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21. Evidence Summary: Abdominal Aortic Aneurysm: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/abdominal-aortic-aneurysm-screening
    December 10, 2019 - Main Outcomes and Measures: AAA and all-cause mortality; AAA rupture; treatment complications. … , the effects of rescreening for AAA on health outcomes or AAA incidence (KQ2), and the effectiveness … When assessing the benefits of repeated AAA screening and the harms of screening for AAA, RCTs and large … All trials defined AAA as an aortic diameter of 3.0 cm or greater, and AAA prevalence varied from 4% … What are the effects of rescreening for AAA on health outcomes or AAA incidence in a previously screened

22. U.S. Preventive Services Task Force Issues Draft Recommendation Statement on Screening for Abdominal Aortic Aneurysm (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/abdomanartbulletin.pdf
    February 24, 2014 - statement and published its final evidence report on screening adults for abdominal aortic aneurysm (AAA … AAA—a bulge or “ballooning” in the wall of the main artery that carries blood from the heart—often has … If untreated, a large AAA can burst or rupture without warning, and a high percentage of ruptures can … “Older male smokers are at the highest risk of developing AAA,” says Task Force co-vice chair Albert … Force found that AAA screening is very unlikely to benefit these women and may even cause harm.

23. U.S. Preventive Services Task Force Recommends Screening Some Men for Abdominal Aortic Aneurysm (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/file/supporting_documents/aaafinalrecbulletin.pdf
    June 24, 2014 - recommendation statement on screening adults age 50 years and older for abdominal aortic aneurysm (AAA … This recommendation statement applies to people who do not have any symptoms of AAA. … AAA is a serious condition that often has no symptoms. … If untreated, a large AAA can burst or rupture without warning, and a high percentage of ruptures can … “The good news is that, if you are a 65-to-75-year-old man who smokes or used to smoke, one-time AAA

24. Primary Care Screening for Abdominal Aortic Aneurysm: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/XAaYbGVD_xRoMfQ-huJkJq
    December 10, 2019 - cm) AAA treatment benefits and harms. … MAIN OUTCOMES AND MEASURES AAA and all-cause mortality; AAA rupture; treatment complications. … , the ef- fects of rescreening for AAA on health outcomes or AAA incidence (KQ2), and the effectiveness … When assessing the benefits of re- peated AAA screening and the harms of screening for AAA, RCTs and … All trials defined AAA as an aortic diameter of 3.0 cm or greater, and AAA prevalence varied from 4%

25. Evidence Summary: Aspirin Use to Prevent Cancer: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - , BMD, ETDRS, JPAD, POPADAD, TPT ǁ BMD, TPT ǁ AAA, BMD, JPAD, TPT ǁ , POPADAD AAA, BMD, ETDRS, … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … , BMD * , HOT, POPADAD, PPP Primary ≥4 y Any 4 49,641 0.98 (0.92–1.05) AAA, BMD * , … POPADAD, WHS Primary ≥4 y Daily 3 9765 0.88 (0.75–1.02) AAA, BMD * , POPADAD … ≥1 y ≤100 mg/d 5 67,787 0.98 (0.93–1.04) AAA, HOT, POPADAD, PPP, WHS Rothwell 2012

26. Archived: Evidence Summary: Aspirin Use to Prevent Cancer: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cancer/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - , BMD, ETDRS, JPAD, POPADAD, TPT ǁ BMD, TPT ǁ AAA, BMD, JPAD, TPT ǁ , POPADAD AAA, BMD, ETDRS, … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … , BMD * , HOT, POPADAD, PPP Primary ≥4 y Any 4 49,641 0.98 (0.92–1.05) AAA, BMD * , … POPADAD, WHS Primary ≥4 y Daily 3 9765 0.88 (0.75–1.02) AAA, BMD * , POPADAD … ≥1 y ≤100 mg/d 5 67,787 0.98 (0.93–1.04) AAA, HOT, POPADAD, PPP, WHS Rothwell 2012

