-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
March 01, 2012 - The update search identified new data on effectiveness
and adverse effects. … were included in the adverse event analysis … included
information on the relationship between the adverse event
and the drug. … of all adverse events
that were reported for any of the drugs. … • Adverse effects—and concerns about adverse effects—
appear to be important predictors of adherence
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_executive.pdf
June 01, 2013 - Adverse Effects With Off-Label Pharmacologic Agents:
Antiepileptic Drugs
Topiramate. … Rates
of adverse effects did not differ among 50, 100, and
200 mg/day of topiramate. … , and 17 percent discontinued treatment due to
bothersome adverse effects. … Evaluation and
registration of adverse events in clinical drug trials in migraine. … Adverse drug
reactions and off-label drug use in paediatric outpatients.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_executive.pdf
May 01, 2010 - What is the comparative effectiveness of IMRT,
3DCRT, 2DRT, and proton beam therapy regarding
adverse … evidence is insufficient to draw
conclusions about the comparative effects of IMRT
and 3DCRT for other adverse … evidence is insufficient to draw
conclusions about the comparative effects of IMRT
and 2DRT for other adverse … As a result, the patient may be at risk of
greater adverse effects from an inadvertently high dose
to … Older age and certain therapies for chronic
diseases may increase susceptibility for this adverse
effect
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_clinician.pdf
July 01, 2016 - This is a summary of a systematic review evaluating the evidence regarding the potential benefits and adverse … Noninvasive nonsurgical fecal incontinence treatments
had few minor adverse effects. … Overview of Clinical Research Evidence (Continued)
Table 2: Adverse Effects Associated With Interventions … Longer term information on benefits and
adverse effects would better inform clinical decisions for … Substantial and life-
altering adverse events sometimes occur after surgery for
fecal incontinence,
-
effectivehealthcare.ahrq.gov/sites/default/files/s81.pdf
October 01, 2007 - ORIGINAL ARTICLE
Developing Indicators of Inpatient Adverse Drug Events
Through Nonlinear Analysis Using … : Because of uniform availability, hospital administra-
tive data are appealing for surveillance of adverse … Up to 5 adverse events were
evaluated for each admission. … These
fields included adverse event codes. … High rates of adverse drug
events in a highly computerized hospital.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
October 01, 2022 - However, treating seizures may
have adverse effects that could also contribute to delayed development … We concluded that
for three medications (levetiracetam, topiramate, and lamotrigine) adverse effects … For topiramate, we found consistent evidence of
dose-response effects for two non-severe adverse effects … For dietary treatments, evidence on adverse
effects was insufficient to permit conclusions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-executive-summary-2023-update.pdf
January 01, 2023 - There may be no increase in risk of serious adverse events (strength of evidence
[SOE]: low) or withdrawal … due to adverse events. … • Other key adverse event outcomes (psychosis, cannabis use disorder, cognitive
deficits) and outcomes … Other prioritized adverse
events (cannabis use disorder [CUD], psychosis, cognitive deficits) and the … event; SOE = strength of
evidence; THC = tetrahydrocannabinol; WAE = withdrawal due to adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-263-postpartum-hypertensive-pregnancy-executive-summary.pdf
May 01, 2023 - that evaluated different drugs), length of postpartum
hospital stay (reported in only one study), and adverse … studies that addressed
quality of life, psychosocial distress, reduction in health disparities, or adverse … ambulation), maternal-neonatal bonding,
psychosocial distress, reduction in health disparities, or adverse … Further evidence is needed to determine whether HBPM can
reduce the occurrence of adverse clinical outcomes … ✓
Lower dose MgSO4 regimen
lowers the risk of
magnesium toxicity
Other clinically
important adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-table-E-5.xlsx
January 01, 2023 - Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. NR, RR for A vs. … B 0.72 (95% CI 0.49 to 1.07)
Serious adverse events: none in any group
Withdrawals due to adverse events … C
Any adverse event: 26.1% (91/348) vs. 14.9% (56/377); adjusted OR 1.00 (95% CI 0.64 to 1.58) NR No … adverse events: 13% (28/215) vs. 19.4% (42/216), RR 0.67 (95% CI 0.43 to 1.04)
Withdrawals due to adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-table-F5.xlsx
January 01, 2022 - Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid Use Outcomes Adverse … C
% (n/N)
Any adverse event
3 months: 35% (19/49) vs. 47% (30/52) vs. NR, RR for A vs. … B 0.72 (95% CI 0.49 to 1.07)
Serious adverse events: none in any group
Withdrawals due to adverse events … C
