-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-pregnancy-postpartum_research-protocol.pdf
March 29, 2013 - risk
of suicide, each of which compromises the health of both the woman and her fetus.5,6 Several
adverse … Framework
The analytic framework below illustrates the population, interventions, outcomes, and
adverse … reports
• Withdrawals from study and discontinuation of treatment due to adverse events
Source: … events associated with discontinuation of treatment
• Serious adverse events reported
Fetus, Infant … Maternal antidepressant use and adverse outcomes:
a cohort study of 228,876 pregnancies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
August 05, 2010 - • Adverse events will be evaluated from studies of the drugs used for
osteoarthritis, rheumatoid … Also, adverse events may
occur at any point after the treatment is received.
IV. Methods
A. … We assumed that the adverse events occurred independently and
that the logarithm of the rate ratios … , we
estimated the net effects on all three serious adverse events using Monte Carlo
simulation. … We also pooled clinical success rates and withdrawal due to adverse events from head-
to-head trials
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-tables-e1-4.xlsx
January 01, 2025 - Adverse Events
Table E-4. … Any Adverse Event Intervention B, N of Any Adverse Event (Numerator) Intervention B, N Analyzed for … Any Adverse Event (Denominator) Intervention B, % With Any Adverse Event Intervention C, N of Any Adverse … With Any Adverse Event Intervention D, N of Any Adverse Event (Numerator) Intervention D, N Analyzed … A, % With Serious Adverse Event Intervention B, N of Serious Adverse Event (Numerator) Intervention
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - events is
critically important
The specific adverse events that were selected
for this report, and … The specific adverse events that were selected
for this report, and were graded (implying a
higher … adverse events but those reported to be
severe by the individual trials. … an adverse event in the trial,
regardless of what that adverse event was. … The
outcomes are defined (including “any adverse
event” in the methods chapter).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-choosing-outcomes.ppt
June 01, 2012 - Example 1: High false-positive rates in screening tests (e.g., mammography) make adverse emotional effects … The key questions in the review focused on the reduction in adverse pregnancy outcomes and the adverse … Clinical Management Effects
Included in the systematic review:
Does screening reduce adverse pregnancy … Specifically, they included the adverse effects of therapies and the benefits of reducing adverse pregnancy … The test itself may result in adverse effects that must be treated and, therefore. generate a cost.
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-choosing-outcomes.ppt
June 01, 2012 - Example 1: High false-positive rates in screening tests (e.g., mammography) make adverse emotional effects … The key questions in the review focused on the reduction in adverse pregnancy outcomes and the adverse … Clinical Management Effects
Included in the systematic review:
Does screening reduce adverse pregnancy … Specifically, they included the adverse effects of therapies and the benefits of reducing adverse pregnancy … The test itself may result in adverse effects that must be treated and, therefore. generate a cost.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-artery-stenosis_research-2007.pdf
January 01, 2007 - What adverse events and complications have been associated with aggressive medical
therapy or renal … Adverse events (including 30 day mortality)
No new data on adverse event rates among comparative studies … Adverse events (including 30 day mortality)
A total of 22 studies reported adverse events immediately … , though serious long-term adverse events were rare. … Reported adverse events from antihypertensives were relatively minor and
transient.
