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effectivehealthcare.ahrq.gov/sites/default/files/worker-health_executive.pdf
April 01, 2016 - effectiveness to help identify
future research priorities. … can use to
inform a workshop focused on TWH.15 This review
will describe the body of evidence evaluating … Data Repository for reference and
use in future research.19
Literature Searches
Figure B (disposition … Approximately
half of the studies measured a final health outcome
(e.g., quality of life, functional … In addition, they should use methods to
address missing data (e.g., imputation of missing
data) when
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/procalcitonin_executive.pdf
October 01, 2012 - Outcome: Antibiotic use (duration of antibiotic therapy,
prescription rate,a and total antibiotic exposureb … effect on physician behavior, so the present
evidence does not address the long-term outcome of using … Research Gap 4: Does the Use of Procalcitonin
Guidance Reduce Antibiotic Resistance and Antibiotic … Effect of
procalcitonin-guided treatment on antibiotic use and outcome
in lower respiratory tract infections … Decreasing antibiotic use in
ambulatory practice: impact of a multidimensional intervention on
the
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effectivehealthcare.ahrq.gov/sites/default/files/s38.pdf
October 01, 2007 - of the outcome of interest. … Use of such a
score is akin to balancing on a propensity score or a multivariate
risk score.26
To illustrate … Based on these data, we developed a predictive model for
such baseline use including the variables shown … A first decision in study design is the choice of the
unit of randomization, and data on sharing of patients … A review of use of health care utilization
databases for epidemiologic research on therapeutics.
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effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
October 01, 2013 - If information is also collected on those who are
either not exposed or do not have the outcome
of … Reliance
on ICD-9 codes or use of a statement in the
medical record that “albuminuria decreased” will … for research use
at a later point. … For questions amenable to the use of secondary
data, observational research with existing data
can … Mackinnon A. The use and reporting of multiple
imputation in medical research - a review.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
January 01, 2016 - Data Synthesis
We used a hierarchy-of-evidence approach that focused
on the best evidence for each … In
addition to the sparseness of reporting on the outcome of
appropriate prescribing, the few studies … Evidence of a Negative Effect on Antibiotic
Prescribing
Evidence in children showed that use of the … We had
no evidence on the effect of other patient characteristics
on any outcome (i.e., nature and … Future Research Needs
Based on the gaps and weaknesses identified through the
systematic review of
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
March 01, 2012 - mechanical methods of thromboprophylaxis; and report
data on at least one prespecified outcome. … the patients, use of
concurrent standard medical therapies, and data needed to
assess intermediate … This data may be limited
because the routine use of prophylaxis may have reduced
the occurrence of … difficult to discern
based on the scant data. … The impact of the intermediate
outcome of DVT on final health outcomes such as PE
cannot be determined
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
December 17, 2013 - The underlying etiology of MS is the subject of ongoing debate within the research
community. … This medication has a lifetime use limit, so
ultimately discontinuing is not a choice. … The level of overlap depends in part on the level of sophistication a
patient brings to the decisionmaking … assessment,
incomplete outcome data, selective reporting, and other sources of bias (i.e., problems … Selective Outcome Reporting as a Source of
Bias in Reviews of Comparative
Source: www.effectivehealthcare.ahrq.gov
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-update_research-protocol.pdf
January 15, 2015 - The CER will be based on a
systematic review of the published scientific literature using established … In addition, we will search for ongoing research on routine preoperative
tests in the ClinicalTrials.gov … We will test the forms on several
studies and revise as necessary before full data extraction. … Based on
these, we will, in group discussion among the whole research team, determine the
strength … Blood pressure outcome of
angioplasty in atherosclerotic renal artery stenosis: a randomized trial.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-heart_executive.pdf
April 01, 2013 - Based on clinical and methodological expertise, a pair
of investigators was assigned to abstract data … both
of these studies involving the use of metformin. … Because only limited data on harms were reported in the
trials examined, data from non-SMI populations … -
centered outcomes research priorities for serious mental
illness,66 and prioritized comparative effectiveness … Metabolic considerations in the use of
antipsychotic medications: a review of recent evidence.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/traumatic-brain-injury-rehabilitation-future_research.pdf
January 01, 2013 - Questionnaire, overall we observed a limited use of MCIDs in available research. … Questionnaire, overall we observed a limited use of MCIDs in available
research. … priorities. … based on the potential impact of future research on that question. … One study
currently underway (NCT01565551) is testing the use of Common Data Element
recommendations
