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21. Aspirin for the Prevention of Cancer Incidence and Mortality: Systematic Evidence Reviews for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/Njxn2r3qtWKdBf2_VhS2Aw
    April 01, 2016 - CRC cases, 240 CRC deaths k = 2; n = 7588; 216 incident CRC cases Primary CVD prevention studies AAA … , BMD, ETDRS, JPAD, POPADAD, TPT�� BMD, TPT�� AAA, BMD, JPAD, TPT��, POPADAD AAA, BMD, ETDRS, HOT, … et al, 1988 (BMD) (54) Belch et al, 2008 (POPADAD) (55) MRC, 1998 (TPT) (52) Fowkes et al, 2010 (AAA … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … (0.74–0.99) AAA, BMD*, POPADAD (SAPAT) Primary ≥1 y ≤325 mg/d 5 67 787 0.98 (0.93–1.04) AAA, HOT, POPADAD

22. Bleeding Risks With Aspirin Use for Primary Prevention in Adults: A Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/j69Hq5ALvzg74e-ngkzSep
    April 01, 2016 - Year (Reference) HOT, 1998 (24) JPAD, 2008 (25) PHS, 1989 (26) BMD, 1988 (27) TPT, 1998 (29) AAA … al (main analysis), 2015 (5)* Any 7 94 307 1.59 (1.32–1.91); I2 = 22.2% HOT, JPAD, PHS, BMD, TPT, AAA … , WHS ≤100 mg 5 67 097 1.58 (1.29–1.95); I2 = 28.6% HOT, JPAD, TPT, AAA, WHS ATT Collaboration, 2009 … ), 2015 (5) Any 10 114 540 1.34 (1.07–1.70); I2 = 0% PPP, TPT, HOT, JPAD, PHS, JPPP, BMD, POPADAD, AAA … , and WHS ≤100 mg 8 87 330 1.30 (1.00–1.68); I2 = 0% PPP, TPT, HOT, JPAD, JPPP, POPADAD, AAA, and WHS

23. Archived: Evidence Summary: Bleeding Risks With Aspirin Use: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - , WHS ≤100 m 5 67,097 1.58 (1.29–1.95); I 2 = 28.6% HOT, JPAD, TPT, AAA, WHS ATT … , 2015 11 Any 9 113,264 1.33 (1.03–1.71); I 2 = 0% PPP, HOT, JPAD, JPPP, PHS, BMD, TPT, AAA … , WHS ≤100 mg 7 86,054 1.27 (0.96–1.68); I 2 = 0% PPP, HOT, JPAD, JPPP, TPT, AAA, WHS … WHS ≤100 mg 8 87,330 1.30 (1.00–1.68); I 2 = 0% PPP, TPT, HOT, JPAD, JPPP, POPADAD, AAA … ‡ Included primary CVD prevention trials: TPT, HOT, PPP, POPADAD, AAA, and JPAD.

24. Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Evidence Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/wBcZfBcVp8N3-cyT3Peysv
    April 01, 2016 - JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … 1710 41/638 25/1272 38/1675 244/19 942 Events, n/N 0.5 1 2 Favors Intervention Favors Control AAA … JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … n/N 0.25 0.5 1 2 4 Favors Intervention Favors Control 0.5 1 2 Favors Intervention Favors Control AAA

25. 10th Annual Report to Congress on High-Priority Evidence Gaps (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/10th-USPSTF-Annual-Report-to-Congress.pdf
    November 01, 2020 - Abdominal Aortic Aneurysm The USPSTF recommends one-time screening for abdominal aortic aneurysm (AAA … (Grade C) The USPSTF recommends against routine screening for AAA with ultrasonography in women who … have never smoked and have no family history of AAA. … the current evidence is insufficient to assess the balance of benefits and harms of screening for AAA … with ultrasonography in women ages 65 to 75 years who have ever smoked or have a family history of AAA

26. Archived: Evidence Summary: Aspirin Use to Prevent Cardiovascular Events: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cardiovascular/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … asymptomatic PAD (ABI ≤0.99) aged ≥40 y 100 mg/d, tablet, not enteric-coated 6.7 ǁ 3.09 AAA … hypertension, dyslipidemia, or diabetes 100 mg/d, tablet, enteric-coated 5.02 ǁ 0.57 AAA

27. A and B Recommendations | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations
    June 01, 2025 - years who have ever smoked The USPSTF recommends 1-time screening for abdominal aortic aneurysm (AAA

28. Evidence Summary: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary--html/cardiovascular-disease-screening-using-nontraditional-risk-assessment
    July 10, 2018 - to practice KQ4: ABI-Guided Treatment Benefit CVD events 2 studies, n = 4626 (2 RCT) AAA … KQ5: ABI-Guided Aspirin Treatment Harms Major bleeding 2 studies, n = 4626 (2 RCT) AAA … significant difference in bleeding events between low-dose aspirin (100 mg daily) and placebo However, AAA … of the larger body of evidence on adverse events from high-intensity statins Abbreviations: AAA

29. Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/_nVeFxDCT9L-_cnDf_V3fK
    July 17, 2018 - applicable to clinical practice KQ4: ABI-Guided Treatment Benefit CVD events 2 studies, n = 4626 (2 RCT) AAA … with JUPITER KQ5: ABI-Guided Aspirin Treatment Harms Major bleeding 2 studies, n = 4626 (2 RCT) AAA … significant difference in bleeding events between low-dose aspirin (100 mg daily) and placebo However, AAA … context of the larger body of evidence on adverse events from high-intensity statins Abbreviations: AAA

30. High-Priority Evidence Gaps for Clinical Preventive Services Fourth Annual Report to Congress (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annlrpt2014%20(6).pdf
    November 01, 2014 - Topic Recommendation The USPSTF recommends one-time screening for abdominal aortic aneurysm (AAA … (Grade B) The USPSTF recommends that clinicians selectively offer screening for AAA in men ages 65 … the current evidence is insufficient to assess the balance of benefits and harms of screening for AAA … (I Statement) The USPSTF recommends against routine screening for AAA in women who have never smoked

31. High-Priority Evidence Gaps for Clinical Preventive Services Fourth Annual Report to Congress (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/annlrpt2014%20(9).pdf
    November 01, 2014 - Topic Recommendation The USPSTF recommends one-time screening for abdominal aortic aneurysm (AAA … (Grade B) The USPSTF recommends that clinicians selectively offer screening for AAA in men ages 65 … the current evidence is insufficient to assess the balance of benefits and harms of screening for AAA … (I Statement) The USPSTF recommends against routine screening for AAA in women who have never smoked