27. Aspirin for the Prevention of Cancer Incidence and Mortality: Systematic Evidence Reviews for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/Njxn2r3qtWKdBf2_VhS2Aw
    April 01, 2016 - CRC cases, 240 CRC deaths k = 2; n = 7588; 216 incident CRC cases Primary CVD prevention studies AAA … , BMD, ETDRS, JPAD, POPADAD, TPT�� BMD, TPT�� AAA, BMD, JPAD, TPT��, POPADAD AAA, BMD, ETDRS, HOT, … et al, 1988 (BMD) (54) Belch et al, 2008 (POPADAD) (55) MRC, 1998 (TPT) (52) Fowkes et al, 2010 (AAA … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … (0.74–0.99) AAA, BMD*, POPADAD (SAPAT) Primary ≥1 y ≤325 mg/d 5 67 787 0.98 (0.93–1.04) AAA, HOT, POPADAD

28. Evidence Summary: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/peripheral-artery-disease-in-adults-screening-with-the-ankle-brachial-index
    July 10, 2018 - Mean follow-up was 8.2 years in the AAA trial, which was terminated early because of futility, and 6.7 … The AAA trial recruited men and women from the community aged 50 to 75 years (mean, 62.0 years) with … Of the participants, 55.9% and 71.5% were women in the POPADAD and AAA trials, respectively. … In AAA and POPADAD, 33% and 31% of participants, respectively, were current smokers. … Both the AAA and the POPADAD trials reported bleeding harms associated with use of 100 mg of aspirin

29. Screening for Peripheral Artery Disease Using the Ankle-Brachial Index: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/fXJESRpEwCmPh-FQobvtAY
    July 10, 2018 - Mean follow-up was 8.2 years in the AAA trial, which was terminated early because of futility, and 6.7 … The AAA trial recruited men and women from the community aged 50 to 75 years (mean, 62.0 years) with … Of the participants, 55.9% and 71.5% were women in the POPADAD and AAA trials, respectively. … In AAA and POPADAD, 33% and 31% of participants, respectively, were current smokers. … Both the AAA and the POPADAD trials reported bleed- ing harms associated with use of 100 mg of aspirin

30. Bleeding Risks With Aspirin Use for Primary Prevention in Adults: A Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/j69Hq5ALvzg74e-ngkzSep
    April 01, 2016 - Year (Reference) HOT, 1998 (24) JPAD, 2008 (25) PHS, 1989 (26) BMD, 1988 (27) TPT, 1998 (29) AAA … al (main analysis), 2015 (5)* Any 7 94 307 1.59 (1.32–1.91); I2 = 22.2% HOT, JPAD, PHS, BMD, TPT, AAA … , WHS ≤100 mg 5 67 097 1.58 (1.29–1.95); I2 = 28.6% HOT, JPAD, TPT, AAA, WHS ATT Collaboration, 2009 … ), 2015 (5) Any 10 114 540 1.34 (1.07–1.70); I2 = 0% PPP, TPT, HOT, JPAD, PHS, JPPP, BMD, POPADAD, AAA … , and WHS ≤100 mg 8 87 330 1.30 (1.00–1.68); I2 = 0% PPP, TPT, HOT, JPAD, JPPP, POPADAD, AAA, and WHS

31. Evidence Summary: Bleeding Risks With Aspirin Use: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - , WHS ≤100 m 5 67,097 1.58 (1.29–1.95); I 2 = 28.6% HOT, JPAD, TPT, AAA, WHS ATT … , 2015 11 Any 9 113,264 1.33 (1.03–1.71); I 2 = 0% PPP, HOT, JPAD, JPPP, PHS, BMD, TPT, AAA … , WHS ≤100 mg 7 86,054 1.27 (0.96–1.68); I 2 = 0% PPP, HOT, JPAD, JPPP, TPT, AAA, WHS … WHS ≤100 mg 8 87,330 1.30 (1.00–1.68); I 2 = 0% PPP, TPT, HOT, JPAD, JPPP, POPADAD, AAA … ‡ Included primary CVD prevention trials: TPT, HOT, PPP, POPADAD, AAA, and JPAD.

