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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
    March 01, 2018 - Strength of evidence domains for studies comparing lacosamide with placebo in terms of quality of life … Strength of evidence domains for studies comparing 8% capsaicin patch with placebo in terms of pain … Neurology. 1998 Jun;50(6):1842-6. PMID: 9633738. 53. . … J Am Podiatr Med Assoc. 1991 Jun;81(6):288-93. doi: 10.7547/87507315-81-6-288. … Lancet. 1988 Jan 2- 9;1(8575-6):9-11. PMID: 2891940. 60.
  2. effectivehealthcare.ahrq.gov/products/migraine-emergency/research-protocol
    July 18, 2011 - of the randomized controlled trials and nonrandomized controlled trials. 20 The tool examines six domains … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … Cephalalgia 2006;26(6):684-90. PMID: 16686907. … Rev Neurol (Paris) 2005;161(6-7):658-60.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - literature, using an instrument we develop based upon the Cochrane Risk of Bias tool.11 The seven domains … outcome data, selective reporting, and other sources of bias (i.e., problems not covered by other domains … to sustained disease progression) within each comparison will be evaluated based on four required domains … an estimate).16 A fifth domain, reporting bias, will be assessed when SOE based upon the first four domains … Q Rev Biol. 2011 Dec;86(4):287-321. 6. Daumer M, Neuhaus A, Herbert J, et al.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
    July 18, 2011 - the randomized controlled trials and nonrandomized controlled trials. 20 The tool examines six domains … The overall assessment is based on the responses to individual domains. … If one or more individual domains are assessed as having a high risk of bias, the overall score will … for Effectiveness and Comparative Effectiveness Reviews. 29 We will examine the following four domains … Rev Neurol (Paris) 2005;161(6-7):658-60. 17.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hro-protocol.pdf
    January 01, 2023 - Prioritization Report for additional details.1 HROs are organizations that operate in complex, high-hazard domains … When assessing RCTs, we will use the 7 items in the Cochrane Collaboration’s tool that cover the domains … PMID: 37838378. 6. Vogus TJ, Sutcliffe KM, Weick KE. … Crit Care. 2011;15(6):314. PMID: 22188677. 8. Veazie S, Peterson K, Bourne D. … HROs are organizations that operate in complex, high-hazard domains for extended periods without serious
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
    May 18, 2011 - Time Period KQs 1–6: 2000–present. Setting KQs 1–6: All settings. … KQs 3–6: Any study design. … Effectiveness and Comparative Effectiveness Reviews. 17 The grade will be based on four major domains … Additional domains—such as dose-response association, plausible confounding, strength of association … applicability for each outcome (including harms) will be performed separately from assessments of the other domains
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pelvic-pain_disposition-comments.pdf
    January 01, 2012 - Peer reviewer #6 Methods The inclusion and exclusion criteria are justifiable. … We have added a table describing EPC definitions of these domains to the Methods section. … We have added a table describing EPC definitions of these domains to the Methods section. … completed 6 months of treatment rather than 12 months after patient completed 6 months of treatment … We have added a table describing EPC definitions of these domains to the Methods section.
  8. effectivehealthcare.ahrq.gov/products/fecal-incontinence/research-protocol
    December 01, 2014 - percent of residents with severe cognitive impairment have experienced FI. 4 Monthly FI occurs in 6 … Colorectal Dis 2012; Jun;14(6):e297-304. PMID: 22356165. Glasgow SC, Lowry AC. … Medical care 1992; Jun;30(6):473-83. PMID: 1593914. Rockwood TH, Church JM, Fleshman JW, et al. … Dis Colon Rectum 2001; Jun;44(6):799-805. PMID: 11391139. Williams A. … No Intervention poorly described 6. Is the selection of the comparison group appropriate?
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/fecal-incontinence_research-protocol.pdf
    November 30, 2014 - Moderate risk of bias will be assigned to studies that are challenged across several of the domains … Accessed 4/18/22014. 6. Norton C, Cody June D. … Accessed 6. 9. Cazemier M, Felt-Bersma RJ, Mulder CJ. … Medical care 1992; Jun;30(6):473-83. PMID: 1593914. 28. … Dis Colon Rectum 2001; Jun;44(6):799-805. PMID: 11391139. 35. Williams A.
  10. effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
    May 18, 2011 - Time Period KQs 1–6: 2000–present. Setting KQs 1–6: All settings. … KQs 3–6: Any study design. … for Effectiveness and Comparative Effectiveness Reviews . 17 The grade will be based on four major domains … Additional domains—such as dose-response association, plausible confounding, strength of association, … applicability for each outcome (including harms) will be performed separately from assessments of the other domains
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-centered-medical-home_executive.pdf
    July 01, 2012 - Overall costs 6. … Less than 6 months longitudinal followup. … Additional domains, to be used when appropriate, are coherence, dose-response association, impact of … These domains were considered qualitatively, and a summary rating was assigned, after discussion by … PMID: 15677789. 6. Nolte E, McKee CM.
