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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - ) and pre-test the form on a sample of studies. … the earliest report of the main (primary) outcome data to be the primary data
source. … When the study design changes during the process of a research program, for example
! … number of studies reporting on the appropriate
outcome. … We will assess directness of the evidence (direct or indirect) on the basis of the use of
surrogate
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/vitamin-d-calcium_disposition-comments.pdf
September 15, 2014 - The use of bold text has allowed the reader
delineate (and yet compare) the new with the older
data … -The cancer data was a secondary outcome -the data in
the cancer paper is incomplete because it lacks … On the point of its use, one suggestion is to clarify the
intended use that the NIH/ODS exercise was … On the point of its
use, one suggestion is to clarify the intended use that
the NIH/ODS exercise was … The use of 50,000 IU in the protocol given is
a treatment based on opinion, not evidence.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/maternal-child-outcomes-wic-disposition-comments.pdf
April 19, 2022 - At the conclusion of the public comment period, authors use the
commentators’ comments to revise the … of the available data … full picture of the relationship between WIC use and various health outcomes. … section would benefit from a clear,
detailed description of handling of missing data or data conversions … included missing
data, a general statement on how missing data were handled is appropriate.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-infertility_research-protocol.pdf
September 02, 2016 - online: September 2, 2016
2
to allow our team to focus on a subset of KQs, where clinical trials … Manual matching will be performed initially by a research assistant, who will rate
her confidence in … Estimate of Person-hours to Complete the Project
EPC staff routinely log the time spent working on … Impact on Systematic Review Conclusions
Study conclusions will flow from the strength of evidence … We will use the GRADE
framework for evaluating SOE, a framework that includes assessment of risk of
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
October 04, 2016 - The review will also highlight areas of controversy and identify needs
for future research on these … are available, only outcome data from the report with the
largest number of patients will be included … We will make an exception and include data
from a smaller study when it reports data on an outcome that … A rating of insufficient will be given when the evidence does not permit a conclusion for the
outcome … A refined method for the meta-analysis of controlled clinical trials with binary outcome.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypofractionated-radiation-therapy-protocol.pdf
April 17, 2024 - Data Abstraction and Data Management: We will use a structured approach to abstract data
from each eligible … data into a standardized form, followed by a second reviewer
verifying the data for accuracy and completeness … , deviations
from intended interventions, missing outcome data, measurement of the outcome, and selection … We will assign a rating of Insufficient
when the evidence does not permit a conclusion for the outcome … Precision is the degree of certainty surrounding an effect estimate concerning a given
outcome, based
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-treatments-revised-protocol.pdf
March 29, 2023 - A decision to discontinue including them will be made based on the strength of
the RCT evidence. … When the RCT evidence on a given KQ and outcome is insufficient, we will
include observational studies … , for function as a mean difference of 10 to 20 points on the ODI
or 2 to 5 points on the RDQ, and for … systematic review:
• The Strength of Evidence for a primary outcome changes levels (insufficient, … Institute of Medicine Committee on Advancing Pain Research.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2011_research.pdf
January 01, 2011 - on validity.25 We concluded that a criterion was credible when the mean score
was ≥6 on a scale of … on the quality of funded research is presently
available.127 Future research using the newly developed … A report of the
Working Group on Passive Smoking. … Severity (degree of the symptoms of the chronic disease) in a definition of the outcome. … Frequency of the symptoms of the chronic disease in a definition of the outcome.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - Data Abstraction and Data Management
The research team will create data abstraction forms and evidence … Based on clinical and methodological
expertise, a pair of researchers will be assigned to the research … use data abstracted on the population studied,
the intervention and comparator, the outcomes measured … effect of OC use on ovarian cancer will be the lack of
randomized trial data; recent experience with … currently in use, and clinical relevance and timing
of the outcome measures.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
July 26, 2012 - There is also a lack of data on the
adverse effects of the treatments that are currently used. … There is also a lack of data on the
adverse effects of the treatments that are currently used. … It is also possible that use of stone
growth as a clinical outcome to guide
treatment could lead to … This is not a limitation of this report but rather a
limitation on the available data
Thank you. … This is not a limitation of