32. Archived: Evidence Summary: Bleeding Risks With Aspirin Use: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-bleeding-risks-with-aspirin-use/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - , WHS ≤100 m 5 67,097 1.58 (1.29–1.95); I 2 = 28.6% HOT, JPAD, TPT, AAA, WHS ATT … , 2015 11 Any 9 113,264 1.33 (1.03–1.71); I 2 = 0% PPP, HOT, JPAD, JPPP, PHS, BMD, TPT, AAA … , WHS ≤100 mg 7 86,054 1.27 (0.96–1.68); I 2 = 0% PPP, HOT, JPAD, JPPP, TPT, AAA, WHS … WHS ≤100 mg 8 87,330 1.30 (1.00–1.68); I 2 = 0% PPP, TPT, HOT, JPAD, JPPP, POPADAD, AAA … ‡ Included primary CVD prevention trials: TPT, HOT, PPP, POPADAD, AAA, and JPAD.

33. Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Evidence Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/wBcZfBcVp8N3-cyT3Peysv
    April 01, 2016 - JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … 1710 41/638 25/1272 38/1675 244/19 942 Events, n/N 0.5 1 2 Favors Intervention Favors Control AAA … JPPP, 2014 (39) PHS I, 1989 (30) BMD, 1988 (36) POPADAD, 2008 (31) TPT, 1998 (24) AAA … n/N 0.25 0.5 1 2 4 Favors Intervention Favors Control 0.5 1 2 Favors Intervention Favors Control AAA

34. 10th Annual Report to Congress on High-Priority Evidence Gaps (pdf file)
    www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/10th-USPSTF-Annual-Report-to-Congress.pdf
    November 01, 2020 - Abdominal Aortic Aneurysm The USPSTF recommends one-time screening for abdominal aortic aneurysm (AAA … (Grade C) The USPSTF recommends against routine screening for AAA with ultrasonography in women who … have never smoked and have no family history of AAA. … the current evidence is insufficient to assess the balance of benefits and harms of screening for AAA … with ultrasonography in women ages 65 to 75 years who have ever smoked or have a family history of AAA

35. Evidence Summary: Aspirin Use to Prevent Cardiovascular Events: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cardiovascular/aspirin-to-prevent-cardiovascular-disease-and-cancer
    April 11, 2016 - AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … asymptomatic PAD (ABI ≤0.99) aged ≥40 y 100 mg/d, tablet, not enteric-coated 6.7 ǁ 3.09 AAA … hypertension, dyslipidemia, or diabetes 100 mg/d, tablet, enteric-coated 5.02 ǁ 0.57 AAA

36. Archived: Evidence Summary: Aspirin Use to Prevent Cardiovascular Events: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-aspirin-to-prevent-cardiovascular/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
    April 11, 2016 - AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle–brachial index; BMD = British Male Doctors … asymptomatic PAD (ABI ≤0.99) aged ≥40 y 100 mg/d, tablet, not enteric-coated 6.7 ǁ 3.09 AAA … hypertension, dyslipidemia, or diabetes 100 mg/d, tablet, enteric-coated 5.02 ǁ 0.57 AAA

37. A and B Recommendations | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-a-and-b-recommendations
    April 01, 2025 - years who have ever smoked The USPSTF recommends 1-time screening for abdominal aortic aneurysm (AAA

38. A and B Recommendations | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation-topics/uspstf-and-b-recommendations
    December 01, 2021 - years who have ever smoked The USPSTF recommends 1-time screening for abdominal aortic aneurysm (AAA

39. Evidence Summary: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary--html/cardiovascular-disease-screening-using-nontraditional-risk-assessment
    July 10, 2018 - to practice KQ4: ABI-Guided Treatment Benefit CVD events 2 studies, n = 4626 (2 RCT) AAA … KQ5: ABI-Guided Aspirin Treatment Harms Major bleeding 2 studies, n = 4626 (2 RCT) AAA … significant difference in bleeding events between low-dose aspirin (100 mg daily) and placebo However, AAA … of the larger body of evidence on adverse events from high-intensity statins Abbreviations: AAA

40. Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/_nVeFxDCT9L-_cnDf_V3fK
    July 17, 2018 - applicable to clinical practice KQ4: ABI-Guided Treatment Benefit CVD events 2 studies, n = 4626 (2 RCT) AAA … with JUPITER KQ5: ABI-Guided Aspirin Treatment Harms Major bleeding 2 studies, n = 4626 (2 RCT) AAA … significant difference in bleeding events between low-dose aspirin (100 mg daily) and placebo However, AAA … context of the larger body of evidence on adverse events from high-intensity statins Abbreviations: AAA