes and adverse

444. Topic-Brief2-Opioid-Withdrawal (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief2-opioid-withdrawal.pdf
     April 01, 2021 - Patients may experience withdrawal symptoms, negative psychological effects, worsened pain, or serious adverse … population could improve symptoms and increase the likelihood of tapering success, while reducing adverse … opioid therapy is associated with reduced pain intensity in some patients, it is also associated with adverse … function, quality of life, mental health outcomes, opioid dose, likelihood of opioid discontinuation, adverse … challenge for clinicians and patients and can be associated with negative clinical outcomes and adverse

445. Evidence Summary_Comparative Effectiveness Review No. 247_Interventional Treatments for Acute and Chronic Pain: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-247-interventional-treatments-acute-chronic-pain-evidence-summary_0.pdf
     September 01, 2021 - Observational studies were eligible for assessment of rare, serious adverse events. … risk of incident vertebral fracture at 12 months and longer (7 trials, N=826); evidence on serious adverse … imprecise but did not indicate increased risk (SOE: moderate for vertebral fracture, low for serious adverse … between intradiscal platelet-rich plasma injection and saline injection in harms, including no serious adverse

446. head-neck-cancer-update-140204 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
     February 04, 2014 - any of these modalities is more effective than the others: 1) in reducing normal tissue toxicity and adverse … Evidence was insufficient to draw relative conclusions on survival or tumor control; adverse events … Other tools used to assess adverse events include the Subjective, Objective, Management, Analytic (SOMA … A quest to improve upon survival rates and the adverse effect profile of conventional 2DRT has led to … Key Question 1 What is the comparative effectiveness of 3DRT, IMRT, SBRT, and PBRT regarding adverse

447. S1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s1.pdf
     October 01, 2007 - expanded access and use of drug therapies also holds the potential for poor outcomes resulting from the adverse … Furthermore, premarketing studies are generally not designed to evaluate multiple endpoints, detect rare adverse

448. Tx-For-Localized-Prostate-Cancer Surveillanceassesment 20120614 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
     May 01, 2012 - All treatment options result in adverse effects (primarily urinary, bowel, and sexual), although the … Even if differences in therapeutic effectiveness exist, differences in adverse effects, convenience … Results from 1 study (Barry) did not show fewer adverse effects following robotic prostatectomy. … Even if differences in therapeutic effectiveness exist, differences in adverse effects, convenience … Do Not Know and adverse effects. Additional randomized controlled trials (RCTs) are needed.

449. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
     October 01, 2015 - The most common adverse reactions occurring in patients treated with pirfenidone compared with placebo … patients may require a dose reduction to 100 mg, twice daily, or treatment interruption to manage adverse … The most common adverse reactions occurring in patients treated with nintedanib compared with placebo … impact potential, more data demonstrating reductions in transplantation-associated complications, adverse … However, two clinical experts stated that adverse events could reduce patient acceptance.41,47 One

450. Tx-For-Localized-Prostate-Cancer Surveillanceassesment 20120614 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/tx-for-localized-prostate-cancer_surveillanceassesment_20120614.pdf
     May 01, 2012 - All treatment options result in adverse effects (primarily urinary, bowel, and sexual), although the … Even if differences in therapeutic effectiveness exist, differences in adverse effects, convenience … Results from 1 study (Barry) did not show fewer adverse effects following robotic prostatectomy. … Even if differences in therapeutic effectiveness exist, differences in adverse effects, convenience … Do Not Know and adverse effects. Additional randomized controlled trials (RCTs) are needed.

451. TND-0775-150722 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0775-150722.pdf
     May 12, 2015 - . § Common adverse effects of many antipsychotics used for schizophrenia include: weight gain, diabetes … disorder, with a focus on core illness symptoms, functional outcomes, health care system utilization, and adverse

452. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ptsd-adult-treatment_research-protocol.pdf
     December 20, 2011 - Question 6: What adverse effects are associated with treatments for adults diagnosed with PTSD? … quality of life ○ Disability/functional impairment ○ Return to work/return to active duty ○ Adverse … events: overall adverse events, withdrawals due to adverse events, and specific adverse events (including … KQ 6 looks as the adverse effects of these interventions. … effects), we will evaluate the trials included in KQs 1 through 4 that report adverse effects.

