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effectivehealthcare-admin.ahrq.gov/products/anxiety-children/research-2017
January 01, 2020 - based on all three reporters (child, parent, and clinician) and are more likely to cause short-term adverse … Long-term adverse events require further study. … the components of cognitive behavioral therapy, compare drugs head to head, and study the long-term adverse … Medications increased short-term adverse events that were mostly not serious (low or moderate SOE). … primarily those targeting serotonin, are also effective and were associated with various short-term adverse
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effectivehealthcare-admin.ahrq.gov/products/weight-loss-surgery/research
December 01, 2019 - The following studies were excluded: (1) those with no outcomes of efficacy, effectiveness, or safety/adverse … Short-term rates of adverse events associated with bariatric surgery were relatively low. … long-term studies of bariatric surgery in this particular target population, few data exist about long-term adverse … Short-term adverse events are relatively minor; strength of evidence is low due to small sample size … Strength of evidence is insufficient regarding adverse events in the long-term (2 years or more postsurgery
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effectivehealthcare-admin.ahrq.gov/products/ace-inhibitor-arb-update/research-protocol
December 01, 2019 - event rates, overall adverse event rates, and withdrawals due to adverse events, withdrawal rates, switch … rates)
Specific adverse events (including, but not limited to, weight gain, impaired renal function … Also, adverse events (including, but not limited to, weight gain, impaired renal function, angioedema … events, withdrawals due to adverse events, serious adverse events reported, withdrawal rates, switch … rates)
Specific adverse events , including but not limited to weight gain, impaired renal function
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - This includes:
• Overall adverse events.
• Specific adverse events. … • Withdrawals and time to withdrawal due to adverse
events. … • Persistence and reversibility of adverse events.
3. … Twelve studies provided adverse-events data for FGAs
versus SGAs. … Adverse events were reported in 36 studies comparing
SGAs with placebo.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-200-post-acs-depression.pdf
November 01, 2017 - effects
• Depression-related outcomes
–
–
•
•
Adverse effects of treatments
Weight … effects 1 study RCT Unknown Imprecisea No difference,
findings not
reported by
specific adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; HR=hazard ratio; MACE=major adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; HR=hazard ratio; MACE=major adverse … Abbreviations: BDI=Beck Depression Inventory; CI=confidence interval; MACE=major adverse cardiovascular
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/insomnia_clinician.pdf
August 01, 2017 - review that evaluated current evidence regarding the effectiveness, comparative effectiveness,
and adverse … The systematic review assessed the efficacy, comparative
effectiveness, and adverse effects of a broad … Psychological and Behavioral Therapy: Adverse Effects
�� Evidence was insufficient regarding the adverse … Pharmacological Therapy: Adverse Effects (See Table 3)
�� Evidence regarding the long-term (more than … and
fractures, head injuries, dementia, and cancer.
�� FDA labels warn of several potential severe adverse
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glucocorticoid-injections_clinician.pdf
June 01, 2016 - Brief Summary
of Findings for Clinicians
KEY CLINICAL ISSUE
What are the relative effectiveness and adverse … This trial also sought
to compare the adverse effects of epidural
injections of glucocorticoids plus … There were no differences be-
tween injection approaches at 6 weeks.
»» There were more reported adverse … Serious adverse events (hospitalization
or surgery) were rare among all patients.
»» There were higher … Furthermore, the potential adverse effects of systemic glucocor-
ticoids (e.g., elevated blood glucose
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
March 01, 2022 - Serious adverse events are more common
in patients who received lasmiditan than placebo. … Evidence is insufficient to draw
conclusions about serious adverse events. … Evidence is insufficient to draw
conclusions about serious adverse events. … pharmacologic therapy for acute pain, including any
adverse event, study withdrawal due to adverse … Large
increases in withdrawal due to adverse events were
seen with oxcarbazepine.
-
effectivehealthcare-admin.ahrq.gov/products/ambulatory-safety/technical-brief
January 01, 2020 - in ambulatory settings, the patient safety movement originated in, and has been mainly focused on, adverse … found a moderate number of published intervention evaluations for e-prescribing, medication errors and adverse … Communication for Safe Care Transitions
Rapid Evidence Product
Jan 16, 2024
Reducing Adverse
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
May 07, 2010 - event rates, overall adverse event
rates, and withdrawals due to adverse events, withdrawal rates, … switch
rates)
o Specific adverse events (including, but not limited to, weight gain,
impaired renal … events
•Withdrawals due to adverse events
•Serious adverse events reported
•Withdrawal rates
•Switch … Also, adverse
events (including, but not limited to, weight gain, impaired renal function, angioedema … events, withdrawals due to adverse events, serious adverse events
reported, withdrawal rates, switch
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - Adverse effects of interest include
but are not limited to nausea, diarrhea, headache, tremor, daytime … Also,
adverse events may occur at any point after the treatment is received. … Also, adverse events may occur at any
point after the treatment is received.