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pressure-ulcer-prevention_disposition-comments.pdf
May 08, 2013 - For
instances with research question 1 it is investigated if the use
of a risk assessment scale improves … studies--this should be a point
made in the section on future research. … ” be changed
to reflect the fact that one of the studies provided data on
hospital length of stay. … a total of five studies on the use of nutritional
supplementation in pressure ulcer prevention. … data is robust enough to replace estimates based
on HCUPS data.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_executive.pdf
September 11, 2015 - with or without explicit use
of a theory or model of behavior change. … of participants and personnel, blinding of outcome
assessment, incomplete outcome data, selective outcome … contributing to
effectiveness of behavioral programs for the key outcome
with the most data (i.e., … The assessment of high risk
was largely driven by incomplete outcome data (i.e., loss
to followup). … The assessment
of high risk was largely driven by incomplete outcome
data (i.e., loss to followup).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_disposition-comments.pdf
February 26, 2013 - on a very nice
review of the literature surrounding the use of intravascular
diagnostic techniques … There is a paucity evidence that the use of IVUS would improve
the outcome of patients after stenting … The research strategies
are clearly stated. The outcome measures are appropriate. … The FAME
trial is the only RCT that utilized a comparison
of FFR use versus no FFR use in stenting. … based on a good diagnostic
accuracy data from the use of FFR.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_disposition-comments.pdf
October 07, 2012 - does it mitigate the impact the narrowed scope has on the data abstracted. … of how the
outcome data is obtained in the studies (is the data collected via phone vs. inperson
clinical … The authors could comment
on their use of work by the TBI Common Data Elements Outcomes Workgroup led … The TBI Model Systems are a valuable source of non-proprietary
longitudinal data on what happens to … many limitations posed and the inability to use data/outcomes,
etc… to effectively assess the current
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
May 01, 2010 - In most instances, the data supporting
off-label drug use falls short of the rigor that
accompanies FDA … of the research available on the
spectrum of rFVIIa off-label use (Key Question 1),
(b) analysis of … RCTs on the other indications
were included in our survey of existing research
(Key Question 1). … the rate of poor functional outcome as
measured on the modified Rankin Scale (risk
difference: low-dose … These yielded a moderate
strength of evidence for the outcome of
thromboembolic events but a low strength
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
November 01, 2014 - evidence
tables; a second senior member of the team reviewed
all data abstractions for completeness … handling dropouts and missing data, validity
and reliability of outcome measures, and treatment fidelity … of similar
studies, or insufficiency or variation in outcome reporting),
we synthesized the data qualitatively … consider
the limitations of studies based on secondary data from
existing MTM programs that use opt-in … in new research require a process of
research prioritization in which the value of information
from
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
March 14, 2012 - Some research
protocols involve the use of domperidone (Motilium®). … at respected
research centers, and there is not a large amount of independent data to support its use … We will use a systematic approach to extract all data to minimize the risk of bias in this
process. … ASGE guideline: guideline on the use of
endoscopy in the management of constipation. … For the outcome of harms, we will not require a comparison group.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
October 01, 2012 - A second member of the team reviewed all data
abstractions against original articles for completeness … similar
studies, or insufficient or variation in outcome reporting),
we synthesized the data qualitatively … We
are not convinced that “one-off” studies are the best
possible use of research resources. … A related matter is encouraging investigators to use
established outcome measures to enhance the possibility … • Use established outcome measures to enable the
pooling of data or qualitative interpretations.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
October 12, 2016 - , in spite of a lack of apparent
effect of an intervention on the outcome. … As a matter of fact, the
"mastodontic" amount of research on fatty acids has
delivered a small mouse … articles were not reporting on
analyses of data from a previous trial or a
longer term follow-up of … articles
were not reporting on analyses of data
from a previous trial or a longer term
follow-up … We stated in the Methods that we
included any biomarker data that were
associated with an outcome of
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effectivehealthcare.ahrq.gov/sites/default/files/fecal-incontinence_disposition-comments.pdf
March 21, 2016 - We added a statement
to the Discussion under Research Gaps:
Validated outcome measures that capture … The Hull et al, study included data from 14 centers in the US
from 2002 to 2012 with a focus on long … It also provides a baseline foundation of research on
which to perform further research. … A bowel diary is a tool to collect information on
FI episodes, urgency, pad use, consistency of
fecal … We did
not select treatments on the frequency of use.