453. Pressure-Ulcer-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-treatment_executive.pdf
     May 01, 2013 - Variability in study populations, interventions, adverse event measurement, and reporting precluded … an estimate of adverse event rates for dressings and topical therapies (30 studies). … Light therapy Low Light therapy caused no significant adverse events based on 4 randomized studies ( … Harms: Adjunctive Electrical stimulation Low Frail elderly patients experienced more adverse events … However, variability across studies precluded an estimate of adverse events for specific dressings

454. Effectiveness of Treatments for Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetic-neuropathy_research-protocol.pdf
     May 09, 2016 - • Harms (KQ2a and KQ2b): Adverse effects reported in >10% of patients and all dropouts [10% is generally … considered a threshold for common adverse effects. … Adverse effects over 10% are reported in the studies and compiled in systematic reviews. … Serious adverse effects (including death) are reported as dropouts due to adverse effects]. … effects Adverse effects reported in >10% of patients and dropouts (KQ 2 and KQ2b) Treatment

455. Critical Analysis of the Evidence for Patient Safety Practices in Nursing Home Settings (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nursing-home-safety_research-protocol.pdf
     July 22, 2015 - defines safety as “a type of process or structure whose application reduces the probability of an adverse … acquired infection (HAI) and urinary tract infection, excessive weight loss, medication error and adverse … acquired infection (HAI) and urinary tract infection, excessive weight loss, medication error and adverse … Thus, the outcomes targeted for prevention are often the same: falls, pressure ulcers, delirium and adverse … Medication error and adverse drug events Common Format/ Nursing Home Compare QI Medication management

456. Nephropathy-Contrast-Induced Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/nephropathy-contrast-induced_executive-2016.pdf
     January 01, 2016 - such as need for renal replacement therapy (including dialysis or hemofiltration), cardiac outcomes, adverse … Food and Drug Administration Adverse Event Reporting System (AERS). … data on cardiac outcomes, need for renal replacement therapy, mortality, length of hospital stay, adverse … For less frequent adverse outcomes, we used an optimum information size of 10,000, based on an expected … renal replacement therapy (5 studies), cardiovascular outcomes (7 studies), mortality (8 studies), adverse

457. Peripheral-Artery-Disease-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/peripheral-artery-disease-treatment_research-protocol.pdf
     January 31, 2013 - What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug … What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug … What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug … The safety outcomes will be framed to help identify adverse events, including adverse drug reactions … What are the significant safety concerns associated with each treatment strategy (e.g., adverse drug

458. Medication-Therapy-Management Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
     November 01, 2014 - Too often, however, medications are not used appropriately.1-3 In the United States in 2001, adverse … drug events led to an estimated 4.3 million ambulatory visits.4 In addition to problems involving adverse … 20 percent were taking 10 or more medications,8 placing them at increased risk for experiencing adverse … Similarly, we did not have evidence of benefit for most patient-centered outcomes, including adverse … Ambulatory care visits for treating adverse drug effects in the United States, 1995-2001.

459. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - comparison:  Hospital-based infections and other harms o Antibiotics comparisons:  Side effects/adverse … difficile (C diff) infection  Antibiotic resistance o Interventional radiology comparisons:  Adverse … o N≥30/arm* • Single group studies o Only for adverse events o N>100† • Longitudinal (Exclude: … cancer mortality • Tolerance, feasibility, and completion of procedure; technical adequacy • Harms, adverse … † Restricting to larger studies will allow estimates of adverse event rates to be increasingly precise

460. Obesity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - Research indicates that individuals can reduce their risk of obesity-related adverse health conditions … While several experts mentioned the uncertainty of long- term adverse events as a potential barrier … Adverse events were reported in 100% of patients in this study. … However, multiple experts also noted the significant reported side effects and adverse events and the … discontinuation rate, which they believe to be significant adverse factors.