IV. … events
Withdrawals because of
adverse events
Discontinuation rates because
of adverse events … Serious adverse events
Specific adverse events or
withdrawals because of specific
adverse events
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effectivehealthcare-admin.ahrq.gov/products/headaches-pregnancy/protocol
May 01, 2020 - Adverse events:
Maternal:
Serious maternal adverse events:*
"Serious" adverse events ( … /infant:
Serious fetal/infant adverse events:*
"Serious" adverse events (including those that … Adverse events:
Maternal:
Serious maternal adverse events:*
"Serious" adverse events ( … /infant:
Serious fetal/infant adverse events:*
"Serious" adverse events (including those that … ) due to neonatal/infant adverse events.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
December 01, 2010 - Outcomes: Disorder-specific and -nonspecific adverse events:
1) Overall adverse events.
2) Specific … adverse events:
a. … withdrawal because of adverse events, and
persistence and reversibility of adverse events … For questions about adverse effects, we will search the U.S. … a dose-
related adverse-event analysis.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
June 01, 2016 - Propranolol was associated with short-term (<6 months)
adverse effects such as hypotension, hypoglycemia … Minor adverse effects such as cold extremities, diarrhea, rash, and sleep
changes were also reported … .
���
Timolol (topical) Adverse effects 4 353 No adverse effects were observed. ���
STEROIDS
All … steroids Adverse effects 16 3291 Steroids were associated with clinically important adverse effects, … effects associated
with the different interventions for IH
��Potential long-term adverse effects
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - Adverse events 22 Low 1 fair trial: no significant differences in
ECT + rTMS specific adverse events … VNS vs. sham Adverse events 235 Low 1 fair trial: Some differences in specific
adverse events reported … Safety, Adverse Events, and Adherence
(KQ 4)
Direct evidence. … Specific adverse events. … More careful and consistent assessment of adverse
events is required.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
January 01, 2007 - To date, no study has evaluated proximal
clinical measures, long-term effects, and adverse events
among … Gastrointestinal adverse events/problems. … Metformin monotherapy was associated
with more frequent adverse events compared with the
combination … , and consistently report all adverse
events (not using aggregated events). … medications in withdrawals due to unspecified adverse events.
events
4&5k.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
March 01, 2011 - Key Question 3: Adverse Events and Side Effects
This Key Question was addressed by 107 studies. … Other adverse events. … Some adverse effects, such as
congestive heart failure, may take years to develop, and
others, such as … We recommend improvements in adverse event
and long-term outcome reporting, with predefined
outcomes … High The rates of GI adverse effects were similar for thiazolidinediones and
sulfonylureas.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/gout_clinician.pdf
January 01, 2017 - = randomized controlled trial; SOE = strength of evidence;
ULT = urate-lowering therapy
Table 4: Adverse … �� Gastrointestinal symptoms, fatigue, and headache
�� Rare adverse effects include leukopenia, aplastic … effects include bone marrow suppression, aseptic meningitis, and dermatological adverse events
�� Serious … adverse effects include gastrointestinal perforations, ulcers, and increased risk of heart attack or … with the various treatment
strategies
��The role of ULT in patients with gout and the potential
adverse
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effectivehealthcare-admin.ahrq.gov/products/schizophrenia-adult/research-2017
February 01, 2018 - Haloperidol had similar benefits but more adverse events than olanzapine and risperidone. … Older SGAs were similar in measures of function, quality of life, mortality, and overall adverse events … Risperidone LAI and olanzapine had less withdrawal due to adverse events. … core illness symptoms, negative symptoms, symptom response, and remission but greater incidence of adverse … Older SGAs were similar to haloperidol on benefit outcomes but had fewer adverse event outcomes.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - events (frequency of any adverse events reported in trials)
• Withdrawals due to adverse events, time … • Significant (major) adverse events
Key Question 2:
• Overall adverse events (frequency of any adverse … events reported int rials)
• Withdrawals due to adverse events, time to withdrawal due to adverse events … Given the variation in specific adverse event profiles
across the SGAs, withdrawals due to adverse events … and ziprasidone
Withdrawal Due to
Adverse Events
• Withdrawals due to adverse
events were significantly