this report but rather a limitation on the available data.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/disparities-quality-improvement_research-protocol.pdf
February 23, 2012 - Comparators:
The comparator must be either non-use of a quality improvement strategy … Research on quality improvement interventions in health care,
and more specifically, research on quality … The search strategies will use a combination of subject
headings (i.e. controlled vocabulary) and keywords … Decision rules regarding detailed use of the quality-assessment tools will be specified
a priori by … The influence of context on quality improvement success in health care: a
systematic review of the
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-children_research-protocol.pdf
December 11, 2015 - validity) of studies, we will use predefined design-specific criteria based on
guidance in the Methods … We will consider the risk of bias for each relevant outcome of a study. … Data Synthesis: If we find five or more similar studies that use a common design (all
RCTs or all cohort … of similar studies,
insufficiency or variation in outcome reporting), we will synthesize the data qualitatively … Contextual Frameworks for Research on
the Implementation of Complex System Interventions.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/quality-gap-palliative-hospice_executive.pdf
October 01, 2012 - Due to the nature of the data (narrative), we
used a consecutive two-reviewer process to abstract data … In this process, a research
assistant abstracted data directly to tables, and these
data were checked … with the intervention on this
outcome. … for palliative radiotherapy), which found a
statistically significant improvement in the use of single … Finally, the use of
different quality improvement types was limited in studies
focusing on populations
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - Unfortunately, the data available for such studies are frequently missing detailed
information on the … outcome, X is the treatment, Z is the instrument and is a measure of the effect of
X on Y. … The numerator of this estimator is the ITT estimate—i.e., the effect of the instrument on
the outcome … use of a particular treatment. … Econometrics
in outcomes research: the use of
instrumental variables.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-202-thermoplasty-comments.pdf
December 14, 2017 - strong conclusions
based on a single trial for a given
outcome. … (considering the
risk of bias of the individual studies
contributing evidence to a specific
outcome … impact on subjective outcome
measures such as quality of life. … it does
not report unique data from a clinical
trial, since it relies on data from AIR 2. … the risk of bias of
the individual studies contributing
evidence to a specific outcome),
directness
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-261-postpartum-care-executive-summary.pdf
June 01, 2023 - We extracted study data into the Systematic Review Data Repository Plus
(SRDR+). … This was largely because the studies addressed a range of aspects of
postpartum care (general postpartum … No study that reported subgroup data statistically evaluated whether the
effect of the intervention … In addition,
future research should evaluate the impact of more comprehensive or extended health
insurance … to the number of studies that reported data for the outcome and delivery strategy comparison in that
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
May 01, 2024 - Former Director of Health Services Research and
Development (Retired)
Washington, DC
David Bates … • Conclusion
o Studies which use report card data to implement a quality improvement
initiative … patient safety practices focused on the use of report cards and outcome
measurements to improve the … o The majority of the TEP encouraged use of ASC based on a small evidence base
suggesting a benefit. … TEP encouraged the use of active surveillance
culturing of multidrug-resistant organisms based on a
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
December 08, 2014 - overlapping groups of patients were available, only
outcome data based on the larger number of patients … • For quality of life (part of KQ2), this means reporting data on a previously
tested quality-of-life … the imaging methodology (e.g.,
radiotracer, timing of test), risk of bias items, and outcome data. … another risk-of-bias category for other outcomes because the risk of bias
can depend on the outcome … In order to draw a conclusion that
two modalities differ for an outcome, we will use a p value less
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
July 21, 2014 - Data Abstraction and Data Management: Two trained research team members will
independently review all … A
second member of the team will review all data abstractions for completeness and
accuracy. … validity) of studies, we will use predefined design-specific criteria based
on guidance provided by … We will consider the risk of bias for each relevant outcome of a study. … of similar studies,
insufficiency or variation in outcome reporting), we will synthesize the data qualitatively
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-reduction-asthma-evidence-summary.pdf
February 01, 2018 - Analytic framework for indoor allergen reduction in the management of asthma
Data Sources
MEDLINE®, … • Qualitative comparative analysis affirmed the general
lack of robust findings of improved outcome … and asthma
severity), infrequent reporting of validated asthma
outcome measures, poor data reporting … We also need further
research on the interaction between the effect size of
outcome measures and meaningful … Further research on
many critical questions is needed.