  12. effectivehealthcare.ahrq.gov/products/multiple-sclerosis/research-protocol
    December 17, 2013 - literature, using an instrument we develop based upon the Cochrane Risk of Bias tool. 11 The seven domains … incomplete outcome data, selective reporting, and other sources of bias (i.e., problems not covered by other domains … time to sustained disease progression) within each comparison will be evaluated based on four required domains … estimate). 16 A fifth domain, reporting bias, will be assessed when SOE based upon the first four domains … - interrupt$.mp. 7 - stop$.mp. 8 - 2 or 3 or 4 or 5 or 6 or 7 9 - 1 and 8 KQ1.
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gestational-diabetes-screening-diagnosis_research-protocol.pdf
    December 16, 2011 - In addition, risk of glucose intolerance and obesity in childhood is associated with GDM. 6 Much … The overall assessment is based on the responses to individual domains. … Diabetes Care 2010;33:964–8. 6. Dodd J, Crowther C, Antoniou G, et al. … Obstet Gynecol 2004;103(6):1229–34. 8. … (gestation$ adj2 (diabet$ or DM or glucose intoleran$ or insulin resistan$)).mp. 6.
  14. effectivehealthcare.ahrq.gov/products/management-infantile-epilepsy/research-protocol
    February 03, 2021 - The rating will be based on considering all of the domains listed below. … March 7, 2021 Criteria for Study Inclusion and Exclusion, Study Design Criterion #6 Allow outcome … topiramate OR valproate OR  'valproate semisodium' OR 'valproic acid' OR vigabatrin OR zonisamide 6 … Pharmacology) #5 AND #12 AND #13 15 Combine sets (KQ2 Diet, Surgery, Brain Stimuation) (#6 … (KQ3 Harms) #9 AND #12 AND #13 17 Combine sets (CQ1 Parental Preferences) ((#5 OR #6
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
    June 01, 2016 - The expected clearance rate for placebo or observation was 6 percent (95% BCI: 1% to 11%). … steroids more effective Clearance rate: Steroids 43% (95% BCI, 21% to 66%) Observation/placebo 6% … steroids more effective Clearance rate: Steroids 58% (95% BCI, 22% to 93%) Observation/placebo 6% … *The overall evidence grade was assessed based on the ratings for the following domains: study limitations … Other domains that were considered, as appropriate, included dose-response association, plausible confounding
  16. effectivehealthcare.ahrq.gov/products/dementia-agitation-aggression/research-protocol
    November 13, 2014 - The seven domains included in this tool include sequence generation, allocation concealment, blinding … International Journal of Geriatric Psychiatry. 2006 Oct;21(10):972-6. PMID 16955429. … Current Treatment Options in Neurology. 2013 Dec;15(6):765-85. PMID 24136714. Volicer L. … Journal of Clinical Psychiatry. 2008 Jun;69(6):889-98. PMID 18494535. A. P. A. … The Journal of head trauma rehabilitation. 1999;14(1):91-6. Rosen J, Burgio L, Kollar M, et al.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0376-140408.pdf
    November 06, 2013 - Intervention(s):  Psychiatric hospitalization: ultra-short (1 to 4 days), short (5 to 6), longer ( … depression, is a long-term illness involving substantial functional impairment over multiple symptom domains
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth-2010_research-protocol.pdf
    January 01, 2010 - Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: May 6, … For RCTs, the fundamental domains will include: adequate sequence generation, allocation concealment … Effectiveness and Comparative Effectiveness Reviews, 10 which emphasizes the following four major domains … comparison of interest will be given an overall evidence grade based on the ratings for the individual domains … Accessed February 4, 2011. 6. Clark SL, Belfort MA, Hankins GD, et al.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-268-racial-disparities-health-healthcare-executive-summary.pdf
    December 01, 2023 - disparities) and thereby contribute to or exacerbate unequal health outcomes (health disparities).4-6 … Using this tool, ROB ratings on each of seven domains are combined to generate an overall rating of … In six studies, ROB ratings for individual domains of bias changed because of the equity-based signaling … Lancet. 2020;396(10257):1125-8. doi: 10.1016/s0140-6736(20)32076-6. PMID: 33038972. 3. … PMID: 31649194. 6. Amutah C, Greenidge K, Mante A, et al.
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/effect-protein-intake-protocol.pdf
    May 01, 2023 - Bias tool 2.033 as low risk, some concerns (moderate risk), or high risk for each of the following domains … ROBINS-I) tool34 as low, moderate, serious, critical, or no information for each of the following domains … ROBINS-E) tool35 as low, moderate, serious, critical, or no information for each of the following domains … strength of evidence for outcomes within each comparison will be evaluated based on five required domains … Dec 2009;90(6):1509-16. doi:10.3945/ajcn.2009.27601 16.

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