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  1. effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_autism_potential_high_impact_june_2012.pdf
    January 01, 2012 - treatments, screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … The system is intended to identify interventions that purport to address an unmet need and are up to … complementary and unlikely to have as significant an impact on autism treatment as interventions that address … the efficacy of these treatments is unpredictable and varies widely, and when they do work, they address … developing new pharmacotherapies (e.g., enzyme therapies) intended to enhance protein digestion and address
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_disposition-comments.pdf
    March 01, 2012 - Thank you, we have changed the statement to address this comment. … It is difficult to address this comment without additional specificity. … The CER as written addresses this, however, the main issue is that for many important etiologies, the … Yet, the draft AHRQ document addresses epilepsy and its treatment with AEDs as a monolithic and homogeneous … Thus, these studies are inappropriate to address the ‘key questions’ posed in the AHRQ report.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_executive.pdf
    October 01, 2012 - We analyzed studies to address how different types of quality improvement interventions can improve … Table does not address KQ1b; some targets did not have any hospice or nursing home studies, and none
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disabilities-quality-improvement-outcomes_disposition-comments.pdf
    October 15, 2012 - Peer Reviewer #2 General The article address an exceptionally important topic; i.e. measures that … However, as the authors note, the literature search to address the key question was not sufficiently … Although it addresses an important point it also undermines an important medical goal i.e. avoiding … The recovery choice pathways appears to address disability treatment, which is outside the scope of … However, we did note in the discussion section that the ICF is not sufficient to address all individual
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_executive.pdf
    January 01, 2012 - Using these parameters, Key Questions were developed to address the questions of interest. … Key Question 3: Different SMBP Devices Insufficient • No eligible study provided data to address … Relationship With Clinical and Surrogate Outcomes Insufficient • No eligible study provided data to address
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_disposition-comments.pdf
    May 04, 2013 - We address individual comments. … Peer Reviewer #7 General Never addresses why it is important to treat OME – why is it important to … Peer Reviewer #7 Executive Summary Never addresses why it is important to treat OME – why is it … Peer Reviewer #5 Results KQ1: The document doesn’t address the part of the key question regarding … nontreatments make no difference in the long run doesn’t adequately address the important issue.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
    August 23, 2012 - We address this in the discussion chapter. … We think this is important to address any concerns regarding conflict of interest. … Key Question 2 addresses the issue of nitrous oxide's impact on women's satisfaction. … We did not find any studies that address the issue of abuse. … There are 5 questions, but there was no literature to address Key Question 5.
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
    August 01, 2009 - To play this important role in decisionmaking, CERs must address significant questions that are relevant … This approach helps ensure that a review will address important questions that decisionmakers need answered … To address these issues, AHRQ established five workgroups made up of EPC investigators, AHRQ staff, … all relevant intended effects; may not address all relevant unintended effects; or have few or only … Depending on the question, any of these types of studies might provide the best evidence to address
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
    September 01, 2014 - The adverse events and harms reported by any studies included to address any of the other questions were … used to address questions about harms and adverse events. … Only high-quality systematic reviews were included to address Key Questions 1a and 2a. … To address this question, we abstracted data about harms reported by the included studies to address … A systematic review published in 2005 (thus not included to address the Key Questions) concluded that
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
    April 01, 2012 - The appropriate study to address the key questions would include studies of screened versus non screened … The appropriate study to address Key Question 2 would include studies of screened versus non screened … In addition, the authors should address the limitations of this current report and how their approach … The appropriate study to address the key questions for the screening review would include studies of … We did not identify any new studies to address Key Question 5 and identified 72 additional studies
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - A draft version of their handbook, which is at present incomplete, has begun to address these challenges
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_disposition-comments.pdf
    April 25, 2013 - well defined, but the key questions should be revised as follows: KQ1 is problematic in that it addresses … The former group should be used to address proper approach to diagnosis. … The latter should be used to address screening. … Public Reviewer - ACCP 2 Do KQs address clinically important issues? … Yes, the key questions address clinically important issues.
  13. effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
    January 01, 2012 - treatments, screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … The system is intended to identify interventions that purport to address an unmet need and are up to … complementary and unlikely to have as significant an impact on autism treatment as interventions that address … the efficacy of these treatments is unpredictable and varies widely, and when they do work, they address
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/advanced-care-decision-aids_technical-brief.pdf
    July 01, 2014 - ACP decision aids can also address questions regarding where patients wish to die, such as in their … Many of the general tools targeted at healthy older adults address multiple ACP topics (mode, four topics … National Hospice and Palliative Care Organization / End-of- Life Decisions X X X This booklet addresses … Yet, no Federal or State mandates address the content or structure of ACP discussions; every State … Caring Connections General planning before a medical event or terminal illness This booklet addresses
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_disposition-comments.pdf
    February 13, 2012 - Yes, this is a complex issue to address. … the inclusion and exclusion criteria for patient populations are not clear and specifically fail to address … addition, little information was reported about different patient subgroups, making it difficult to address … Affiliation Section Comment Response Peer Reviewer #2 General The key clinical question this review thus addresses … The changes to the text clarifying the patient population made in response to points above also address
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_executive.pdf
    March 01, 2012 - CCP Test for pSLE in Children With MSK Pain No studies provided information to address this question … Clinical Impacts of ANA, RF, and CCP Tests No studies provided information to address this question. … Fifteen case-control studies did not specifically address the test performance of RF among children … The 12 case-control studies looking at other test-disease combinations did not specifically address … The STARD checklist includes 25 items that address the level of detail that should be specified within
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-treatment-future_research.pdf
    September 01, 2012 - In general, the evidence was low-to-moderate or insufficient to address the Key Questions adequately … Finally, we evaluated potential study designs to address each of the highest-ranked research questions … After title and abstract review, we identified 15 studies that could potentially address one or more … It is clear that more than one study design may be appropriate to address a given research question. … After title and abstract review, we identified 15 studies that could potentially address one or more
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/stem-cell-children_research-protocol.pdf
    November 01, 2010 - To achieve this, we will address six key questions (see “The Key Questions,” following). II. … EPC Methods Guide, based on a system developed by the GRADE Working Group.7 This system explicitly addresses
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
    June 16, 2010 - This update will not address epoetin delta [Dynepo]. … This update will also not address the third- generation molecule, Continuous Erythropoietin Receptor … Updating a literature-based systematic review and meta-analysis would not provide data to address this … Eligible studies will include those suitable to address questions not informed by trials. … of the overall body of evidence developed by the GRADE Working Group.57 The GRADE system explicitly addresses
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_research-protocol.pdf
    December 23, 2014 - The decisional dilemmas that this review aims to address are whether and under what circumstances it … The review will also address whether adjuvant treatment has been shown to lead to improved outcomes … While several current reviews address the use of beta- blockers (e.g., propranolol) and corticosteroids … Searches for comparative effectiveness include terms to address harms (Appendix B, Tables 4-6). … We will not rate the quality of studies that address the contextual questions. E.

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