Any adverse event: 26.1% (91/348) vs. 14.9% (56/377); adjusted OR 1.00 (95% CI 0.64 to 1.58) NR No … adverse events: 13% (28/215) vs. 19.4% (42/216), RR 0.67 (95% CI 0.43 to 1.04)
Withdrawals due to adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
March 01, 2024 - • The identified diagnostic studies did not assess the adverse effects of being
labeled correctly … significant differences
between stimulant and non-stimulant medications for most effectiveness outcomes
and adverse … Furthermore, the identified studies did not assess the adverse effects of being labeled
correctly or … effectiveness outcomes, such
as ADHD symptoms (SMD 0.23; CI -0.03, 0.49; 7 studies, n=1611; low SoE) and
adverse … Across studies, medication therapy evaluations reported more adverse events
than non-medication interventions
-
effectivehealthcare.ahrq.gov/products/depression-harms/research-protocol
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief1-care-coordination.pdf
April 01, 2021 - disruptions in pain management, which could result in worsened quality of life,
function, and other adverse … persons with pain are often discharged
on opioids; such patients may be at risk for opioid-related adverse … transitional
care interventions represent a potential opportunity to optimize management and reduce adverse … entitled to Medicare with pain represent a potential opportunity to
optimize management and reduce adverse … 1
Outcomes Pain, function, quality of life, readmission, pain
management (including opioid use), adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief1-care-coordination.pdf
April 01, 2021 - disruptions in pain management, which could result in worsened quality of life,
function, and other adverse … persons with pain are often discharged
on opioids; such patients may be at risk for opioid-related adverse … transitional
care interventions represent a potential opportunity to optimize management and reduce adverse … entitled to Medicare with pain represent a potential opportunity to
optimize management and reduce adverse … 1
Outcomes Pain, function, quality of life, readmission, pain
management (including opioid use), adverse
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-finding-evidence_methods.pdf
January 01, 2011 - Effect Methods Group57
and other experts.58,59
Adverse Effects/Harms
A search for adverse effects … Systematic reviews of adverse effects:
framework for a structured approach. … Including adverse effects. In: Higgins
JP, Green S, eds. … A survey of the methods used
in systematic reviews of adverse effects. … Golder 2006 Adverse Effects
search approach MEDLINE EMBASE
specified adverse effects Drug terms AND
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
January 01, 2025 - that have potential
analgesic effects as well as the potential for addiction, misuse, and serious adverse … There may be no increase in
risk of serious adverse events (SOE: low) or withdrawal due to adverse events … • Other key adverse event outcomes (psychosis, cannabis use disorder, cognitive
deficits) and outcomes … Other prioritized adverse
events (cannabis use disorder [CUD], psychosis, cognitive deficits) and the … event; SOE = strength of evidence; THC =
tetrahydrocannabinol; WAE = withdrawal due to adverse event
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - No
serious adverse events were
observed. … There were no treatment-
related adverse events. … and withdrawals due to adverse events compared with placebo. … No serious adverse events
were observed. … No treatment related adverse events were
reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol-amendment.pdf
November 26, 2024 - cognitive impairment, and
substance use disorders.10 This project will investigate the epidemiology and adverse … term")) OR (title: ("long term")) OR (title: ("longer
term")) OR (title: (outcomes)) OR (title: ("adverse … event")) OR (title: ("adverse
events")) OR (title: (consequence)) OR (title: (consequences)) OR (title … (abstract: ("long term")) OR (abstract: ("longer term")) OR (abstract:
(outcomes)) OR (abstract: ("adverse … event")) OR (abstract: ("adverse
events")) OR (abstract: (consequence)) OR (abstract: (consequences
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
November 01, 2009 - Four reviewers identified studies of any
design describing clinical outcomes or
adverse events with 10 … of four reviewers
extracted study, patient, and treatment
characteristics; clinical outcomes;
and adverse … Seventy-five percent of studies (188) reported the
adverse events. … Not all studies adopted established
scales to evaluate adverse events. … However, it was not clear whether the reported adverse
events were exclusively attributable to charged
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - All treatment options result in adverse
effects (primarily urinary, bowel, and sexual), although
the … Even if differences in therapeutic
effectiveness exist, differences in adverse effects,
convenience, … Data from
nonrandomized trials are inadequate to reliably assess
comparative effectiveness and adverse … Adverse effects were reported, but definitions and
severity varied widely. … effects of Medium • Adverse event definitions and severity varied widely.