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
June 01, 2014 - However, experts noted that patients would likely be concerned about potential adverse
events. … The researchers also reported that the most common adverse
events “included headache (35%), nausea … The most commonly reported (≥10%) adverse reactions in patients treated…across all
clinical studies … Of subjects receiving the recommended dose of 0.05
mg/kg/day, 88.3% (n=68/77) experienced an adverse … Many of these adverse reactions were reported in association with the underlying
disease and/or use
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
December 01, 2014 - However, experts
noted that patients would likely be concerned about potential adverse events. … The researchers also reported that the most common adverse
events “included headache (35%), nausea … The most commonly reported (≥10%) adverse reactions in patients treated…across all
clinical studies … Of subjects receiving the recommended dose of 0.05
mg/kg/day, 88.3% (n=68/77) experienced an adverse … Many of these adverse reactions were reported in association with the underlying
disease and/or use
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-addendum-app.xlsx
May 29, 2025 - Outcome Measures Duration of Follow-Up Results - Primary Outcomes Results - Secondary Outcomes Harms and Adverse … See above
Addendum Appendix Abbreviations
Abbreviations for Addendum Appendix
Acronym Term
AE adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
August 01, 2022 - No significant adverse
events were reported. … No serious adverse events or withdrawal due to adverse
events were reported. … No serious adverse events
were observed. … No
serious adverse events, death, and withdrawal due to
adverse events were reported. … No
patients reported adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_research-protocol.pdf
November 24, 2014 - Although most adverse effects are minor, such as constipation, diarrhea, and dizziness,
they frequently … events (safety and tolerability): overall adverse events, withdrawals
because of adverse events, serious … adverse events, specific adverse events
(including hyponatremia, seizures, suicidality, hepatotoxicity … , weight gain,
gastrointestinal symptoms, sexual side effects), withdrawals because of
specific adverse … events, results, and adverse events
reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
November 30, 2011 - dosages and durations of treatment according to
various factors.
10
A common (50 to 60 percent) adverse … In addition, psychiatric,
gastrointestinal, dermatological, and hematologic adverse effects underlie … , hepatic cirrhosis,
hepatocellular carcinoma, and liver transplants
Transmission of HCV
Adverse … effects of intervention(s)
Harms from antiviral treatment, including withdrawals due to adverse … events, serious
adverse events such as severe neutropenia, psychological adverse events, flu-like
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
November 01, 2023 - Collection of adverse events data was notably inconsistent
across studies. … In particular, although some studies reported all adverse events, others
only reported them in the situation … Trials of topiramate
reported increased risks of many adverse events, including paresthesias, taste … For most serious harms, there was insufficient data to
determine comparative rates of adverse events
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - Given the availability of alternative treatments and concern
about adverse clinical outcomes in clopidogrel … events and liver toxicity)
o Adverse effects of testing per se (including test-related anxiety and … adverse
events secondary to venipuncture) … effects
of test-directed
treatment
KQ 1c, 2c, 3b
KQ4
KQ4
Adverse effects of
genetic testing … Adverse effects of
phenotypic testing
KQ4
KQ4
Patients with
cardiovascular,
cerebrovascular
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
June 01, 2017 - Secondary
Adverse events, otoscopic exams, audiometry, and tympanometry
Microbiological response … In general, there were few serious adverse events and many other
adverse events. … showed more adverse events in the intervention group. … events, including serious adverse events (not defined), other
adverse events (not defined), and acute … Question 3: What adverse events, surgical complications, and sequelae are associated with
inserting
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
September 22, 2014 - improved appropriate antibiotic use is expected to have other benefits,
particularly a reduction in adverse … Key Question 5: What are the comparative non-clinical adverse effects of strategies for
improving the … Key Question 2
• Mortality
• Antibiotic resistance
• Medical complications
• Adverse drug effects … Adverse!drug!
effects)!
KQ3:#
! Time!to!return!to!work/!
school!
! Clinic/ED!visits,!admission! … Adverse!effects!
of!the!strategy!
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
August 31, 2017 - This is particularly a problem for rare
adverse events. … By including
observational studies, we capture a
better assessment of adverse
effects. … Peer Reviewer # 3
Methods Adverse event reporting. … For withdrawals, we reported overall
withdrawals and withdrawals due to
adverse events. … The adverse effects were minor for
the most part.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_executive.pdf
August 01, 2016 - Adverse events:
• What adverse effects are related to n-3 FA intake
(in studies of CVD outcomes and … study arms, and no serious or
severe adverse event was attributed to n-3 FA. … Six of the
marine oil trials explicit stated that most or all adverse
events were mild. … • No serious or severe adverse events were related
to n-3 FA intake (supplementation). … differences in serious or nonserious adverse events
between marine oil and placebo.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
October 07, 2011 - We would like to suggest that the researchers
consider consulting other data sources such as adverse … Conceivably, information from adverse event databases
would support the clinical impression that the … The purpose of this section is to describe the
potential adverse events that may be
encountered in … Aside from the risk itself, the emergence of a new
adverse event from an outside meta-analysis raises … adverse event rates but no more
benefit than a single drug.